Altered sensorimotor neuroplasticity in subacute patients with non-severe burn injury

Grant Rowe; Mark Fear; Dale W. Edgar; Aleksandra Miljevic; Tyler Osborne; Natalie Morellini; Merrilee Needham; Ann-Maree Vallence; Fiona Wood

doi:10.1093/burnst/tkag034

Burns & Trauma ›› 2026, Vol. 14 ›› Issue (1) :tkag034 DOI: 10.1093/burnst/tkag034

Research Article

research-article

Altered sensorimotor neuroplasticity in subacute patients with non-severe burn injury

Grant Rowe ¹^,^*
, Mark Fear ²^,³
, Dale W. Edgar ²^,³^,⁴^,⁵
, Aleksandra Miljevic ²^,⁶
, Tyler Osborne ²^,⁷^,⁸
, Natalie Morellini ²^,⁵
, Merrilee Needham ²^,⁶^,⁹^,¹⁰^,¹¹
, Ann-Maree Vallence ¹^,¹²^,¹³^,^*
, Fiona Wood ²^,³^,⁵^,⁹

Author information +

¹ School of Psychology, College of Health and Education, Murdoch University , 90 South Street, Murdoch, Perth, WA, Australia

² Fiona Wood Foundation , Perth, Australia

³ Burn Injury Research Unit, The University of Western Australia , Perth, WA, Australia

⁴ Burn Injury Research Node, The Institute for Health Research, The University of Notre Dame , WA, Australia

⁵ State Adult Burn Unit, Fiona Stanley Hospital , Perth, Australia

⁶ Perron Institute for Neurological and Translational Science , Perth, WA, Australia

⁷ School of Allied Health, College of Health and Education, Murdoch University , Perth, WA, Australia

⁸ School of Medical and Health Sciences, Edith Cowan University , Perth, WA, Australia

⁹ South Metropolitan Health Service , Perth, WA, Australia

¹⁰ The University of Notre Dame , WA, Australia

¹¹ Murdoch University , Perth, WA, Australia

¹² Centre for Healthy Ageing, Health Futures Institute, Murdoch University , Perth, WA, Australia

¹³ Personalised Medicine Centre, Health Futures Institute, Murdoch University , Perth, WA, Australia

^*Ann-Maree Vallence, E-mail:ann-maree.vallence@murdoch.edu.au;

Grant Rowe, Email:grant.rowe@murdoch.edu.au.

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Abstract

Background: Burn injuries affect the central nervous system, and evidence suggests they induce changes in cortical excitability related to motor dysfunction. The current study investigated markers of neuroplasticity in the motor cortex and motor performance in the subacute period following burn injury. Methods: Thirty-four patients with a non-severe burn injury (total body surface area: 1.0 ± 2.0%; 16 females; age: 46.0 ± 14.0 years) participated in a longitudinal study with assessments ranging from ~1 to ~17 weeks post-injury. Transcranial magnetic stimulation was used to evaluate motor cortex excitability and short-and long-intracortical inhibition (SICI; LICI) before and after application of paired associative stimulation (PAS) to induce neuroplasticity. Motor performance was assessed using the Purdue Pegboard. Results: Patients showed improvements in bilateral motor performance from ~3 to ~6 weeks post-injury. PAS did not induce any change in net motor cortex excitability or SICI but increased LICI, which was greatest ~6 weeks post-injury. Adjusted modeling showed that greater PAS-induced increase in LICI was associated with better bilateral motor performance, suggesting an association between PAS-induced neuroplasticity of long-acting inhibitory circuits in the primary motor cortex and motor function following burn injury. Conclusions: The data provide a neurophysiological basis to test whether targeting inhibitory networks in the subacute period after burn injury can enhance or expedite functional recovery.

Keywords

Burn injury / Subacute / Motor performance / Neuroplasticity / Intracortical inhibition

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Grant Rowe, Mark Fear, Dale W. Edgar, Aleksandra Miljevic, Tyler Osborne, Natalie Morellini, Merrilee Needham, Ann-Maree Vallence, Fiona Wood. Altered sensorimotor neuroplasticity in subacute patients with non-severe burn injury. Burns & Trauma, 2026, 14 (1) : tkag034 DOI:10.1093/burnst/tkag034

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