MicroRNAs in septic acute kidney injury

Bo Wang; Jun Xu; Ping Fu; Liang Ma

doi:10.1093/burnst/tkad008

Burns & Trauma ›› 2023, Vol. 11 ›› Issue (1) :tkad008 DOI: 10.1093/burnst/tkad008

Review

research-article

MicroRNAs in septic acute kidney injury

Bo Wang ¹^,^†
, Jun Xu ²^,^†
, Ping Fu ¹^,^*
, Liang Ma ¹^,^*

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Abstract

Sepsis is a potentially fatal complication of burns and trauma that can cause acute kidney injury (AKI) with substantial morbidity and mortality, but this disease is poorly understood. Despite medical advances, effective therapeutic regimens for septic AKI remain uncommon. MicroRNAs (miRNAs) are endogenous non-coding RNAs that influence the translation of target messenger RNAs in a variety of biological processes. Emerging evidence has shown that miRNAs are intimately associated with septic AKI. The goal of this review was to summarize recent advances in the profound understanding of the functional role of miRNAs in septic AKI, as well as to provide new insights into miRNAs as feasible biomarkers and therapeutic targets for septic AKI.

Keywords

MicroRNAs / Sepsis / Acute kidney injury / Biomarkers / Therapeutic targets

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Bo Wang, Jun Xu, Ping Fu, Liang Ma. MicroRNAs in septic acute kidney injury. Burns & Trauma, 2023, 11 (1) : tkad008 DOI:10.1093/burnst/tkad008

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