Nanomedicine-based immunotherapy for tissue regeneration

Song Li , Li Lu , Yuan Xiong , Jun Xiao

Burns & Trauma ›› 2025, Vol. 13 ›› Issue (1) : tkaf015

PDF (2511KB)
Burns & Trauma ›› 2025, Vol. 13 ›› Issue (1) :tkaf015 DOI: 10.1093/burnst/tkaf015
Review
research-article
Nanomedicine-based immunotherapy for tissue regeneration
Author information +
History +
PDF (2511KB)

Abstract

Tissue regeneration is essential for repairing and restoring damaged tissues, which has significant implications for clinical outcomes. Understanding the cellular mechanisms and the role of the immune system in this process provides a basis for improved regenerative techniques. The emergence of nanomedicine has advanced this field by introducing nanoscale technology that offer precise control over therapeutic delivery and cellular interactions. By modulating immune responses, various immunotherapeutic approaches, including cytokine therapy and immune checkpoint inhibitors, can establish an optimal environment for tissue repair. This review summarizes recent findings and applications of nanomedicine-based immunotherapy in tissue regeneration. It highlights the properties and advantages of nanomedicine in immunotherapy, discusses recent progress in using nanocomposite biomaterials for tissue engineering, and addresses the challenges and future directions in this evolving field. This review aims to emphasize the promising potential of nanomedicine-based immunotherapy in tissue engineering, thereby contributing to the functional design and strategic development of next-generation nanomedicine for regenerative medicine.

Keywords

Tissue regeneration / Nanomedicine / Immunotherapy / Nanoparticles / Inflammation / Stem cells

Cite this article

Download citation ▾
Song Li, Li Lu, Yuan Xiong, Jun Xiao. Nanomedicine-based immunotherapy for tissue regeneration. Burns & Trauma, 2025, 13 (1) : tkaf015 DOI:10.1093/burnst/tkaf015

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Ayyaz A, Kumar S, Sanrgiorgi B, Ghoshal B, Gosio J, Ouladan S, et al. Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell. Nature 2019; 569: 121-5. https://doi.org/10.1038/s41586-019-1154-y.

[2]

Boyce ST, Lalley AL. Tissue engineering of skin and regenerative medicine for wound care. Burns Trauma 2018; 6: 4.

[3]

Eming SA, Wynn TA, Martin P. Inflammation and metabolism in tissue repair and regeneration. Science 2017; 356: 1026-30. https://doi.org/10.1126/science.aam7928.

[4]

Jin Y, Song Y, Lin J, Liu T, Li G, Lai B, et al. Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications. Burns Trauma 2023; 11: tkac054. https://doi.org/10.1093/burnst/tkac054.

[5]

Liu S, Yu JM, Gan YC, Qiu XZ, Gao ZC, Wang H, et al. Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications. Mil Med Res 2023; 10: 16. https://doi.org/10.1186/s40779-023-00448-w.

[6]

Tidball JG. Regulation of muscle growth and regeneration by the immune system. Nat Rev Immunol 2017; 17: 165-78. https://doi.org/10.1038/nri.2016.150.

[7]

Xiong Y, Mi BB, Lin Z, Hu YQ, Yu L, Zha KK, et al. The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity. Mil Med Res 2022; 9: 65. https://doi.org/10.1186/s40779-022-00426-8.

[8]

Yuan X, Li L, Liu H, Luo J, Zhao Y, Pan C, et al. Strategies for improving adipose-derived stem cells for tissue regeneration. Burns Trauma 2022; 10: tkac028. https://doi.org/10.1093/burnst/tkac028.

[9]

Hu C, Chu C, Liu L, Wang C, Jin S, Yang R, et al. Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing. Sci Adv 2021; 7: 7. https://doi.org/10.1126/sciadv.abf0787.

[10]

Qiao D, Cheng S, Xing Z, Zhang Q, Song S, Yan F, et al. Bio-inspired glycosylated nano-hydroxyapatites enhance endogenous bone regeneration by modulating macrophage M2 polarization. Acta Biomater 2023; 162: 135-48. https://doi.org/10.1016/j.actbio.2023.03.027.

[11]

Yu C, Ying X, Shahbazi MA, Yang L, Ma Z, Ye L, et al. A nano-conductive osteogenic hydrogel to locally promote calcium influx for electro-inspired bone defect regeneration. Biomaterials 2023; 301: 122266. https://doi.org/10.1016/j.biomaterials.2023.122266.

[12]

Mofazzal Jahromi MA, Sahandi Zangabad P, Moosavi Basri SM, Sahandi Zangabad K, Ghamarypour A, Aref AR, et al. Nanomedicine and advanced technologies for burns: preventing infection and facilitating wound healing. Adv Drug Deliv Rev 2018; 123: 33-64. https://doi.org/10.1016/j.addr.2017.08.001.

[13]

Sheng S, Jin L, Zhang Y, Sun W, Mei L, Zhu D, et al. A Twindrive precise delivery system of platelet-neutrophil hybrid membrane regulates macrophage combined with CD47 blocking for postoperative immunotherapy. ACS Nano 2024; 18: 4981-92. https://doi.org/10.1021/acsnano.3c10862.

[14]

Zhang G, Xue H, Sun D, Yang S, Tu M, Zeng R. Soft apoptotic-cell-inspired nanoparticles persistently bind to macrophage membranes and promote anti-inflammatory and pro-healing effects. Acta Biomater 2021; 131: 452-63. https://doi.org/10.1016/j.actbio.2021.07.002.

[15]

Deng D, Li X, Zhang JJ, Yin Y, Tian Y, Gan D, et al. Biotin-Avidin system-based delivery enhances the therapeutic performance of MSC-derived exosomes. ACS Nano 2023; 17: 8530-50. https://doi.org/10.1021/acsnano.3c00839.

[16]

Ma S, Chen M, Wang Y, Wang J, Hao Y, Wang X, et al. Gelatin-sodium alginate composite hydrogel doped with black phosphorus@ZnO heterojunction for cutaneous wound healing with antibacterial, immunomodulatory, and angiogenic properties. Int J Biol Macromol 2024; 274: 133456. https://doi.org/10.1016/j.ijbiomac.2024.133456.

[17]

Yang L, Zhang D, Li W, Lin H, Ding C, Liu Q, et al. Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy. Nat Commun 2023; 14: 7658. https://doi.org/10.1038/s41467-023-43067-8.

[18]

Wang W, Xiong Y, Zhao R, Li X, Jia W. A novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold with enhanced osteoporotic osseointegration through osteoimmunomodulation. J Nanobiotechnology 2022; 20: 68. https://doi.org/10.1186/s12951-022-01277-0.

[19]

Jin S, Yang R, Chu C, Hu C, Zou Q, Li Y, et al. Topological structure of electrospun membrane regulates immune response, angiogenesis and bone regeneration. Acta Biomater 2021; 129: 148-58. https://doi.org/10.1016/j.actbio.2021.05.042.

[20]

Mahon OR, Browe DC, Gonzalez-Fernandez T, Pitacco P, Whelan IT, Von Euw S, et al. Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner. Biomaterials 2020; 239: 119833. https://doi.org/10.1016/j.biomaterials.2020.119833.

[21]

Yui S, Azzolin L, Maimets M, Pedersen MT, Fordham RP, Hansen SL, et al. YAP/TAZ-dependent reprogramming of colonic epithelium links ECM Remodeling to tissue regeneration. Cell Stem Cell 2018; 22: 35-49.e7. https://doi.org/10.1016/j.stem.2017.11.001.

[22]

Hoang DM, Pham PT, Bach TQ, Ngo ATL, Nguyen QT, Phan TTK, et al. Stem cell-based therapy for human diseases. Signal Transduct Target Ther 2022; 7: 272. https://doi.org/10.1038/s41392-022-01134-4.

[23]

Xia H, Li X, Gao W, Fu X, Fang RH, Zhang L, et al. Tissue repair and regeneration with endogenous stem cells. Nat Rev Mater 2018; 3: 174-93. https://doi.org/10.1038/s41578-018-0027-6.

[24]

Wang Y, Fang J, Liu B, Shao C, Shi Y. Reciprocal regulation of mesenchymal stem cells and immune responses. Cell Stem Cell 2022; 29: 1515-30. https://doi.org/10.1016/j.stem.2022.10.001.

[25]

Murphy MP, Koepke LS, Lopez MT, Tong X, Ambrosi TH, Gulati GS, et al. Articular cartilage regeneration by activated skeletal stem cells. Nat Med 2020; 26: 1583-92. https://doi.org/10.1038/s41591-020-1013-2.

[26]

Younesi FS, Miller AE, Barker TH, Rossi FMV, Hinz B. Fibroblast and myofibroblast activation in normal tissue repair and fibrosis. Nat Rev Mol Cell Biol 2024; 25: 617-38. https://doi.org/10.1038/s41580-024-00716-0.

[27]

Talbott HE, Mascharak S, Griffin M, Wan DC, Longaker MT. Wound healing, fibroblast heterogeneity, and fibrosis. Cell Stem Cell 2022; 29: 1161-80. https://doi.org/10.1016/j.stem.2022.07.006.

[28]

Lee B, Lee SH, Shin K. Crosstalk between fibroblasts and T cells in immune networks. Front Immunol 2022; 13: 1103823. https://doi.org/10.3389/fimmu.2022.1103823.

[29]

Lucas T, Waisman A, Ranjan R, Roes J, Krieg T, Müller W, et al. Differential roles of macrophages in diverse phases of skin repair. J Immunol 2010; 184: 3964-77. https://doi.org/10.4049/jimmunol.0903356.

[30]

Butenko S, Nagalla RR, Guerrero-Juarez CF, Palomba F, David LM, Nguyen RQ, et al. Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing. Nat Commun 2024; 15: 6820. https://doi.org/10.1038/s41467-024-50072-y.

[31]

Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med 2014; 6: 265sr6. https://doi.org/10.1126/scitranslmed.3009337.

[32]

Veith AP, Henderson K, Spencer A, Sligar AD, Baker AB. Therapeutic strategies for enhancing angiogenesis in wound healing. Adv Drug Deliv Rev 2019; 146: 97-125. https://doi.org/10.1016/j.addr.2018.09.010.

[33]

Guan Y, Niu H, Liu Z, Dang Y, Shen J, Zayed M, et al. Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation. Sci Adv 2021; 7: 7. https://doi.org/10.1126/sciadv.abj0153.

[34]

Rong M, Liu D, Xu X, Li A, Bai Y, Yang G, et al. A superparamagnetic composite hydrogel scaffold as in vivo dynamic monitorable theranostic platform for osteoarthritis regeneration. Adv Mater 2024; 36: e2405641. https://doi.org/10.1002/adma.202405641.

[35]

Rodrigues M, Kosaric N, Bonham CA, Gurtner GC. Wound healing: a cellular perspective. Physiol Rev 2019; 99: 665-706. https://doi.org/10.1152/physrev.00067.2017.

[36]

Wynn TA, Vannella KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity 2016; 44: 450-62. https://doi.org/10.1016/j.immuni.2016.02.015.

[37]

Watanabe S, Alexander M, Misharin AV, Budinger GRS. The role of macrophages in the resolution of inflammation. J Clin Invest 2019; 129: 2619-28. https://doi.org/10.1172/JCI124615.

[38]

Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol 2013; 229: 176-85. https://doi.org/10.1002/path.4133.

[39]

Kumar BV, Connors TJ, Farber DL. Human T cell development, localization, and function throughout life. Immunity 2018; 48: 202-13. https://doi.org/10.1016/j.immuni.2018.01.007.

[40]

Zhu J, Paul WE. CD4 T cells: fates, functions, and faults. Blood 2008; 112: 1557-69. https://doi.org/10.1182/blood-2008-05-078154.

[41]

Gor DO, Rose NR, Greenspan NS. TH1-TH2: a procrustean paradigm. Nat Immunol 2003; 4: 503-5. https://doi.org/10.1038/ni0603-503.

[42]

Miossec P, Kolls JK. Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov 2012; 11: 763-76. https://doi.org/10.1038/nrd3794.

[43]

Chen L, Xiong Y, Hu Y, Yu C, Panayi AC, Zhou W, et al. Regulatory T cell-exosomal miR-142-3p promotes angiogenesis and osteogenesis via TGFBR1/SMAD2 inhibition to accelerate fracture repair. Chem Eng J 2022; 427: 131419. https://doi.org/10.1016/j.cej.2021.131419.

[44]

Loffredo LF, Savage TM, Ringham OR, Arpaia N. Treg-tissue cell interactions in repair and regeneration. J Exp Med 2024; 221: e20231244. https://doi.org/10.1084/jem.20231244.

[45]

Knoedler S, Knoedler L, Kauke-Navarro M, Rinkevich Y, Hundeshagen G, Harhaus L, et al. Regulatory T cells in skin regeneration and wound healing. Mil Med Res 2023; 10: 49. https://doi.org/10.1186/s40779-023-00484-6.

[46]

Reina-Campos M, Scharping NE, Goldrath AW. CD8(+) T cell metabolism in infection and cancer. Nat Rev Immunol 2021; 21: 718-38. https://doi.org/10.1038/s41577-021-00537-8.

[47]

Bernhardsson M, Dietrich-Zagonel F, Tätting L, Eliasson P, Aspenberg P. Depletion of cytotoxic (CD8+) T cells impairs implant fixation in rat cancellous bone. J Orthop Res 2019; 37: 805-11. https://doi.org/10.1002/jor.24246.

[48]

Reinke S, Geissler S, Taylor WR, Schmidt-Bleek K, Juelke K, Schwachmeyer V, et al. Terminally differentiated CD8+ T cells negatively affect bone regeneration in humans. Sci Transl Med 2013; 5: 177ra36. https://doi.org/10.1126/scitranslmed.3004754.

[49]

Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S. Functions of natural killer cells. Nat Immunol 2008; 9: 503-10. https://doi.org/10.1038/ni1582.

[50]

Thomas H, Jäger M, Mauel K, Brandau S, Lask S, Flohé SB. Interaction with mesenchymal stem cells provokes natural killer cells for enhanced IL-12/IL-18-induced interferon-gamma secretion. Mediat Inflamm 2014; 2014: 143463, 1- 11. https://doi.org/10.1155/2014/143463.

[51]

DelaRosa O, Sánchez-Correa B, Morgado S, Ramírez C, del Río B, Menta R, et al. Human adipose-derived stem cells impair natural killer cell function and exhibit low susceptibility to natural killer-mediated lysis. Stem Cells Dev 2012; 21: 1333-43. https://doi.org/10.1089/scd.2011.0139.

[52]

Julier Z, Park AJ, Briquez PS, Martino MM. Promoting tissue regeneration by modulating the immune system. Acta Biomater 2017; 53: 13-28. https://doi.org/10.1016/j.actbio.2017.01.056.

[53]

Lech M, Gröbmayr R, Weidenbusch M, Anders HJ. Tissues use resident dendritic cells and macrophages to maintain homeostasis and to regain homeostasis upon tissue injury: the immunoregulatory role of changing tissue environments. Mediat Inflamm 2012; 2012: 951390, 1-15. https://doi.org/10.1155/2012/951390.

[54]

Vinish M, Cui W, Stafford E, Bae L, Hawkins H, Cox R, et al. Dendritic cells modulate burn wound healing by enhancing early proliferation. Wound Repair Regen 2016; 24: 6-13. https://doi.org/10.1111/wrr.12388.

[55]

Chiesa S, Morbelli S, Morando S, Massollo M, Marini C, Bertoni A, et al. Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells. Proc Natl Acad Sci USA 2011; 108: 17384-9. https://doi.org/10.1073/pnas.1103650108.

[56]

Silva AM, Almeida MI, Teixeira JH, Maia AF, Calin GA, Barbosa MA, et al. Dendritic cell-derived extracellular vesicles mediate mesenchymal stem/stromal cell recruitment. Sci Rep 2017; 7: 1667. https://doi.org/10.1038/s41598-017-01809-x.

[57]

Bhatt M, Sharma M, Das B. The role of inflammatory cascade and reactive astrogliosis in glial scar formation post-spinal cord injury. Cell Mol Neurobiol 2024; 44: 78. https://doi.org/10.1007/s10571-024-01519-9.

[58]

Clayton SM, Shafikhani SH, Soulika AM. Macrophage and neutrophil dysfunction in diabetic wounds. Adv Wound Care (New Rochelle) 2024; 13: 463-84. https://doi.org/10.1089/wound.2023.0149.

[59]

Burgan J, Rahmati M, Lee M, Saiz AM. Innate immune response to bone fracture healing. Bone 2025; 190: 117327. https://doi.org/10.1016/j.bone.2024.117327.

[60]

Zhu Z, Zhou S, Li S, Gong S, Zhang Q. Neutrophil extracellular traps in wound healing. Trends Pharmacol Sci 2024; 45: 1033- 45. https://doi.org/10.1016/j.tips.2024.09.007.

[61]

Chu Z, Huang Q, Ma K, Liu X, Zhang W, Cui S, et al. Novel neutrophil extracellular trap-related mechanisms in diabetic wounds inspire a promising treatment strategy with hypoxia-challenged small extracellular vesicles. Bioact Mater 2023; 27: 257-70. https://doi.org/10.1016/j.bioactmat.2023.04.007.

[62]

van Stigt AC, Gualtiero G, Cinetto F, Dalm V, IJspeert H, Muscianisi F. The biological basis for current treatment strategies for granulomatous disease in common variable immunodeficiency. Curr Opin Allergy Clin Immunol 2024; 24: 479-87. https://doi.org/10.1097/ACI.0000000000001032.

[63]

Zerbe CS, Holland SM. Functional neutrophil disorders: chronic granulomatous disease and beyond. Immunol Rev 2024; 322: 71-80. https://doi.org/10.1111/imr.13308.

[64]

Chen Z, Wang Z, Gu Z. Bioinspired and biomimetic Nanomedicines. Acc Chem Res 2019; 52: 1255-64. https://doi.org/10.1021/acs.accounts.9b00079.

[65]

Emmerich K, White DT, Kambhampati SP, Casado GL, Fu TM, Chunawala Z, et al. Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina. Commun Biol 2023; 6: 534. https://doi.org/10.1038/s42003-023-04898-9.

[66]

Han F, Tu Z, Zhu Z, Liu D, Meng Q, Yu Q, et al. Targeting endogenous reactive oxygen species removal and regulating regenerative microenvironment at annulus fibrosus defects promote tissue repair. ACS Nano 2023; 17: 7645-61. https://doi.org/10.1021/acsnano.3c00093.

[67]

Tu C, Lu H, Zhou T, Zhang W, Deng L, Cao W, et al. Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties. Biomaterials 2022; 286: 121597. https://doi.org/10.1016/j.biomaterials.2022.121597.

[68]

Beecher G, Pinal-Fernandez I, Mammen AL, Liewluck T. Immune checkpoint inhibitor myopathy: the double-edged sword of cancer immunotherapy. Neurology 2024; 103: e210031. https://doi.org/10.1212/WNL.0000000000210031.

[69]

Ruiz Perez M, Vandenabeele P, Tougaard P. The thymus road to a T cell: migration, selection, and atrophy. Front Immunol 2024; 15: 1443910. https://doi.org/10.3389/fimmu.2024.1443910.

[70]

Weyand CM, Goronzy JJ. The immunology of rheumatoid arthritis. Nat Immunol 2021; 22: 10-8. https://doi.org/10.1038/s41590-020-00816-x.

[71]

Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, et al. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science 2017; 357: 409-13. https://doi.org/10.1126/science.aan6733.

[72]

Huang Q, Wu X, Wang Z, Chen X, Wang L, Lu Y, et al. The primordial differentiation of tumor-specific memory CD8(+) T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes. Cell 2022; 185: 4049-4066.e25. https://doi.org/10.1016/j.cell.2022.09.020.

[73]

Rosenzweig N, Dvir-Szternfeld R, Tsitsou-Kampeli A, Keren-Shaul H, Ben-Yehuda H, Weill-Raynal P, et al. PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model. Nat Commun 2019; 10: 465. https://doi.org/10.1038/s41467-019-08352-5.

[74]

Davies D, Kamdar S, Woolf R, Zlatareva I, Iannitto ML, Morton C, et al. PD-1 defines a distinct, functional, tissue-adapted state in Vdelta1(+) T cells with implications for cancer immunotherapy. Nat Cancer 2024; 5: 420-32. https://doi.org/10.1038/s43018-023-00690-0.

[75]

Aghajanian H, Kimura T, Rurik JG, Hancock AS, Leibowitz MS, Li L, et al. Targeting cardiac fibrosis with engineered T cells. Nature 2019; 573: 430-3. https://doi.org/10.1038/s41586-019-1546-z.

[76]

du Halgouet A, Darbois A, Alkobtawi M, Mestdagh M, Alphonse A, Premel V, et al. Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing. Immunity 2023; 56: 78-92.e6. https://doi.org/10.1016/j.immuni.2022.12.004.

[77]

Chuang ST, Conklin B, Stein JB, Pan G, Lee KB. Nanotechnology-enabled immunoengineering approaches to advance therapeutic applications. Nano Converg 2022; 9: 19. https://doi.org/10.1186/s40580-022-00310-0.

[78]

Dombrowski Y, O’Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, et al. Regulatory T cells promote myelin regeneration in the central nervous system. Nat Neurosci 2017; 20: 674-80. https://doi.org/10.1038/nn.4528.

[79]

Wu B, Zhao TV, Jin K, Hu Z, Abdel MP, Warrington KJ, et al. Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Nat Immunol 2021; 22: 1551-62. https://doi.org/10.1038/s41590-021-01065-2.

[80]

Lin Z, Xiong Y, Meng W, Hu Y, Chen L, Chen L, et al. Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant. Bioact Mater 2022; 13: 300-11. https://doi.org/10.1016/j.bioactmat.2021.10.042.

[81]

Chen L, Yu C, Xu W, Xiong Y, Cheng P, Lin Z, et al. Dual-targeted nanodiscs revealing the cross-talk between osteogenic differentiation of mesenchymal stem cells and macrophages. ACS Nano 2023; 17: 3153-67. https://doi.org/10.1021/acsnano.2c12440.

[82]

Xiong Y, Feng Q, Lu L, Qiu X, Knoedler S, Panayi AC, et al. Metal-organic frameworks and their composites for chronic wound healing: from bench to bedside. Adv Mater 2024; 36: e2302587. https://doi.org/10.1002/adma.202302587.

[83]

Zhao Y, Wang D, Qian T, Zhang J, Li Z, Gong Q, et al. Biomimetic nanozyme-decorated hydrogels with H(2)O(2)-activated oxygenation for modulating immune microenvironment in diabetic wound. ACS Nano 2023; 17: 16854-69. https://doi.org/10.1021/acsnano.3c03761.

[84]

Zha K, Xiong Y, Zhang W, Tan M, Hu W, Lin Z, et al. Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing. ACS Nano 2023; 17: 17199-216. https://doi.org/10.1021/acsnano.3c05075.

[85]

Gupta A, Singh S. Multimodal potentials of gold nanoparticles for bone tissue engineering and regenerative medicine: avenues and prospects. Small 2022; 18: e2201462. https://doi.org/10.1002/smll.202201462.

[86]

Li Y, Zhang M, Li S, Zhang L, Kim J, Qiu Q, et al. Selective ischemic-hemisphere targeting Ginkgolide B liposomes with improved solubility and therapeutic efficacy for cerebral ischemia-reperfusion injury. Asian J Pharm Sci 2023; 18: 100783. https://doi.org/10.1016/j.ajps.2023.100783.

[87]

Lu X, Li X, Yu J, Ding B. Nanofibrous hemostatic materials: structural design, fabrication methods, and hemostatic mechanisms. Acta Biomater 2022; 154: 49-62. https://doi.org/10.1016/j.actbio.2022.10.028.

[88]

Hu Z, Shan J, Cui Y, Cheng L, Chen XL, Wang X. Nanozyme-incorporated microneedles for the treatment of chronic wounds. Adv Healthc Mater 2024; 13:e2400101. https://doi.org/10.1002/adhm.202400101.

[89]

Kurian AG, Singh RK, Sagar V, Lee JH, Kim HW. Nanozyme-engineered hydrogels for anti-inflammation and skin regeneration. Nanomicro Lett 2024; 16: 110. https://doi.org/10.1007/s40820-024-01323-6.

[90]

Mou X, Wu Q, Zhang Z, Liu Y, Zhang J, Zhang C, et al. Nanozymes for regenerative medicine. Small Methods 2022; 6: e2200997. https://doi.org/10.1002/smtd.202200997.

[91]

Wang D, Jana D, Zhao Y. Metal-organic framework derived nanozymes in biomedicine. Acc Chem Res 2020; 53: 1389-400. https://doi.org/10.1021/acs.accounts.0c00268.

[92]

Xiong Y, Mi B, Liu G, Zhao Y. Microenvironment-sensitive nanozymes for tissue regeneration. Biomaterials 2024; 309: 122585. https://doi.org/10.1016/j.biomaterials.2024.122585.

[93]

Dong R, Ma PX, Guo B. Conductive biomaterials for muscle tissue engineering. Biomaterials 2020; 229: 119584. https://doi.org/10.1016/j.biomaterials.2019.119584.

[94]

Zare EN, Jamaledin R, Naserzadeh P, Afjeh-Dana E, Ashtari B, Hosseinzadeh M, et al. Metal-based nanostructures/PLGA nanocomposites: antimicrobial activity, cytotoxicity, and their biomedical applications. ACS Appl Mater Interfaces 2020; 12: 3279-300. https://doi.org/10.1021/acsami.9b19435.

[95]

Shang S, Zhuang K, Chen J, Zhang M, Jiang S, Li W. A bioactive composite hydrogel dressing that promotes healing of both acute and chronic diabetic skin wounds. Bioact Mater 2024; 34: 298-310. https://doi.org/10.1016/j.bioactmat.2023.12.026.

[96]

Bharadwaz A, Jayasuriya AC. Recent trends in the application of widely used natural and synthetic polymer nanocomposites in bone tissue regeneration. Mater Sci Eng C Mater Biol Appl 2020; 110: 110698. https://doi.org/10.1016/j.msec.2020.110698.

[97]

Wang Y, Wang J, Gao R, Liu X, Feng Z, Zhang C, et al. Biomimetic glycopeptide hydrogel coated PCL/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo-immunomodulation. Biomaterials 2022; 285: 121538. https://doi.org/10.1016/j.biomaterials.2022.121538.

[98]

Kim HR, Cho HB, Lee S, Park JI, Kim HJ, Park KH. Fusogenic liposomes encapsulating mitochondria as a promising delivery system for osteoarthritis therapy. Biomaterials 2023; 302: 122350. https://doi.org/10.1016/j.biomaterials.2023.122350.

[99]

Hallan SS, Amirian J, Brangule A, Bandere D. Lipid-based nano-sized cargos as a promising strategy in bone complications: a review. Nanomaterials (Basel) 2022; 12: 12. https://doi.org/10.3390/nano12071146.

[100]

Liu H, Chen J, Qiao S, Zhang W. Carbon-based nanomaterials for bone and cartilage regeneration: a review. ACS Biomater Sci Eng 2021; 7: 4718-35. https://doi.org/10.1021/acsbiomaterials.1c00759.

[101]

Maleki A, He J, Bochani S, Nosrati V, Shahbazi MA, Guo B. Multifunctional photoactive hydrogels for wound healing acceleration. ACS Nano 2021; 15: 18895-930. https://doi.org/10.1021/acsnano.1c08334.

[102]

Meng H, Zhao Y, Cai H, You D, Wang Y, Wu S, et al. Hydrogels containing chitosan-modified gold nanoparticles show significant efficacy in healing diabetic wounds infected with antibiotic-resistant bacteria. Int J Nanomedicine 2024; 19: 1539-56. https://doi.org/10.2147/IJN.S448282.

[103]

Nezhad-Mokhtari P, Akrami-Hasan-Kohal M, Ghorbani M. An injectable chitosan-based hydrogel scaffold containing gold nanoparticles for tissue engineering applications. Int J Biol Macromol 2020; 154: 198-205. https://doi.org/10.1016/j.ijbiomac.2020.03.112.

[104]

Riley RS, June CH, Langer R, Mitchell MJ. Delivery technologies for cancer immunotherapy. Nat Rev Drug Discov 2019; 18: 175-96. https://doi.org/10.1038/s41573-018-0006-z.

[105]

Xia Y, Rao L, Yao H, Wang Z, Ning P, Chen X. Engineering macrophages for cancer immunotherapy and drug delivery. Adv Mater 2020; 32: e2002054. https://doi.org/10.1002/adma.202002054.

[106]

Azharuddin M, Zhu GH, Sengupta A, Hinkula J, Slater NKH, Patra HK. Nano toolbox in immune modulation and nanovaccines. Trends Biotechnol 2022; 40: 1195-212. https://doi.org/10.1016/j.tibtech.2022.03.011.

[107]

Getts DR, Shea LD, Miller SD, King NJ. Harnessing nanoparticles for immune modulation. Trends Immunol 2015; 36: 419-27. https://doi.org/10.1016/j.it.2015.05.007.

[108]

Hosseinpour S, Walsh LJ, Xu C. Modulating osteoimmune responses by mesoporous silica nanoparticles. ACS Biomater Sci Eng 2022; 8: 4110-22. https://doi.org/10.1021/acsbiomaterials.1c00899.

[109]

Las Heras K, Garcia-Orue I, Rancan F, Igartua M, Santos-Vizcaino E, Hernandez RM. Modulating the immune system towards a functional chronic wound healing: a biomaterials and nanomedicine perspective. Adv Drug Deliv Rev 2024; 210: 115342. https://doi.org/10.1016/j.addr.2024.115342.

[110]

Li Y, Yang L, Hou Y, Zhang Z, Chen M, Wang M, et al. Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes. Bioact Mater 2022; 18: 213-27. https://doi.org/10.1016/j.bioactmat.2022.03.021.

[111]

Adu-Berchie K, Mooney DJ. Biomaterials as local niches for immunomodulation. Acc Chem Res 2020; 53: 1749-60. https://doi.org/10.1021/acs.accounts.0c00341.

[112]

Ke X, Howard GP, Tang H, Cheng B, Saung MT, Santos JL, et al. Physical and chemical profiles of nanoparticles for lymphatic targeting. Adv Drug Deliv Rev 2019; 151-152: 72-93. https://doi.org/10.1016/j.addr.2019.09.005.

[113]

Lee Y, Sugihara K, Gillilland MG 3rd, Jon S, Kamada N, Moon JJ. Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis. Nat Mater 2020; 19: 118-26. https://doi.org/10.1038/s41563-019-0462-9.

[114]

Liu Z, Chen X, Zhang Z, Zhang X, Saunders L, Zhou Y, et al. Nanofibrous spongy microspheres to distinctly release miRNA and growth factors to enrich regulatory T cells and rescue periodontal bone loss. ACS Nano 2018; 12: 9785-99. https://doi.org/10.1021/acsnano.7b08976.

[115]

Xiong Y, Lin Z, Bu P, Yu T, Endo Y, Zhou W, et al. A whole-course-repair system based on neurogenesis-angiogenesis crosstalk and macrophage reprogramming promotes diabetic wound healing. Adv Mater 2023; 35: e2212300. https://doi.org/10.1002/adma.202212300.

[116]

Conley BM, Yang L, Bhujel B, Luo J, Han I, Lee KB. Development of a nanohybrid peptide hydrogel for enhanced intervertebral disc repair and regeneration. ACS Nano 2023; 17: 3750-64. https://doi.org/10.1021/acsnano.2c11441.

[117]

Mi B, Chen L, Xiong Y, Yang Y, Panayi AC, Xue H, et al. Osteoblast/osteoclast and immune cocktail therapy of an exosome/drug delivery multifunctional hydrogel accelerates fracture repair. ACS Nano 2022; 16: 771-82. https://doi.org/10.1021/acsnano.1c08284.

[118]

Zhao Q, Wang J, Qu S, Gong Z, Duan Y, Han L, et al. Neuro-inspired biomimetic microreactor for sensory recovery and hair follicle neogenesis under skin burns. ACS Nano 2023; 17: 23115-31. https://doi.org/10.1021/acsnano.3c09107.

[119]

Zhou J, Kroll AV, Holay M, Fang RH, Zhang L. Biomimetic nanotechnology toward personalized vaccines. Adv Mater 2020; 32: e1901255. https://doi.org/10.1002/adma.201901255.

[120]

Peres C, Matos AI, Moura LIF, Acurcio RC, Carreira B, Pozzi S, et al. Preclinical models and technologies to advance nanovaccine development. Adv Drug Deliv Rev 2021; 172: 148-82. https://doi.org/10.1016/j.addr.2021.03.001.

[121]

Zhou J, Ventura CJ, Yu Y, Gao W, Fang RH, Zhang L. Biomimetic neutrophil nanotoxoids elicit potent immunity against Acinetobacter baumannii in multiple models of infection. Nano Lett 2022; 22: 7057-65. https://doi.org/10.1021/acs.nanolett.2c01948.

[122]

Zhang H, You X, Wang X, Cui L, Wang Z, Xu F, et al. Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through toll-like receptor 4 signaling. Proc Natl Acad Sci USA 2021; 118:e2005191118. https://doi.org/10.1073/pnas.2005191118.

[123]

Chen Z, Guo Z, Hu T, Huang B, Zheng Q, Du X, et al. Double-layered microneedle patch loaded with bioinspired nanovaccine for melanoma treatment and wound healing. Int J Biol Macromol 2024; 262: 129961. https://doi.org/10.1016/j.ijbiomac.2024.129961.

[124]

Irvine DJ, Dane EL. Enhancing cancer immunotherapy with nanomedicine. Nat Rev Immunol 2020; 20: 321-34. https://doi.org/10.1038/s41577-019-0269-6.

[125]

Peng S, Xiao F, Chen M, Gao H. Tumor-microenvironment-responsive nanomedicine for enhanced cancer immunotherapy. Adv Sci (Weinh) 2022; 9: e2103836. https://doi.org/10.1002/advs.202103836.

[126]

Kim J, Hong J, Lee J, Fakhraei Lahiji S, Kim YH. Recent advances in tumor microenvironment-targeted nanomedicine delivery approaches to overcome limitations of immune checkpoint blockade-based immunotherapy. J Control Release 2021; 332: 109-26. https://doi.org/10.1016/j.jconrel.2021.02.002.

[127]

Lee Y, Kamada N, Moon JJ. Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome. Adv Drug Deliv Rev 2021; 179: 114021. https://doi.org/10.1016/j.addr.2021.114021.

[128]

Yi Y, Yu M, Li W, Zhu D, Mei L, Ou M. Vaccine-like nanomedicine for cancer immunotherapy. J Control Release 2023; 355: 760-78. https://doi.org/10.1016/j.jconrel.2023.02.015.

[129]

Yang G, Xu L, Chao Y, Xu J, Sun X, Wu Y, et al. Hollow MnO(2) as a tumor-microenvironment-responsive biodegradable nanoplatform for combination therapy favoring antitumor immune responses. Nat Commun 2017; 8: 902. https://doi.org/10.1038/s41467-017-01050-0.

[130]

Ashrafizadeh M, Zarrabi A, Bigham A, Taheriazam A, Saghari Y, Mirzaei S, et al. (Nano)platforms in breast cancer therapy: drug/gene delivery, advanced nanocarriers and immunotherapy. Med Res Rev 2023; 43: 2115-76. https://doi.org/10.1002/med.21971.

[131]

Yang J, Yang K, Du S, Luo W, Wang C, Liu H, et al. Bioorthogonal reaction-mediated tumor-selective delivery of CRISPR/Cas9 system for dual-targeted cancer immunotherapy. Angew Chem Int Ed Engl 2023; 62:e202306863. https://doi.org/10.1002/anie.202306863.

PDF (2511KB)

0

Accesses

0

Citation

Detail

Sections
Recommended

/

〈 〉