The Impact of Maternal Gut Dysbiosis on Embryo/Fetus Development

Nairui Fan , Yao Shen , Xuesong Yang , Shuxia Ma , Guang Wang

Cell Proliferation ›› 2025, Vol. 58 ›› Issue (12) : e70124

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Cell Proliferation ›› 2025, Vol. 58 ›› Issue (12) :e70124 DOI: 10.1111/cpr.70124
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The Impact of Maternal Gut Dysbiosis on Embryo/Fetus Development
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Nairui Fan, Yao Shen, Xuesong Yang, Shuxia Ma, Guang Wang. The Impact of Maternal Gut Dysbiosis on Embryo/Fetus Development. Cell Proliferation, 2025, 58(12): e70124 DOI:10.1111/cpr.70124

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References

[1]

K. Hou, Z. X. Wu, X. Y. Chen, et al., “Microbiota in Health and Diseases,” Signal Transduction and Targeted Therapy 7, no. 1 (2022): 135.

[2]

X. Qin, M. Zhang, S. Chen, Y. Tang, J. Cui, and G. Ding, “Short-Chain Fatty Acids in Fetal Development and Metabolism,” Trends in Molecular Medicine 31, no. 7 (2025): 625–639.

[3]

Y. Liu, Y. Huang, Q. He, et al., “From Heart to Gut: Exploring the Gut Microbiome in Congenital Heart Disease,” iMeta 2, no. 4 (2023): e144.

[4]

Y. Shen, C. E. Brown, X. Li, et al., “Selective Serotonin Reuptake Inhibitors Induce Cardiac Toxicity Through Dysfunction of Mitochondria and Sarcomeres,” Communications Biology 8, no. 1 (2025): 736.

[5]

H. E. Vuong, G. N. Pronovost, D. W. Williams, et al., “The Maternal Microbiome Modulates Fetal Neurodevelopment in Mice,” Nature 586, no. 7828 (2020): 281–286.

[6]

D. Long, M. Liu, H. Li, et al., “Dysbacteriosis Induces Abnormal Neurogenesis via LPS in a Pathway Requiring NF-κB/IL-6,” Pharmacological Research 167 (2021): 105543.

[7]

B. van der Hee and J. M. Wells, “Microbial Regulation of Host Physiology by Short-Chain Fatty Acids,” Trends in Microbiology 29, no. 8 (2021): 700–712.

[8]

Y. Shen, N. Fan, S. X. Ma, X. Cheng, X. Yang, and G. Wang, “Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy,” MedComm 6, no. 5 (2025): e70168.

[9]

X. Cheng, P. Z. Li, G. Wang, et al., “Microbiota-Derived Lipopolysaccharide Retards Chondrocyte Hypertrophy in the Growth Plate Through Elevating Sox9 Expression,” Journal of Cellular Physiology 234, no. 3 (2019): 2593–2605.

[10]

L. You, L. Zhu, P. Z. Li, et al., “Dysbacteriosis-Derived Lipopolysaccharide Causes Embryonic Osteopenia Through Retinoic-Acid-Regulated DLX5 Expression,” International Journal of Molecular Sciences 21, no. 7 (2020): 2518.

[11]

A. Kaisanlahti, J. Turunen, N. Byts, et al., “Maternal Microbiota Communicates With the Fetus Through Microbiota-Derived Extracellular Vesicles,” Microbiome 11, no. 1 (2023): 249.

[12]

K. Nishiyama, M. Sanefuji, M. Kurokawa, et al., “Maternal Chronic Disease and Congenital Anomalies of the Kidney and Urinary Tract in Offspring: A Japanese Cohort Study,” American Journal of Kidney Diseases 80, no. 5 (2022): 619–628.

[13]

A. Toth, S. Steinmeyer, P. Kannan, et al., “Inflammatory Blockade Prevents Injury to the Developing Pulmonary Gas Exchange Surface in Preterm Primates,” Science Translational Medicine 14, no. 638 (2022): eabl8574.

[14]

J. Zhao, K. Tang, G. Jiang, et al., “Dynamic Transcriptomic and Regulatory Networks Underpinning the Transition From Fetal Primordial Germ Cells to Spermatogonia in Mice,” Cell Proliferation 58, no. 2 (2025): e13755.

[15]

O. Koren, L. Konnikova, P. Brodin, I. U. Mysorekar, and M. C. Collado, “The Maternal Gut Microbiome in Pregnancy: Implications for the Developing Immune System,” Nature Reviews. Gastroenterology & Hepatology 21, no. 1 (2024): 35–45.

[16]

X. Qin, M. Zhang, S. Chen, Y. Tang, J. Cui, and G. Ding, “Short-Chain Fatty Acids in Fetal Development and Metabolism,” Trends in Molecular Medicine 31, no. 7 (2024): 625–639.

[17]

H. Dang, P. Feng, S. Zhang, et al., “Maternal Gut Microbiota Influence Stem Cell Function in Offspring,” Cell Stem Cell 32, no. 2 (2025): 246–262.

[18]

L. Chen, D. Wang, S. Garmaeva, et al., “The Long-Term Genetic Stability and Individual Specificity of the Human Gut Microbiome,” Cell 184, no. 9 (2021): 2302–2315.

[19]

F. Asnicar, A. M. Thomas, A. Passerini, L. Waldron, and N. Segata, “Machine Learning for Microbiologists,” Nature Reviews. Microbiology 22, no. 4 (2024): 191–205.

[20]

M. Tian, Q. Li, T. Zheng, et al., “Maternal Microbe-Specific Modulation of the Offspring Microbiome and Development During Pregnancy and Lactation,” Gut Microbes 15, no. 1 (2023): 2206505.

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2025 The Author(s). Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.

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