Targeting the Secretin Receptor in Macrophages Attenuates Silica-Induced Pulmonary Fibrosis

Yaqian Li; Tian Li; Fuyu Jin; Shupeng Liu; Dingjie Xu; Zhongqiu Wei; Xuemin Gao; Wenchen Cai; Na Mao; Fang Yang; Haibo Zhang; Yiwei Shi; Hong Xu

doi:10.1111/cpr.70131

Cell Proliferation ›› 2025, Vol. 58 ›› Issue (12) :e70131 DOI: 10.1111/cpr.70131

LETTER TO THE EDITOR

Targeting the Secretin Receptor in Macrophages Attenuates Silica-Induced Pulmonary Fibrosis

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¹. College of TCM, North China University of Science and Technology, Tangshan, China

². College of Nursing, North China University of Science and Technology, Tangshan, China

³. School of Public Health, North China University of Science and Technology, Tangshan, China

⁴. Basic Medicine College, North China University of Science and Technology, Tangshan, China

⁵. Department of Anesthesiology and Pain Medicine, Department of Physiology, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada

⁶. The Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada

⁷. NHC Key Laboratory of Pneumoconiosis, Shanxi Key Laboratory of Respiratory Diseases, Department of Pulmonary and Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, China

⁸. Health Science Center, Hebei Key Laboratory of Integrated Utilization of Saline Alkali Land in Medical Engineering, Key Laboratory for Quality of Salt Alkali Resistant TCM of Hebei Administration of TCM, North China University of Science and Technology, Tangshan, China

hzhaibozhang@gmail.com

shiyw@sxmu.edu.cn

xuhong@ncst.edu.cn

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Yaqian Li, Tian Li, Fuyu Jin, Shupeng Liu, Dingjie Xu, Zhongqiu Wei, Xuemin Gao, Wenchen Cai, Na Mao, Fang Yang, Haibo Zhang, Yiwei Shi, Hong Xu. Targeting the Secretin Receptor in Macrophages Attenuates Silica-Induced Pulmonary Fibrosis. Cell Proliferation, 2025, 58(12): e70131 DOI:10.1111/cpr.70131

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References

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[1]	A. Churg and N. L. Muller, “Update on Silicosis,” Surgical Pathology Clinics 17, no. 2 (2024): 193–202.

[2]	A. C. Cena and L. G. Cena, “Silicosis: No Longer Exclusively a Chronic Disease,” Jaapa 37, no. 9 (2024): 14–20.

[3]	J. Feary, A. Devaraj, M. Burton, et al., “Artificial Stone Silicosis: A UK Case Series,” Thorax 79, no. 10 (2024): 979–981.

[4]	T. Li, X. Yang, H. Xu, and H. Liu, “Early Identification, Accurate Diagnosis, and Treatment of Silicosis,” Canadian Respiratory Journal 2022 (2022): 3769134–3769136.

[5]	H. Yuan, Y. You, Y. He, et al., “Crystalline Silica-Induced Proinflammatory Interstitial Macrophage Recruitment Through Notch3 Signaling Promotes the Pathogenesis of Silicosis,” Environmental Science & Technology 57, no. 39 (2023): 14502–14514.

[6]	X. Zhou, C. Zhang, S. Yang, et al., “Macrophage-Derived MMP12 Promotes Fibrosis Through Sustained Damage to Endothelial Cells,” Journal of Hazardous Materials 461 (2024): 132733.

[7]	S. Yang, Y. Sun, M. Long, et al., “Single-Cell Transcriptome Sequencing-Based Analysis: Probing the Mechanisms of Glycoprotein NMB Regulation of Epithelial Cells Involved in Silicosis,” Particle and Fibre Toxicology 20, no. 1 (2023): 29.

[8]	W. Cai, H. Xu, B. Zhang, et al., “Differential Expression of lncRNAs During Silicosis and the Role of LOC103691771 in Myofibroblast Differentiation Induced by TGF-beta1,” Biomedicine & Pharmacotherapy 125 (2020): 109980.

[9]	S. Megas, A. Wilbrey-Clark, A. Maartens, S. A. Teichmann, and K. B. Meyer, “Spatial Transcriptomics of the Respiratory System,” Annual Review of Physiology 87, no. 1 (2025): 447–470.

[10]	H. Kang, X. Gu, S. Cao, Z. Tong, and N. Song, “Integrated Multi-Omics Analyses Reveal the Pro-Inflammatory and Pro-Fibrotic Pulmonary Macrophage Subcluster in Silicosis,” Ecotoxicology and Environmental Safety 284 (2024): 116899.

[11]	J. Wang, X. Zhang, M. Long, et al., “Macrophage-Derived GPNMB Trapped by Fibrotic Extracellular Matrix Promotes Pulmonary Fibrosis,” Communications Biology 6, no. 1 (2023): 136.

[12]	L. Yang, X. Wei, P. Sun, et al., “Deciphering the Spatial Organization of Fibrotic Microenvironment in Silica Particles-Induced Pulmonary Fibrosis,” Journal of Hazardous Materials 478 (2024): 135540.

[13]	Y. Li, F. Jin, T. Li, et al., “Minute Cellular Nodules as Early Lesions in Rats With Silica Exposure via Inhalation,” Veterinary Sciences 9, no. 6 (2022): 251.

[14]	Y. Q. Li, X. L. An, F. Y. Jin, et al., “ISRIB Inhibits the Senescence of Type II Pulmonary Epithelial Cells to Alleviate Pulmonary Fibrosis Induced by Silica in Mice,” Ecotoxicology and Environmental Safety 264 (2023): 115410.

[15]	L. Morin, V. Lecureur, and A. Lescoat, “Results From Omic Approaches in Rat or Mouse Models Exposed to Inhaled Crystalline Silica: A Systematic Review,” Particle and Fibre Toxicology 21, no. 1 (2024): 10.

[16]	B. Liu, D. Yi, Z. Yu, et al., “TMEM100, a Lung-Specific Endothelium Gene,” Arteriosclerosis, Thrombosis, and Vascular Biology 42, no. 12 (2022): 1495–1497.

[17]	J. Wang, M. Jiang, A. Xiong, et al., “Integrated Analysis of Single-Cell and Bulk RNA Sequencing Reveals Pro-Fibrotic PLA2G7(High) Macrophages in Pulmonary Fibrosis,” Pharmacological Research 182 (2022): 106286.

[18]	T. Fabre, A. M. S. Barron, S. M. Christensen, et al., “Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation,” Science Immunology 8, no. 82 (2023): eadd8945.

[19]	N. Wu, L. Baiocchi, T. Zhou, et al., “Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury,” Hepatology 72, no. 6 (2020): 2219–2227.

[20]	N. Wu, T. Zhou, G. Carpino, et al., “Prolonged Administration of a Secretin Receptor Antagonist Inhibits Biliary Senescence and Liver Fibrosis in Mdr2 −/− Mice,” Hepatology 77, no. 6 (2023): 1849–1865.