Legionella pneumophila infection reduces the mitochondrial membrane potential through Lpg2444-inhibited mitocytosis

References

[1] MaL, LiY, PengJ, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015; 25:24-38.

[2] ZhuM, ZouQ, HuangR, et al. Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells. Cell Res. 2021; 31:237-240.

[3] JiangD, JiangZ, LuD, et al. Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nat Cell Biol. 2019; 21:966-977.

[4] DenizIA, Karbanova J, WobusM, et al. Mesenchymal stromal cell-associated migrasomes: a new source of chemoattractant for cells of hematopoietic origin. Cell Commun Signal. 2023; 21:36.

[5] DongN, NiuM, HuL, YaoQ, ZhouR, Shao F. Modulation of membrane phosphoinositide dynamics by the phosphatidylinositide 4-kinase activity of the Legionella LepB effector. Nat Microbiol. 2016; 2:16236.

[6] EscollP, SongOR, VianaF, et al. Legionella pneumophila modulates mitochondrial dynamics to trigger metabolic repurposing of infected macrophages. Cell Host Microbe. 2017; 22:302-316.e307.

[7] CreedS, McKenzie M. Measurement of mitochondrial membrane potential with the fluorescent dye tetramethylrhodamine methyl ester (TMRM). Methods Mol Biol. 2019; 1928:69-76.

[8] JiaoH, JiangD, HuX, et al. Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Cell. 2021; 184:2896-2910.e2813.

RIGHTS & PERMISSIONS

2024 The Author(s). Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.