Experimental techniques for quantifying interactions of polymer-coated particles and surfaces: Insights for material design and optimization

Abstract

Polymer-coated particles and surfaces have widespread applications in various industries ranging from manufacturing to biomedicine. A better understanding of the stability mechanisms underlying these coatings can inspire the design of novel polymer structures and help tune their functions. This can be achieved by quantifying the particle-particle and particle-surface interactions. This paper reviews several common experimental techniques utilized to measure the interactions between polymer-coated particles and surfaces quantitatively. These techniques include atomic force microscopy (AFM), total internal reflection microscopy (TIRM), optical tweezers (OT), and quartz crystal microbalance with dissipation monitoring (QCM-D). The examples of each measuring technique were categorized based on the types of polymer coatings and their associated factors. Additionally, this review demonstrates experimental measurements of interactions involving biological objects. By understanding the fundamental particle-particle and particle-surface interactions, researchers can gain valuable insights to guide the design and functional optimization of polymer-based materials and systems across various applications.

Keywords

Colloidal stability / Atomic force microscope / Total internal reflection microscopy / Optical tweezers / Quartz crystal microbalance with dissipation monitoring

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

CRediT authorship contribution statement

Yinan Li: Writing - original draft, Validation, Methodology, Data curation, Conceptualization. To Ngai: Writing - review & editing, Supervision, Funding acquisition, Conceptualization.

Acknowledgements

The authors gratefully acknowledge financial support from the Hong Kong Special Administrative Region (HKSAR) Innovation and Technology Fund (ITF) and the Mainland-Hong Kong Joint Funding Scheme (MHKJFS-MHP/043/21).

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