The dawn of RAS-targeted therapy: a landmark breakthrough of daraxonrasib in pancreatic cancer

Chenchen Liu , Liang Liu

Clinical Cancer Bulletin ›› 2026, Vol. 5 ›› Issue (1) : 20

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Clinical Cancer Bulletin ›› 2026, Vol. 5 ›› Issue (1) :20 DOI: 10.1007/s44272-026-00072-4
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The dawn of RAS-targeted therapy: a landmark breakthrough of daraxonrasib in pancreatic cancer
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Chenchen Liu, Liang Liu. The dawn of RAS-targeted therapy: a landmark breakthrough of daraxonrasib in pancreatic cancer. Clinical Cancer Bulletin, 2026, 5 (1) : 20 DOI:10.1007/s44272-026-00072-4

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References

[1]

Park W, Chawla A, O’Reilly EM. Pancreatic cancer: a review. JAMA, 2021, 326(9): 851-862.

[2]

Siegel RL, Kratzer TB, Wagle NS, et al.Cancer statistics, 2026. CA Cancer J Clin, 2026, 76: e70043.

[3]

Conroy T, Desseigne F, Ychou M, et al.FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med, 2011, 364(19): 1817-1825.

[4]

Von Hoff DD, Ervin T, Arena FP, et al.Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med, 2013, 369(18): 1691-1703.

[5]

Dayyani F, Macarulla T, Johnson A, et al.Second-line treatment options for patients with metastatic pancreatic ductal adenocarcinoma: a systematic literature review. Cancer Treat Rev, 2023, 113: 102502.

[6]

Wolpin BM, Park W, Garrido-Laguna I, et al.Daraxonrasib in previously treated advanced RAS-mutated pancreatic cancer. N Engl J Med, 2026, 394(18): 1790-1802.

[7]

O’Reilly EM, Wainberg ZA, Hendifar AE, et al.Daraxonrasib or chemotherapy in previously treated metastatic pancreatic cancer. N Engl J Med, 2026, 395(4): 325-337.

[8]

Bailey P, Chang DK, Nones K, et al.Genomic analyses identify molecular subtypes of pancreatic cancer. Nature, 2016, 531(7592): 47-52.

[9]

Ardalan B, Ciner A, Baca Y, et al.Distinct molecular and clinical features of specific variants of KRAS codon 12 in pancreatic adenocarcinoma. Clin Cancer Res, 2025, 31(6): 1082-1090.

[10]

Strickler JH, Satake H, George TJ, et al.Sotorasib in KRAS p.G12C-mutated advanced pancreatic cancer. N Engl J Med, 2023, 388(1): 33-43.

[11]

Holderfield M, Lee BJ, Jiang JJ, et al.Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 2024, 629(8013): 919-926.

[12]

Jiang JJ, Jiang LY, Maldonato BJ, et al.Translational and therapeutic evaluation of RAS-GTP inhibition by RMC-6236 in RAS-driven cancers. Cancer Discov, 2024, 14(6): 994-1017.

[13]

Awad MM, Liu SW, Rybkin II, et al.Acquired resistance to KRAS G12C inhibition in cancer. N Engl J Med, 2021, 384(25): 2382-2393.

[14]

Sang B, Ye LF, Fu Z, et al.Disrupted molecular glue complex drives RAS inhibitor resistance. Cell, 2026, 189(10): 2918-33.e17.

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National Natural Science Foundation of China(82673408)

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