Technical specifications for ethics review of human stem cell research

Yaojin Peng; Aijin Ma; Zhenyu Xiao; Jie Hao; Ruohan Feng; Changlin Wang; Baoyang Hu; Peijun Zhai; Ka Li; Lei Wang; Jiani Cao; Peng Xiang; Yu Zhang; Jun Wei; Xiaolong Wang; Boqiang Fu; Qubo Chen; Qiang Wei; Hengjun Gao; Jianwei Lv; Xing Liu; Yonghui Ma; Tao Cheng; Xiaoru Huang; Yeyang Su; Haihong Zhang; Qi Zhou; Tongbiao Zhao

doi:10.1111/cpr.13556

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Cell Proliferation ›› 2024, Vol. 57 ›› Issue (3) : e13556. DOI: 10.1111/cpr.13556

PRACTICE INSIGHTS

Technical specifications for ethics review of human stem cell research

Yaojin Peng¹^,²^,³^,⁴^,⁵ ,
Aijin Ma⁵^,⁶ ,
Zhenyu Xiao⁵^,⁷ ,
Jie Hao¹^,²^,³^,⁵^,⁸^,⁹ ,
Ruohan Feng¹^,² ,
Changlin Wang⁵^,¹⁰ ,
Baoyang Hu¹^,²^,³^,⁴^,⁵ ,
Peijun Zhai⁵^,¹¹ ,
Ka Li⁵^,¹² ,
Lei Wang¹^,²^,³^,⁵^,⁸^,⁹ ,
Jiani Cao¹^,²^,³^,⁴^,⁵ ,
Peng Xiang⁵^,¹³ ,
Yu Zhang⁵^,¹⁴ ,
Jun Wei⁵^,¹⁴ ,
Xiaolong Wang⁵^,¹⁵ ,
Boqiang Fu⁵^,¹⁶ ,
Qubo Chen⁵^,¹⁷ ,
Qiang Wei⁵^,¹⁸ ,
Hengjun Gao¹⁹^,²⁰ ,
Jianwei Lv²¹ ,
Xing Liu²² ,
Yonghui Ma²¹ ,
Tao Cheng²³ ,
Xiaoru Huang³ ,
Yeyang Su²⁴ ,
Haihong Zhang²⁵ ,
Qi Zhou¹^,²^,³^,⁵ ,
Tongbiao Zhao¹^,²^,³^,⁴^,⁵

Author information +

¹. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

². Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China

³. University of Chinese Academy of Sciences, Beijing, China

⁴. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China

⁵. Chinese Society for Stem Cell Research, Shanghai, China

⁶. Beijing Technology and Business University, Beijing, China

⁷. School of Life Science, Beijing Institute of Technology, Beijing, China

⁸. National Stem Cell Resource Bank, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

⁹. China Stem Cell and Regeneration Collaborative Innovation Platform, Beijing, China

¹⁰. China National Institute of Standardization, Beijing, China

¹¹. China National Accreditation Service for Conformity Assessment, Beijing, China

¹². Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, China

¹³. Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, China

¹⁴. Zephyrm Biotechnologies Co., Ltd, Beijing, China

¹⁵. China National Research Institute of Food and Fermentation Industries, Beijing, China

¹⁶. National Institute of Metrology, Beijing, China

¹⁷. State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

¹⁸. National Pathogen Resource Center, Chinese Center for Disease Control and Prevention, Beijing, China

¹⁹. Tongji Hospital, School of Medicine, Tongji University, Shanghai, China

²⁰. Institute of Digestive Disease, School of Medicine, Tongji University, Shanghai, China

²¹. Xiamen University, Xiamen, China

²². Xiangya Hospital Central South University, Changsha, China

²³. State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

²⁴. Institute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou, China

²⁵. Peking University Health Science Center, Beijing, China

yaojin.peng@ioz.ac.cn

zhouqi@ioz.ac.cn

tbzhao@ioz.ac.cn

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Abstract

The rapid advancement of human stem cell research and its expansion into emerging areas has resulted in an escalation of ethical challenges associated with these studies. As a result, there has been a corresponding increase in both the volume and complexity of institutional ethics reviews, coupled with higher expectations for the quality of the review process. In response to these challenges, this standard provides a comprehensive outline of the fundamental principles, content, types, and procedures of ethics review, specifically focusing on non-clinical human stem cell research. Its purpose is to provide clear operational and procedural guidelines, as well as recommendations, for the ethics review of such studies. The document was originally published by the Chinese Society for Cell Biology on August 30, 2022. It is our hope that the publication of these guidelines will facilitate the integration of ethical considerations and evaluations in a structured manner throughout the entire process of stem cell research, ultimately fostering a healthy and orderly development of the field.

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Yaojin Peng, Aijin Ma, Zhenyu Xiao, Jie Hao, Ruohan Feng, Changlin Wang, Baoyang Hu, Peijun Zhai, Ka Li, Lei Wang, Jiani Cao, Peng Xiang, Yu Zhang, Jun Wei, Xiaolong Wang, Boqiang Fu, Qubo Chen, Qiang Wei, Hengjun Gao, Jianwei Lv, Xing Liu, Yonghui Ma, Tao Cheng, Xiaoru Huang, Yeyang Su, Haihong Zhang, Qi Zhou, Tongbiao Zhao. Technical specifications for ethics review of human stem cell research. Cell Proliferation, 2024, 57(3): e13556 https://doi.org/10.1111/cpr.13556

References

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