Indocyanine green and protoporphyrin IX fluorescence imaging of inflammation, hypoxia, and necrosis of burns

Aiping Liu; Marien Ochoa; Matthew S. Reed; Mary Junak; Joana Pashaj; Brian W. Pogue; Angela L.F. Gibson

doi:10.1093/burnst/tkaf021

Burns & Trauma ›› 2025, Vol. 13 ›› Issue (1) :tkaf021 DOI: 10.1093/burnst/tkaf021

Rapid Communications

research-article

Indocyanine green and protoporphyrin IX fluorescence imaging of inflammation, hypoxia, and necrosis of burns

Author information +

History +

PDF (478KB)

Keywords

Fluorescence imaging / Indocyanine green / Protoporphyrin IX / Burns

Cite this article

Download citation ▾

Aiping Liu, Marien Ochoa, Matthew S. Reed, Mary Junak, Joana Pashaj, Brian W. Pogue, Angela L.F. Gibson. Indocyanine green and protoporphyrin IX fluorescence imaging of inflammation, hypoxia, and necrosis of burns. Burns & Trauma, 2025, 13 (1) : tkaf021 DOI:10.1093/burnst/tkaf021

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Amerian Burn Association.Annual Burn Injury Summary Report: Analysis of Inpatient Care at Burn Centers 2018-2022 2024. [updated Available at: https://ameriburn.org/wp-content/uploads/2024/03/2023-aba-bisr-overview-w-link-to-bisr.pdf.

[2]	Singh V, Devgan L, Bhat S, Milner SM. The pathogenesis of burn wound conversion. Ann Plast Surg 2007; 59: 109-15. https://doi.org/10.1097/01.sap.0000252065.90759.e6.

[3]	Refaat A, Yap ML, Pietersz G, Walsh APG, Zeller J, Del Rosal B. et al. In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications. J Nanobiotechnol 2022; 20: 450. https://doi.org/10.1186/s12951-022-01648-7.

[4]	McUmber H, Dabek RJ, Bojovic B, Driscoll DN. Burn depth analysis using indocyanine green fluorescence: a review. J Burn Care Res 2019; 40: 513-6. https://doi.org/10.1093/jbcr/irz054.

[5]	Zajac JC, Liu A, Uselmann AJ, Lin C, Hassan SE, Faucher LD. et al. Lighting the way for necrosis excision through indocyanine green fluorescence-guided surgery. J Am Coll Surg 2022; 235: 743-55. https://doi.org/10.1097/XCS.0000000000000329.

[6]	Johansson A, Palte G, Schnell O, Tonn JC, Herms J, Stepp H.5-Aminolevulinic acid-induced protoporphyrin IX levels in tissue of human malignant brain tumors. Photochem Photobiol 2010; 86: 1373-8. https://doi.org/10.1111/j.1751-1097.2010.00799.x.

[7]	Ochoa M, Reed M.S, Pétusseau A, Pogue B. PPIX delayed fluorescence imaging as a tool for in vivo assessment of hypoxia. In: Proc SPIE Molecular-Guided Surgery: Molecules, Devices, and Applications IX. 2023; PC12361: PC123610T.

[8]	Okumura K, Yoshida K, Yoshioka K, Aki S, Yoneda N, Inoue D. et al. Photoacoustic imaging of tumour vascular permeability with indocyanine green in a mouse model. Eur Radiol Experiment 2018; 2: 5. https://doi.org/10.1186/s41747-018-0036-7.

[9]	Jones LM, Dunham D, Rennie MY, Kirman J, Lopez AJ, Keim KC. et al. In vitro detection of porphyrin-producing wound bacteria with real-time fluorescence imaging. Future Microbiol 2020; 15: 319-32. https://doi.org/10.2217/fmb-2019-0279.

[10]	Utsuki S, Oka H, Sato S, Shimizu S, Suzuki S, Tanizaki Y, et al. Histological examination of false positive tissue resection using 5-aminolevulinic acid-induced fluorescence guidance. Neurol Med Chir 2007; 47: 210-4 discussion 3-4. https://doi.org/10.2176/nmc.47.210.