Guideline of precisional testing in intrahepatic cholangiocarcinoma: an international expert consensus

Xin Zhang , Jing Han , Ruoyu Shi , Bing Yu , Xuchen Zhang , Bin Li , Xia Sheng , Zengshan Li , Yining Zou , Huichuan Sun , Guoming Shi , Hanlin L. Wang , Jian Zhou , Jia Fan , Wenming Cong , Yuan Ji

Clinical Cancer Bulletin ›› 2025, Vol. 4 ›› Issue (1) : 9

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Clinical Cancer Bulletin ›› 2025, Vol. 4 ›› Issue (1) : 9 DOI: 10.1007/s44272-025-00036-0
Consensus and Guideline

Guideline of precisional testing in intrahepatic cholangiocarcinoma: an international expert consensus

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Abstract

Intrahepatic cholangiocarcinoma (ICC) is a highly heterogeneous tumor. Molecular profiling serves as the foundation for personalized treatment of ICC. Comprehensive molecular testing is needed to identify more patients that are suitable for specific targeted therapies. This consensus is based on clinical data from both domestic and international sources, tailored to the Chinese context, and focuses on key targets for ICC. We present 15 recommendations aimed at guiding the precision detection of ICC.

Keywords

Intrahepatic cholangiocarcinoma / Precision detection / Biomarkers / Personalized treatment

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Xin Zhang, Jing Han, Ruoyu Shi, Bing Yu, Xuchen Zhang, Bin Li, Xia Sheng, Zengshan Li, Yining Zou, Huichuan Sun, Guoming Shi, Hanlin L. Wang, Jian Zhou, Jia Fan, Wenming Cong, Yuan Ji. Guideline of precisional testing in intrahepatic cholangiocarcinoma: an international expert consensus. Clinical Cancer Bulletin, 2025, 4(1): 9 DOI:10.1007/s44272-025-00036-0

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Science and Technology Commission of Shanghai Municipality(22JC1403002)

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