Hypoxia and metabolic adaptation drive self-organization in organoid morphogenesis and tissue regeneration

Hans I-Chen Harn

doi:10.1093/burnst/tkag038

Burns & Trauma ›› 2026, Vol. 14 ›› Issue (1) :tkag038 DOI: 10.1093/burnst/tkag038

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Hypoxia and metabolic adaptation drive self-organization in organoid morphogenesis and tissue regeneration

Hans I-Chen Harn ^*

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Hans I-Chen Harn. Hypoxia and metabolic adaptation drive self-organization in organoid morphogenesis and tissue regeneration. Burns & Trauma, 2026, 14 (1) : tkag038 DOI:10.1093/burnst/tkag038

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References

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[3]	Lei M, Schumacher LJ, Lai YC, Juan WT, Yeh CY, Wu P, et al. Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells. Proc Natl Acad Sci USA 2017; 114: E7101-10. https://doi.org/10.1073/pnas.1700475114.

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[6]	Jiang J, Liu W, Wang M, Wang D, Wu W, Zhang M, et al. Metabolic adaptation drives self-organization during skin organoid morphogenesis. Nat Commun 2026. https://doi.org/10.1038/s41467-026-71709-0.

[7]	Ito M, Yang Z, Andl T, Cui C, Kim N, Millar SE, et al. Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature 2007; 447: 316-20. https://doi.org/10.1038/nature05766.

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[9]	Harn HI, Wang SP, Lai YC, Van Handel B, Liang YC, Tsai S. Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice. Nat Commun 2021; 12: 2595. https://doi.org/10.1038/s41467-021-22822-9.

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