Research progress of responsive electrospun dressings for precise monitoring and treatment of diabetic wounds

Abstract

Chronic diabetic wounds pose a serious health and economic burden globally. In recent years, there has been widespread attention on the research of functional and even personalized wound dressings, among which responsive smart nanofiber dressings made using electrospinning technology have shown great potential. Nanofibers have advantages such as extremely fine pore size, high porosity, and large specific surface area. By combining electrospinning technology with responsive materials and integrating electronic engineering and other manufacturing techniques, it is possible to weave smart nanofibers that can respond to specific diabetic wound environments (such as low pH, high reactive oxygen species, high glucose concentration, and overexpressed enzymes) or external conditions (such as temperature, light, and magnetic fields). This allows for the monitoring of the wound microenvironment and/or the automatic release of drugs based on changes in the wound microenvironment. Compared with ordinary dressings, this dressing can not only predict the wound state, but also respond to the specific wound (such as diabetic wound) microenvironment to promote wound healing rapidly and accurately. This article outlines the characteristics of the chronic diabetic wound microenvironment, electrospinning technology, and its application in responding to the chronic diabetic wound microenvironment.

Keywords

Chronic diabetic wounds / Microenvironment / Electrospinning technology / Responsive dressing / Monitoring

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