Silibinin meglumine ameliorates hepatic encephalopathy via inhibiting UCP2-mediated oxidative stress and mitochondrial dysfunction

Yue Li , Hong Chen , Xinyi Chen , Zhangqiu Zhou , Jieman Wang , Yuanyuan Zhang , Shengpeng Zhang , Hongliang He , Junping Kou

Chinese Journal of Natural Medicines ›› 2026, Vol. 24 ›› Issue (5) : 619 -631.

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Chinese Journal of Natural Medicines ›› 2026, Vol. 24 ›› Issue (5) :619 -631. DOI: 10.1016/S1875-5364(26)61180-6
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Silibinin meglumine ameliorates hepatic encephalopathy via inhibiting UCP2-mediated oxidative stress and mitochondrial dysfunction
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Keywords

Hepatic encephalopathy / Silibinin meglumine / Uncoupling protein 2 / Oxidative stress / Mitochondrial dysfunction / Mitophagy

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Yue Li, Hong Chen, Xinyi Chen, Zhangqiu Zhou, Jieman Wang, Yuanyuan Zhang, Shengpeng Zhang, Hongliang He, Junping Kou. Silibinin meglumine ameliorates hepatic encephalopathy via inhibiting UCP2-mediated oxidative stress and mitochondrial dysfunction. Chinese Journal of Natural Medicines, 2026, 24(5): 619-631 DOI:10.1016/S1875-5364(26)61180-6

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Funding

This work was supported by “the National Science and Technology Major Project” from the Ministry of Science and Technology of the People’s Republic of China (No. 2017ZX09301050).

Declaration of competing interests

These authors have no conflict of interest to declare.

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