Environmental Drivers of Malignant Clonal Selection in Precancerous Lesion Evolution

Abstract

Somatic mutations accumulation and subsequent malignant clonal selection are the processes that lead to cancer. The intricacy includes exposure to carcinogens as well as the ways in which these exposures interact with genetic, polygenic, or epigenetic predispositions. It is worthwhile to investigate how environmental factors influence the initial transformation of healthy cells into malignant ones, or their effects on promoting growth, invasion, immune evasion, inflammation and drug resistance of onset cancerous cells.

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2025 The Author(s). Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.