Recent advances in nanotherapeutics for the treatment of burn wounds

Rong Huang , Jun Hu , Wei Qian , Liang Chen , Dinglin Zhang

Burns & Trauma ›› 2021, Vol. 9 ›› Issue (1) : tkab026

PDF (2255KB)
Burns & Trauma ›› 2021, Vol. 9 ›› Issue (1) :tkab026 DOI: 10.1093/burnst/tkab026
Review
research-article
Recent advances in nanotherapeutics for the treatment of burn wounds
Author information +
History +
PDF (2255KB)

Abstract

Moderate or severe burns are potentially devastating injuries that can even cause death, and many of them occur every year. Infection prevention, anti-inflammation, pain management and administration of growth factors play key roles in the treatment of burn wounds. Novel therapeutic strategies under development, such as nanotherapeutics, are promising prospects for burn wound treatment. Nanotherapeutics, including metallic and polymeric nanoformulations, have been extensively developed to manage various types of burns. Both human and animal studies have demonstrated that nanotherapeutics are biocompatible and effective in this application. Herein, we provide comprehensive knowledge of and an update on the progress of various nanoformulations for the treatment of burn wounds.

Keywords

Burn wounds / Metal and metal oxide nanotherapeutics / Polymeric nanotherapeutics / Therapeutic mechanism / Wound healing

Cite this article

Download citation ▾
Rong Huang, Jun Hu, Wei Qian, Liang Chen, Dinglin Zhang. Recent advances in nanotherapeutics for the treatment of burn wounds. Burns & Trauma, 2021, 9 (1) : tkab026 DOI:10.1093/burnst/tkab026

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Guttman-Yassky E, Zhou L, Krueger JG. The skin as an immune organ: tolerance versus effector responses and applications to food allergy and hypersensitivity reactions. J Allergy Clin Immunol. 2019; 144: 362-74.

[2]

Peck MD. Epidemiology of burns throughout the world. Part I: distribution and risk factors. Burns. 2011; 37: 1087-100.

[3]

Wang Y, Beekman J, Hew J, Jackson S, Issler-Fisher AC, Parungao R, et al. Burn injury: challenges and advances in burn wound healing, infection, pain and scarring. Adv Drug Deliv Rev. 2018; 123: 3-17.

[4]

Davies A, Spickett-Jones F, Jenkins ATA, Young AE. A systematic review of intervention studies demonstrates the need to develop a minimum set of indicators to report the presence of burn wound infection. Burns. 2020; 46: 1487-97.

[5]

Ahmadi AR, Chicco M, Huang J, Qi L, Burdick J, Williams GM, et al. Stem cells in burn wound healing: a systematic review of the literature. Burns. 2019; 45: 1014-23.

[6]

Li Y, Xia WD, Van der Merwe L, Dai WT, Lin C. Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies. Stem Cell Res Ther. 2020; 11: 322.

[7]

Wang W, Lu KJ, Yu CH, Huang QL, Du YZ. Nano-drug delivery systems in wound treatment and skin regeneration. J Nanobiotechnology. 2019; 17: 82.

[8]

Rowan MP, Cancio LC, Elster EA, Burmeister DM, Rose LF, Natesan S, et al. Burn wound healing and treatment: review and advancements. Crit Care. 2015; 19: 12. doi: 10.1186/s13054-015-0961-2.

[9]

Cancio LC.Topical antimicrobial agents for burn wound care: history and current status. Surg Infect (Larchmt). 2021; 22: 3-11.

[10]

Khalid A, Khan R, Ul-Islam M, Khan T, Wahid F. Bacterial cellulose-zinc oxide nanocomposites as a novel dressing system for burn wounds. Carbohydr Polym. 2017; 164: 214-21.

[11]

Oryan A, Alemzadeh E, Moshiri A. Burn wound healing: present concepts, treatment strategies and future directions. J Wound Care. 2017; 26: 5-19.

[12]

Yang B, Chen Y, Shi J. Reactive oxygen species (ROS)-based nanomedicine. Chem Rev. 2019; 119: 4881-985.

[13]

Zhang Y, Wang T, He J, Dong J. Growth factor therapy in patients with partial-thickness burns: a systematic review and meta-analysis. Int Wound J. 2016; 13: 354-66.

[14]

Shi J, Kantoff PW, Wooster R, Farokhzad OC. Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer. 2017; 17: 20-37.

[15]

Singh AP, Biswas A, Shukla A, Maiti P. Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles. Signal Transduct Tar. 2019; 4: 33. doi: 10.1038/s41392-019-0068-3.

[16]

Yan H, Shao D, Lao YH, Li M, Hu H, Leong KW. Engineering cell membrane-based nanotherapeutics to target inflammation. Adv Sci. 2019; 6: 1900605.

[17]

Makabenta JMV, Nabawy A, Li CH, Schmidt-Malan S, Patel R, Rotello VM. Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections. Nat Rev Microbiol. 2020; 19: 23-36.

[18]

Akhtar A, Andleeb A, Waris TS, Bazzar M, Moradi AR, Awan NR, et al. Neurodegenerative diseases and effective drug delivery: a review of challenges and novel therapeutics. J Control Release. 2020; 330: 1152-67.

[19]

Saleem S, Iqubal MK, Garg S, Ali J, Baboota S. Trends in nanotechnology-based delivery systems for dermal targeting of drugs: an enticing approach to offset psoriasis. Expert Opin Drug Deliv. 2020; 17: 817-38.

[20]

Zhang D, Zhang J. Surface engineering of nanomaterials with phospholipid-polyethylene glycol-derived functional conjugates for molecular imaging and targeted therapy. Biomaterials. 2020; 230: 119646.

[21]

Portela R, Leal CR, Almeida PL, Sobral RG. Bacterial cellulose: a versatile biopolymer for wound dressing applications. J Microbial Biotechnol. 2019; 12: 586-610.

[22]

Sadeghi-Avalshahr AR, Khorsand-Ghayeni M, Nokhasteh S, Molavi AM, Naderi-Meshkin H. Synthesis and characterization of PLGA/collagen composite scaffolds as skin substitute produced by electrospinning through two different approaches. J Mater Sci-Mater M. 2017; 28: 10.

[23]

Jahromi MAM, Zangabad PS, Basri SMM, Zangabad KS, Ghamarypour A, Aref AR, et al. Nanomedicine and advanced technologies for burns: preventing infection and facilitating wound healing. Adv Drug Deliv Rev. 2018; 123: 33-64.

[24]

Chakrabarti S, Islam J, Hazarika H, Mazumder B, Raju PS, Chattopadhyay P. Safety profile of silver sulfadiazine-bFGF-loaded hydrogel for partial thickness burn wounds. Cutan Ocul Toxicol. 2018; 37: 258-66.

[25]

Abazari M, Ghaffari A, Rashidzadeh H, Momeni Badeleh S, Maleki Y. Current status and future outlook of nano-based systems for burn wound management. J Biomed Mater Res B. 2020; 108: 1934-52.

[26]

Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008; 453: 314-21.

[27]

Strbo N, Yin N, Stojadinovic O. Innate and adaptive immune responses in wound epithelialization. Adv Wound Care (New Rochelle). 2014; 3: 492-501.

[28]

Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res. 2012; 49: 35-43.

[29]

Hinz B.Formation and function of the myofibroblast during tissue repair. J Invest Dermatol. 2007; 127: 526-37.

[30]

Edwards R, Harding KG. Bacteria and wound healing. Curr Opin Infect Dis. 2004; 17: 91-6.

[31]

Xiong M, Chen M, Zhang J. Rational evolution of antimicrobial peptides containing unnatural amino acids to combat burn wound infections. Chem Biol Drug Des. 2016; 88: 404-10.

[32]

Gudina EJ, Teixeira JA, Rodrigues LR. Biosurfactants produced by marine microorganisms with therapeutic applications. Mar Drugs. 2016; 14: 38. doi: 10.3390/md14020038.

[33]

Vatansever F, de Melo WCMA, Avci P, Vecchio D, Sadasisvam M, Gupta A, et al. Antimicrobial strategies centered around reactive oxygen species-bactericidal antibiotics, photodynamic therapy, and beyond. FEMS Microbiol Rev. 2013; 37: 955-89.

[34]

Pastar I, Stojadinovic O, Yin NC, Ramirez H, Nusbaum AG, Sawaya A, et al. Epithelialization in wound healing: a comprehensive review. Adv Wound Care (New Rochelle). 2014; 3: 445-64.

[35]

Rahman M, Kamal MA. Special issue: cancer nanotherapeutics: targeted medicine, therapeutic vaccination and challenges with cancer nanomedicines. Semin Cancer Biol. 2021; 69: 1-4.

[36]

Zaidi S, Misba L, Khan AU. Nano-therapeutics: a revolution in infection control in post antibiotic era. Nanomedicine. 2017; 13: 2281-301.

[37]

Kim T, Hyeon T. Applications of inorganic nanoparticles as therapeutic agents. Nanotechnology. 2013; 25: 012001.

[38]

Das S, Baker AB. Biomaterials and nanotherapeutics for enhancing skin wound healing. Front Bioeng Bbiotech. 2016; 4: 82.

[39]

Dai T, Tanaka M, Huang Y-Y, Hamblin MR. Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects. Expert Rev Anti-Infe. 2011; 9: 857-79.

[40]

Forier K, Raemdonck K, De Smedt SC, Demeester J, Coenye T, Braeckmans K. Lipid and polymer nanoparticles for drug delivery to bacterial biofilms. J Control Release. 2014; 190: 607-23.

[41]

Gainza G, Villullas S, Pedraz JL, Hernandez RM, Igartua M. Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration. Nanomed Nanotechnol. 2015; 11: 1551-73.

[42]

Baranwal A, Srivastava A, Kumar P, Bajpai VK, Maurya PK, Chandra P. Prospects of nanostructure materials and their composites as antimicrobial agents. Front Microbiol. 2018; 9: 10. doi: 10.3389/fmicb.2018.00422.

[43]

Sanchez-Lopez E, Gomes D, Esteruelas G, Bonilla L, Lopez-Machado AL, Galindo R, et al. Metal-based nanoparticles as antimicrobial agents: an overview. Nanomaterials. 2020; 10: 39.

[44]

Singh R, Smitha MS, Singh SP. The role of nanotechnology in combating multi-drug resistant bacteria. J Nanosci Nanotechnol. 2014; 14: 4745-56.

[45]

Tang SH, Zheng J. Antibacterial activity of silver nanoparticles: structural effects. Adv Healthc Mater. 2018; 7: 10.

[46]

Burdusel AC, Gherasim O, Grumezescu AM, Mogoanta L, Ficai A, Andronescu E. Biomedical applications of silver nanoparticles: an up-to-date overview. Nanomaterials. 2018; 8: 25.

[47]

Khanna P, Singh N, Charan S, Subbarao V, Gokhale R, Mulik U. Synthesis and characterization of ag/PVA nanocomposite by chemical reduction method. Mater Chem Phys. 2005; 93: 117-21.

[48]

Ahmed KBR, Nagy AM, Brown RP, Zhang Q, Malghan SG, Goering PL. Silver nanoparticles: significance of physicochemical properties and assay interference on the interpretation of in vitro cytotoxicity studies. Toxicol In Vitro. 2017; 38: 179-92.

[49]

Kumar SSD, Rajendran NK, Houreld NN, Abrahamse H. Recent advances on silver nanoparticle and biopolymer-based biomaterials for wound healing applications. Int J Biol Macromol. 2018; 115: 165-75.

[50]

Flores-Lopez LZ, Espinoza-Gomez H, Somanathan R. Silver nanoparticles: electron transfer, reactive oxygen species, oxidative stress, beneficial and toxicological effects. Mini review. J Appl Toxicol. 2019; 39: 16-26.

[51]

Atiyeh BS, Costagliola M, Hayek SN, Dibo SA. Effect of silver on burn wound infection control and healing: review of the literature. Burns. 2007; 33: 139-48.

[52]

Zhang Y, Xu J, Chai Y, Zhang J, Hu Z, Zhou H. Nano-silver modified porcine small intestinal submucosa for the treatment of infected partial-thickness burn wounds. Burns. 2019; 45: 950-56.

[53]

Lansdown ABG.A pharmacological and toxicological profile of silver as an antimicrobial agent in medical devices. Adv Pharm Sci. 2010; 2010: 910686.

[54]

Zhou Y, Chen R, He T, Xu K, Du D, Zhao N, et al. Biomedical potential of ultrafine ag/AgCl nanoparticles coated on graphene with special reference to antimicrobial performances and burn wound healing. ACS Appl Mater Interfaces. 2016; 8: 15067-75.

[55]

Erring M, Gaba S, Mohsina S, Tripathy S, Sharma RK. Comparison of efficacy of silver-nanoparticle gel, nano-silver-foam and collagen dressings in treatment of partial thickness burn wounds. Burns. 2019; 45: 1888-94.

[56]

Kahari VM, Saarialho-Kere U. Matrix metalloproteinases in skin. Exp Dermatol. 1997; 6: 199-213.

[57]

Brodribb AJ, Ricketts CR. The effect of zinc in the healing of burns. Injury. 1971; 3: 25-9.

[58]

Wang XX, Zhang MJ, Li XB. Advances in the research of zinc deficiency and zinc supplementation treatment in patients with severe burns. Zhonghua ShaoShang ZaZhi = Chinese J Burns. 2018; 34: 57-9.

[59]

Arslan K, Karahan O, Okus A, Unlu Y, Eryilmaz MA, Ay S, et al. Comparison of topical zinc oxide and silver sulfadiazine in burn wounds: an experimental study. Ulus Travma Acil Cer. 2012; 18: 376-83.

[60]

Fox CL, Modak SM, Stanford JW. Zinc sulfadiazine for topical therapy of pseudomonas infection in burns. Surg Gynecol Obstet. 1976; 142: 553-9.

[61]

Rath G, Hussain T, Chauhan G, Garg T, Goyal AK. Development and characterization of cefazolin loaded zinc oxide nanoparticles composite gelatin nanofiber mats for postoperative surgical wounds. Mater Sci Eng C. 2016; 58: 242-53.

[62]

Abo-Shama UH, El-Gendy H, Mousa WS, Hamouda RA, Yousuf WE, Hetta HF, et al. Synergistic and antagonistic effects of metal nanoparticles in combination with antibiotics against some reference strains of pathogenic microorganisms. Infect Drug Resist. 2020; 13: 351-62.

[63]

Pati R, Mehta RK, Mohanty S, Padhi A, Sengupta M, Vaseeharan B, et al. Topical application of zinc oxide nanoparticles reduces bacterial skin infection in mice and exhibits antibacterial activity by inducing oxidative stress response and cell membrane disintegration in macrophages. Nanomed Nanotechnol. 2014; 10: 1195-208.

[64]

Arakha M, Saleem M, Mallick BC, Jha S. The effects of interfacial potential on antimicrobial propensity of ZnO nanoparticle. Sci Rep. 2015; 5: 10.

[65]

Zhai MC, Xu YC, Zhou B, Jing WB. Keratin-chitosan/n-ZnO nanocomposite hydrogel for antimicrobial treatment of burn wound healing: characterization and biomedical application. J Photochem Photobiol B. 2018; 180: 253-8.

[66]

Shao F, Yang A, Yu DM, Wang J, Gong X, Tian HX. Biosynthesis of Barleria gibsoni leaf extract mediated zinc oxide nanoparticles and their formulation gel for wound therapy in nursing care of infants and children. J Photochem Photobiol B. 2018; 189: 267-73.

[67]

Elci SG, Jiang Y, Yan B, Kim ST, Saha K, Moyano DF, et al. Surface charge controls the suborgan biodistributions of gold nanoparticles. ACS Nano. 2016; 10: 5536-42.

[68]

Lee J, Kim J, Go J, Lee JH, Han DW, Hwang D, et al. Transdermal treatment of the surgical and burned wound skin via phytochemical-capped gold nanoparticles. Colloids Surf B Biointerfaces. 2015; 135: 166-74.

[69]

Arafa MG, El-Kased RF, Elmazar MM. Thermoresponsive gels containing gold nanoparticles as smart antibacterial and wound healing agents. Sci Rep. 2018; 8: 16.

[70]

Silveira PC, Venancio M, Souza PS, Victor EG, de Souza Notoya F, Paganini CS, et al. Iontophoresis with gold nanoparticles improves mitochondrial activity and oxidative stress markers of burn wounds. Mater Sci Eng C. 2014; 44: 380-5.

[71]

Parkinson LG, Rea SM, Stevenson AW, Wood FM, Fear MW. The effect of nano-scale topography on keratinocyte phenotype and wound healing following burn injury. Tissue Eng Part A. 2012; 18: 703-14.

[72]

Fenton OS, Olafson KN, Pillai PS, Mitchell MJ, Langer R. Advances in biomaterials for drug delivery. Adv Mater. 2018; 30: 1705328.

[73]

Nitta SK, Numata K. Biopolymer-based nanoparticles for drug/gene delivery and tissue engineering. Int J Mol Sci. 2013; 14: 1629-54.

[74]

Bamburowicz-Klimkowska M, Poplawska M, Grudzinski IP. Nanocomposites as biomolecules delivery agents in nanomedicine. J Nanobiotechnol. 2019; 17: 48.

[75]

Ahmadi F, Oveisi Z, Samani SM, Amoozgar Z. Chitosan based hydrogels: characteristics and pharmaceutical applications. Res Pharm Sci. 2015; 10: 1-16.

[76]

Ulański P, Kadłubowski S, Rosiak JM. Synthesis of poly(acrylic acid) nanogels by preparative pulse radiolysis. Radiat Phys Chem. 2002; 63: 533-7.

[77]

Anjum S, Patra S, Gupta B. Preparation and bactericidal action of biofunctional polyacrylamide nanogels. Adv Mater Let. 2017; 8: 13-8.

[78]

Kim J-S, Kim M, Won D-A, Tae G. Preparation of nanosize alginate gel using pluronic-based nano-carrier as a template. Eur Polym J. 2015; 72: 632-41.

[79]

Debele TA, Mekuria SL, Tsai H-C. Polysaccharide based nanogels in the drug delivery system: application as the carrier of pharmaceutical agents. Mater Sci Eng C. 2016; 68: 964-81.

[80]

Burd A.Evaluating the use of hydrogel sheet dressings in comprehensive burn wound care. Ostomy Wound Manage. 2007; 53: 52-62.

[81]

Grippaudo FR, Carini L, Baldini R. Procutase (R) versus 1% silver sulphadiazine in the treatment of minor burns. Burns. 2010; 36: 871-5.

[82]

Hashmi MU, Khan F, Khalid N, Shahid AA, Javed A, Alam T, et al. Hydrogels incorporated with silver nanocolloids prepared from antioxidant rich Aerva javanica as disruptive agents against burn wound infections. Colloid Surface A. 2017; 529: 475-86.

[83]

Zia T, Usman M, Sabir A, Shafiq M, Khan RU. Development of inter-polymeric complex of anionic polysaccharides, alginate/k-carrageenan bio-platform for burn dressing. Int J Biol Macromol. 2020; 157: 83-95.

[84]

Barkat MA, Harshita, Pottoo FH, Singh SP, Ahmad FJ. Therapeutic intervention of aloe gel containing nano-sized and micron-sized silver sulfadiazine gel on second-degree burn: a comparative study. Int J Low Extrem Wounds. 2018; 17: 176-83.

[85]

Thanusha AV, Dinda AK, Koul V. Evaluation of nano hydrogel composite based on gelatin/HA/CS suffused with Asiatic acid/ZnO and CuO nanoparticles for second degree burns. Mater Sci Eng C. 2018; 89: 378-86.

[86]

Dang LH, Huynh NT, Pham NO, Nguyen CT, Vu MT, Dinh VT, et al. Injectable nanocurcumin-dispersed gelatin-pluronic nanocomposite hydrogel platform for burn wound treatment. B Mater Sci. 2019; 42: 71. doi: 10.1007/s12034-019-1745-0.

[87]

Choi JS, Yoo HS. Pluronic/chitosan hydrogels containing epidermal growth factor with wound-adhesive and photo-crosslinkable properties. J Biomed Mater Res A. 2010; 95A: 564-73.

[88]

Loo Y, Wong YC, Cai EZ, Ang CH, Raju A, Lakshmanan A, et al. Ultrashort peptide nanofibrous hydrogels for the acceleration of healing of burn wounds. Biomaterials. 2014; 35: 4805-14.

[89]

Devi MV, Sobhana SSL, Shiny PJ, Ramanathan G, Felciya SJG, Poornima V, et al. Durable nanofibrous matrices augmented with hydrotalcite-like compounds for cutaneous regeneration of burn wounds. Appl Clay Sci. 2020; 187: 15.

[90]

Abd Elhaleem MB, Farghali AA, el-Shahawy AAG, Abo el-Ela FI, Eldine ZE, Mahmoud RK. Chemisorption and sustained release of cefotaxime between a layered double hydroxide and polyvinyl alcohol nanofibers for enhanced efficacy against second degree burn wound infection. RSC Adv. 2020; 10: 13196-214.

[91]

Hajiali H, Summa M, Russo D, Armirotti A, Brunetti V, Bertorelli R, et al. Alginate-lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing. J Mater Chem B. 2016; 4: 1686-95.

[92]

Romano I, Summa M, Heredia-Guerrero JA, Spano R, Ceseracciu L, Pignatelli C, et al. Fumarate-loaded electrospun nanofibers with anti-inflammatory activity for fast recovery of mild skin burns. Biomed Mater. 2016; 11: 041001.

[93]

Dhand C, Venkatesh M, Barathi VA, Harini S, Bairagi S, Goh Tze Leng E, et al. Bio-inspired crosslinking and matrix-drug interactions for advanced wound dressings with long-term antimicrobial activity. Biomaterials. 2017; 138: 153-68.

[94]

Hadisi Z, Nourmohammadi J, Nassiri SM. The antibacterial and anti-inflammatory investigation of Lawsonia Inermis-gelatin-starch nano-fibrous dressing in burn wound. Int J Biol Macromol. 2018; 107: 2008-19.

[95]

Zhou ST, Hokugo A, McClendon M, Zhang ZY, Bakshi REN, Wang LX, et al. Bioactive peptide amphiphile nanofiber gels enhance burn wound healing. Burns. 2019; 45: 1112-21.

[96]

Wang WD, Liu GJ, Liu M, Li XB. Mechanisms underlying the action of self-assembling short-peptide nano-fiber gel scaffold materials in the aesthetic repair of burn wounds. Mater Express. 2020; 10: 454-9.

[97]

Yergoz F, Hastar N, Cimenci CE, Ozkan AD, Tekinay T, Guler MO, et al. Heparin mimetic peptide nanofiber gel promotes regeneration of full thickness burn injury. Biomaterials. 2017; 134: 117-27.

[98]

Ito K, Saito A, Fujie T, Nishiwaki K, Miyazaki H, Kinoshita M, et al. Sustainable antimicrobial effect of silver sulfadiazine-loaded nanosheets on infection in a mouse model of partial-thickness burn injury. Acta Biomater. 2015; 24: 87-95.

[99]

Luna-Hernández E, Cruz-Soto ME, Padilla-Vaca F, Mauricio-Sánchez RA, Ramirez-Wong D, Muñoz R, et al. Combined antibacterial/tissue regeneration response in thermal burns promoted by functional chitosan/silver nanocomposites. Int J Biol Macromol. 2017; 105: 1241-9.

[100]

Xi P, Li Y, Ge XJ, Liu DD, Miao MS. Effect of nano-silver hydrogel coating film on deep partial thickness scald model of rabbit. Saudi J Biol Sci. 2018; 25: 797-800.

[101]

Castleberry SA, Golberg A, Sharkh MA, Khan S, Almquist BD, Austen WG, et al. Nanolayered siRNA delivery platforms for local silencing of CTGF reduce cutaneous scar contraction in third-degree burns. Biomaterials. 2016; 95: 22-34.

[102]

Ju HW, Lee OJ, Lee JM, Moon BM, Park HJ, Park YR, et al. Wound healing effect of electrospun silk fibroin nanomatrix in burn-model. Int J Biol Macromol. 2016; 85: 29-39.

[103]

Krishnamoorthy R, Athinarayanan J, Periasamy VS, Adisa AR, Al-Shuniaber MA, Gassem MA, et al. Antimicrobial activity of nanoemulsion on drug-resistant bacterial pathogens. Microb Pathog. 2018; 120: 85-96.

[104]

Long Y, Huang W, Wang Q, Yang G. Green synthesis of garlic oil nanoemulsion using ultrasonication technique and its mechanism of antifungal action against Penicillium italicum. Ultrason Sonochem. 2020; 64: 104970.

[105]

Franklyne JS, Ebenazer LA, Mukherjee A, Natarajan C. Cinnamon and clove oil nanoemulsions: novel therapeutic options against vancomycin intermediate susceptible Staphylococcus aureus. Appl Nanosci. 2019; 9: 11.

[106]

Hamouda T, Hayes MM, Cao Z, Tonda R, Johnson K, Wright DC, et al. A novel surfactant nanoemulsion with broad-spectrum sporicidal activity against bacillus species. J Infect Dis. 1999; 180: 1939-49.

[107]

Hemmila MR, Mattar A, Taddonio MA, Arbabi S, Hamouda T, Ward PA, et al. Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury. Surgery. 2010; 148: 499-509.

[108]

Song Z, Sun HW, Yang Y, Jing HM, Yang LY, Tong YN, et al. Enhanced efficacy and anti-biofilm activity of novel nanoemulsions against skin burn wound multi-drug resistant MRSA infections. Nanomed-Nanotechnol. 2016; 12: 1543-55.

[109]

Thakur K, Sharma G, Singh B, Jain A, Tyagi R, Chhibber S, et al. Cationic-bilayered nanoemulsion of fusidic acid: an investigation on eradication of methicillin-resistant Staphylococcus aureus 33591 infection in burn wound. Nanomedicine. 2018; 13: 825-47.

[110]

Dolgachev VA, Ciotti SM, Eisma R, Gracon S, Wilkinson JE, Baker JR, et al. Nanoemulsion therapy for burn wounds is effective as a topical antimicrobial against gram-negative and gram-positive bacteria. J Burn Care Res. 2016; 37: E104-14.

[111]

Maurer HR.Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001; 58: 1234-45.

[112]

Rachmawati H, Sulastri E, Iwo MI, Safitri D, Rahma A. Bromelain encapsulated in self assembly nanoemulsion exhibits better debridement effect in animal model of burned skin. J Nanopart Res. 2016; 40: 158.

[113]

Manca ML, Matricardi P, Cencetti C, Peris JE, Melis V, Carbone C, et al. Combination of argan oil and phospholipids for the development of an effective liposome-like formulation able to improve skin hydration and allantoin dermal delivery. Int J Pharm. 2016; 505: 204-11.

[114]

Lu KJ, Wang W, Xu XL, Jin FY, Qi J, Wang XJ, et al. A dual deformable liposomal ointment functionalized with retinoic acid and epidermal growth factor for enhanced burn wound healing therapy. Biomater Sci. 2019; 7: 2372-82. doi: 10.1039/C8BM01569D.

[115]

Verbist L.The antimicrobial activity of fusidic acid. J Antimicrob Chemother. 1990; 25: 1-5.

[116]

Thakur K, Sharma G, Singh B, Chhibber S, Katare OP. Nano-engineered lipid-polymer hybrid nanoparticlesof fusidic acid: an investigative study on dermatokinetics profile and MRSA-infected burn wound model. Drug Deliv Transl Res. 2019; 9: 748-63.

[117]

Li XY, Wei ZH, Li BX, Li J, Lv HY, Wu LY, et al. In vivo migration of Fe3O4@polydopamine nanoparticle-labeled mesenchymal stem cells to burn injury sites and their therapeutic effects in a rat model. Biomater Sci. 2019; 7: 2861-72.

[118]

Liu XL, Hao W, Lok CN, Wang YC, Zhang RZ, Wong KKY. Dendrimer encapsulation enhances anti-inflammatory efficacy of silver nanoparticles. J Pediatr Surg. 2014; 49: 1846-51.

[119]

Zhang C, Li Y, Hu Y, Peng Y, Ahmad Z, Li JS, et al. Porous yolk-shell particle engineering via nonsolvent-assisted trineedle coaxial electrospraying for burn-related wound healing. ACS Appl Mater Interfaces. 2019; 11: 7823-35.

[120]

Kang YO, Jung J-Y, Cho D, Kwon OH, Cheon JY, Park WH. Antimicrobial silver chloride nanoparticles stabilized with chitosan oligomer for the healing of burns. Materials. 2016; 9: 215. doi: 10.3390/ma9040215.

[121]

Gholipour-Kanani A, Mohsenzadegan M, Fayyazi M, Bahrami H, Samadikuchaksaraei A. Poly(ε-caprolactone)-chitosan-poly(vinyl alcohol) nanofibrous scaffolds for skin excisional and burn wounds in a canine model. IET Nanobiotechnol. 2018; 12: 619-25.

[122]

Oryan A, Alemzadeh E, Tashkhourian J, Ana SFN. Topical delivery of chitosan-capped silver nanoparticles speeds up healing in burn wounds: a preclinical study. Carbohydr Polym. 2018; 200: 82-92.

[123]

Sood R, Chopra DS. Optimization of reaction conditions to fabricate Ocimum sanctum synthesized silver nanoparticles and its application to nano-gel systems for burn wounds. Mater Sci Eng C. 2018; 92: 575-89.

[124]

Wen X, Zheng Y, Jian W, Yue L, Cai W, Luan J, et al. In vitro and in vivo investigation of bacterial cellulose dressing containing uniform silver sulfadiazine nanoparticles for burn wound healing. Prog Nat Sci Mater. 2015; 25: 197-203.

[125]

Mu B, Wang RF, Gao J, Li ZY, Li X. Nano gold incorporated into Aerva javanica chitosan hydrogels disrupting agents against infections of burn wound. Mater Technol. 2020; 9: 1-10.

[126]

Konieczynska MD, Villa-Camacho JC, Ghobril C, Perez-Viloria M, Tevis KM, Blessing WA, et al. On-demand dissolution of a dendritic hydrogel-based dressing for second-degree burn wounds through thiol-thioester exchange reaction. Angew Chem Int Ed. 2016; 55: 9984-7.

[127]

Rezaei F, Damoogh S, Reis RL, Kundu SC, Mottaghitalab F, Farokhi M. Dual drug delivery system based on pH-sensitive silk fibroin/alginate nanoparticles entrapped in PNIPAM hydrogel for treating severe infected burn wound. Biofabrication. 2020; 13: 015005.

[128]

Gholipour-Kanani A, Bahrami SH, Joghataie MT, Samadikuchaksaraei A, Ahmadi-Taftie H, Rabbani S, et al. Tissue engineered poly(caprolactone)-chitosan-poly(vinyl alcohol) nanofibrous scaffolds for burn and cutting wound healing. IET Nanobiotechnol. 2014; 8: 123-31.

[129]

Saito A, Miyazaki H, Fujie T, Ohtsubo S, Kinoshita M, Saitoh D, et al. Therapeutic efficacy of an antibiotic-loaded nanosheet in a murine burn-wound infection model. Acta Biomater. 2012; 8: 2932-40.

[130]

Mohebali A, Abdouss M. Layered biocompatible pH-responsive antibacterial composite film based on HNT/PLGA/chitosan for controlled release of minocycline as burn wound dressing. Int J Biol Macromol. 2020; 164: 4193-204.

[131]

Chhibber S, Gondil VS, Singla L, Kumar M, Chhibber T, Sharma G, et al. Effective topical delivery of H-AgNPs for eradication of klebsiella pneumoniae-induced burn wound infection. AAPS PharmSciTech. 2019; 20: 13.

[132]

Kurowska A, Ghate V, Kodoth A, Shah A, Shah A, Vishalakshi B, et al. Non-propellant foams of green nano-silver and sulfadiazine: development and in vivo evaluation for burn wounds. Pharm Res. 2019; 36: 18.

[133]

Kalita S, Kandimalla R, Devi B, Kalita B, Kalita K, Deka M, et al. Dual delivery of chloramphenicol and essential oil by poly-ε-caprolactone-Pluronic nanocapsules to treat MRSA-Candida co-infected chronic burn wounds. RSC Adv. 2017; 7: 1749-58.

[134]

Yang YT, Chien HF, Chang PH, Chen YC, Jay M, Tsai TM, et al. Photodynamic inactivation of chlorin e6-loaded CTAB-liposomes against Candida albicans. Lasers Surg Med. 2013; 45: 175-85.

[135]

Xu H-L, Chen P-P, ZhuGe D-L, Zhu Q-Y, Jin B-H, Shen B-X, et al. Liposomes with silk fibroin hydrogel core to stabilize bFGF and promote the wound healing of mice with deep second-degree scald. Adv Healthc Mater. 2017; 6: 1700344.

[136]

Pereira CT, Herndon DN, Rocker R, Jeschke MG. Liposomal gene transfer of keratinocyte growth factor improves wound healing by altering growth factor and collagen expression. J Surg Res. 2007; 139: 222-8.

PDF (2255KB)

19

Accesses

0

Citation

Detail

Sections
Recommended

/

〈 〉