Active herbal ingredients and drug delivery design for tumor therapy: a review

Abstract

Active herbal ingredients are gaining recognition for their potent anti-tumor efficacy, attributable to various mechanisms including tumor cell inhibition, immune system activation, and tumor angiogenesis inhibition. Recent studies have revealed that numerous anti-tumor herbal ingredients, such as ginsenosides, ursolic acid, oleanolic acid, and Angelica sinensis polysaccharides, can be utilized to develop smart drug carriers like liposomes, micelles, and nanoparticles. These carriers can deliver active herbal ingredients and co-deliver anti-tumor drugs to enhance drug accumulation at tumor sites, thereby improving anti-tumor efficacy. This study provides a comprehensive analysis of the mechanisms by which these active herbal ingredients-derived carriers enhance therapeutic outcomes. Additionally, it highlights the structural properties of these active herbal ingredients, demonstrating how their unique features can be strategically employed to design smart drug carriers with improved anti-tumor efficacy. The insights presented aim to serve as a reference and guide future innovations in the design and application of smart drug carriers for cancer therapy that leverage active herbal ingredients.

Keywords

Active herbal ingredients / Smart drug carriers / Anti-tumor therapy

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Funding

Natural Science Foundation Youth Project of Jiangsu Province(BK20240749)

Natural Science Foundation Youth Project of Jiangsu Province(BK20230462)

General Project of Natural Science Research of Jiangsu Higher Education Institutions of China(23KJB360010)

General Project of Natural Science Research of Jiangsu Higher Education Institutions of China(24KJB360017)

High-Level Key Discipline Construction Project of National Administration of Traditional Chinese Medicine(ZYYZDXK-2023083)