Layered double hydroxide nanozyme decorated polycaprolactone membranes as superoxide radical scavengers

Abstract

The excess amount of reactive oxygen species (ROS) is a crucial problem in health and in many industrial processes. Nanozymes of antioxidant enzyme mimicking features are promising ROS scavengers, however, their formulation is challenging. This work focuses on the development of a ROS decomposing polymer mesh by immobilization of Cu(II) containing layered double hydroxide (CMA3) nanozymes on the surface of polycaprolactone (PCL) membranes prepared by the electrospinning method. The CMA3 nanoparticles were electrosprayed on PCL meshes resulting in the formation of nanozyme ring patterns. The amount of immobilized CMA3 was proportional to the flow rate during electrospraying, while the interfacial spider web-like structure was not significantly affected by this parameter. The obtained PCL-CMA3 composite materials showed remarkable superoxide radical anion scavenging activity. Such a decoration of the PCL mesh with CMA3 provides a possible solution for antioxidant nanozyme formulation for biomedical and industrial applications combatting the overproduction of ROS molecules.

Keywords

Clay / Enzyme mimic / PCL / Antioxidant / Formulation

Declaration of Competing Interest

Mingdong Dong is an editorial board member for ChemPhyMater and was not involved in the editorial review or the decision to publish this article. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

CRediT authorship contribution statement

Adel Szerlauth: Writing - original draft, Validation, Methodology, Investigation, Data curation. Shivesh Anand: Writing - review & editing, Methodology, Formal analysis. Imre Szenti: Writing - review & editing, Methodology, Investigation. Menglin Chen: Writing - review & editing, Supervision, Conceptualization. Mingdong Dong: Writing review & editing, Validation, Funding acquisition. Zoltán Kónya: Writing - review & editing, Resources, Funding acquisition. István Szilágyi: Writing - review & editing, Supervision, Project administration, Funding acquisition, Conceptualization.

Acknowledgements

This work was supported by the National Research, Development and Innovation Office (2024-1.2.3-HU-RIZONT-2024-00035), the Hungarian Academy of Sciences (LP2022-16-2022) and the European Union's Horizon Europe research and innovation program under the Marie Skłodowska-Curie Action project ENSIGN (101086226).

Supplementary materials

Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.chphma.2025.10.001.

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