Decoding the Plasticity of Cancer-Associated Fibroblasts: Mechanistic Insights and Precision Targeting Strategies in Gastric Cancer Progression and Therapeutic Resistance

References

[1] L. Wang, S. Liu, K. Li, et al., “General Requirements for the Production of Extracellular Vesicles Derived From Human Stem Cells,” Cell Proliferation 57, no. 3 (2023): e13554, https://doi.org/10.1111/cpr.13554.

[2] H. Sung, J. Ferlay, R. L. Siegel, et al., “Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries,” CA: A Cancer Journal for Clinicians 71, no. 3 (2021): 209-249, https://doi.org/10.3322/caac.21660.

[3] X. Sun, X. Lin, Q. Zhang, et al., “Safety, Effectiveness and the Optimal Duration of Preoperative Imatinib in Locally Advanced Gastric Gastrointestinal Stromal Tumors: A Retrospective Cohort Study,” Cancer Medicine 13, no. 18 (2024): e70237, https://doi.org/10.1002/cam4.70237.

[4] Z. Fang, Q. Meng, J. Xu, et al., “Signaling Pathways in Cancer-Associated Fibroblasts: Recent Advances and Future Perspectives,” Cancer Communications 43, no. 1 (2022): 3-41, https://doi.org/10.1002/cac2.12392.

[5] Y. Jin, Q. Cai, L. Wang, et al., “Paracrine Activin B-NF-κB Signaling Shapes an Inflammatory Tumor Microenvironment in Gastric Cancer via Fibroblast Reprogramming,” Journal of Experimental & Clinical Cancer Research 42, no. 1 (2023): 269, https://doi.org/10.1186/s13046-023-02861-4.

[6] X. Mao, J. Xu, W. Wang, et al., “Crosstalk Between Cancer-Associated Fibroblasts and Immune Cells in the Tumor Microenvironment: New Findings and Future Perspectives,” Molecular Cancer 20 (2021): 131, https://doi.org/10.1186/s12943-021-01428-1.

[7] W. H. Hsu, K. A. LaBella, Y. Lin, et al., “Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression,” Cancer Discovery 13, no. 12 (2023): 2652-2673, https://doi.org/10.1158/2159-8290.cd-22-1467.

[8] H. Luo, X. Xia, L. B. Huang, et al., “Pan-Cancer Single-Cell Analysis Reveals the Heterogeneity and Plasticity of Cancer-Associated Fibroblasts in the Tumor Microenvironment,” Nature Communications 13, no. 1 (2022): 6619, https://doi.org/10.1038/s41467-022-34395-2.

[9] X. Li, Z. Sun, G. Peng, et al., “Single-Cell RNA Sequencing Reveals a Pro-Invasive Cancer-Associated Fibroblast Subgroup Associated With Poor Clinical Outcomes in Patients With Gastric Cancer,” Theranostics 12, no. 2 (2022): 620-638, https://doi.org/10.7150/thno.60540.

[10] X. Chen, J. Huang, J. Wu, et al., “Human Mesenchymal Stem Cells,” Cell Proliferation 55, no. 4 (2021): e13141, https://doi.org/10.1111/cpr.13141.

[11] H. Sun, X. Wang, X. Wang, M. Xu, and W. Sheng, “The Role of Cancer-Associated Fibroblasts in Tumorigenesis of Gastric Cancer,” Cell Death & Disease 13, no. 10 (2022): 1-9, https://doi.org/10.1038/s41419-022-05320-8.

[12] J. Gu, X. Li, L. Zhao, et al., “The Role of PKM2 Nuclear Translocation in the Constant Activation of the NF-κB Signaling Pathway in Cancer-Associated Fibroblasts,” Cell Death and Disease 12, no. 4 (2021): 291, https://doi.org/10.1038/s41419-021-03579-x.

[13] H. Wu, Z. Xiang, G. Huang, et al., “BGN/FAP/STAT3 Positive Feedback Loop Mediated Mutual Interaction Between Tumor Cells and Mesothelial Cells Contributes to Peritoneal Metastasis of Gastric Cancer,” International Journal of Biological Sciences 19, no. 2 (2023): 465-483, https://doi.org/10.7150/ijbs.72218.

[14] F. Kitamura, T. Semba, N. Yasuda-Yoshihara, et al., “Cancer-Associated Fibroblasts Reuse Cancer-Derived Lactate to Maintain a Fibrotic and Immunosuppressive Microenvironment in Pancreatic Cancer,” JCI Insight 8, no. 20 (2023): e163022, https://doi.org/10.1172/jci.insight.163022.

[15] L. Deng, J. Zou, Y. Su, M. Wang, and L. Zhao, “Resveratrol Inhibits TGF-β1-Induced EMT in Gastric Cancer Cells Through Hippo-YAP Signaling Pathway,” Clinical and Translational Oncology 24, no. 11 (2022): 2210-2221, https://doi.org/10.1007/s12094-022-02882-z.

[16] Y. Wang, J. Yu, T. Zhang, et al., “Human neural stem cells,” Cell Proliferation 57, no. 4 (2023): e13564, https://doi.org/10.1111/cpr.13564.

[17] Z. Zhao and Y. Zhu, “FAP, CD10, and GPR77-Labeled CAFs Cause Neoadjuvant Chemotherapy Resistance by Inducing EMT and CSC in Gastric Cancer,” BMC Cancer 23, no. 1 (2023): 507, https://doi.org/10.1186/s12885-023-11011-0.

[18] I. H. Ham, H. J. Oh, H. Jin, et al., “Targeting Interleukin-6 as a Strategy to Overcome Stroma-Induced Resistance to Chemotherapy in Gastric Cancer,” Molecular Cancer 18, no. 1 (2019): 68, https://doi.org/10.1186/s12943-019-0972-8.

[19] M. Dhainaut, S. A. Rose, G. Akturk, et al., “Spatial CRISPR Genomics Identifies Regulators of the Tumor Microenvironment,” Cell 185, no. 7 (2022): 1223-1239, https://doi.org/10.1016/j.cell.2022.02.015.

[20] D. Li, L. Xia, P. Huang, et al., “Cancer-Associated Fibroblast-Secreted IGFBP7 Promotes Gastric Cancer by Enhancing Tumor Associated Macrophage Infiltration via FGF2/FGFR1/PI3K/AKT Axis,” Cell Death Discovery 9, no. 1 (2023): 17, https://doi.org/10.1038/s41420-023-01336-x.

RIGHTS & PERMISSIONS

2025 The Author(s). Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.