On a continuum model for random genetic drift: a dynamic boundary condition approach

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Abstract

We propose a new continuum model for random genetic drift by employing a dynamic boundary condition approach. The model can be viewed as a regularized version of the Kimura equation and admits a continuous solution. We establish existence and uniqueness of a strong solution to the regularized system. Numerical experiments illustrate that, for sufficiently small regularization parameters, the model can capture key phenomena of the original Kimura equation, such as gene fixation and conservation of the first moment.

Keywords

genetic drift / Kimura equation / Wright–Fisher model / dynamic boundary condition / fixation probability / energetic variational approach

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