The potential applications of artificial intelligence in biomarker discovery for cardiovascular diseases

Kyriacos Felekkis , Christos Papaneophytou

Brain & Heart ›› 2025, Vol. 3 ›› Issue (3) : 8442

PDF (372KB)
Brain & Heart ›› 2025, Vol. 3 ›› Issue (3) :8442 DOI: 10.36922/bh.8442
PERSPECTIVE ARTICLE
research-article
The potential applications of artificial intelligence in biomarker discovery for cardiovascular diseases
Author information +
History +
PDF (372KB)

Abstract

Cardiovascular diseases (CVDs) are the leading global cause of early mortality and disability, characterized by their complex, multifactorial nature, which demands personalized diagnostic and therapeutic strategies. Current diagnostic methods for CVDs, while essential, have limitations in sensitivity, specificity, and real-time monitoring, which can impede early and accurate disease detection. Biomarkers emerge as pivotal tools for the enhanced diagnosis and management of CVDs, yet the challenges in their discovery and validation persist. Integrating artificial intelligence with omics technologies promises to revolutionize this field by significantly improving the precision and speed of biomarker discovery. This innovative approach, merging the analysis of genetic variants with expression patterns linked to specific phenotypes, holds the potential to uncover novel biomarkers and facilitate the stratification of patient groups based on individual risk factors, thereby advancing personalized medicine in cardiovascular care.

Keywords

Cardiovascular diseases / Biomarkers / Artificial intelligence / Omics technologies / Diagnostic accuracy

Cite this article

Download citation ▾
Kyriacos Felekkis, Christos Papaneophytou. The potential applications of artificial intelligence in biomarker discovery for cardiovascular diseases. Brain & Heart, 2025, 3(3): 8442 DOI:10.36922/bh.8442

登录浏览全文

4963

注册一个新账户 忘记密码

Acknowledgments

None.

Funding

None.

Conflict of interest

The authors declare that they have no competing interests.

Author contributions

Conceptualization: All authors

Writing - original draft: Christos Papaneophytou

Writing - review & editing: All authors

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Availability of data

Not applicable.

References

[1]

Flora GD, Nayak MK. A brief review of cardiovascular diseases, associated risk factors and current treatment regimes. Curr Pharm Des. 2019; 25(38):4063-4084. doi: 10.2174/1381612825666190925163827

[2]

Pang W, Yuan C, Zhong T, et al. Diagnostic and therapeutic optical imaging in cardiovascular diseases. iScience. 2024; 27(11):111216. doi: 10.1016/j.isci.2024.111216

[3]

Harskamp RE. Electrocardiographic screening in primary care for cardiovascular disease risk and atrial fibrillation. Prim Health Care Res Dev. 2019; 20:e101. doi: 10.1017/s1463423619000355

[4]

Netala VR, Teertam SK, Li H, Zhang Z. A comprehensive review of cardiovascular disease management: Cardiac biomarkers, imaging modalities, pharmacotherapy, surgical interventions, and herbal remedies. Cells. 2024; 13(17):1471. doi: 10.3390/cells13171471

[5]

Kim SJ, Mesquita FCP, Hochman-Mendez C.New biomarkers for cardiovascular disease. Tex Heart Inst J. 2023; 50(5):e238178. doi: 10.14503/thij-23-8178

[6]

Dhingra R, Vasan RS. Biomarkers in cardiovascular disease: Statistical assessment and section on key novel heart failure biomarkers. Trends Cardiovasc Med. 2017; 27(2):123-133. doi: 10.1016/j.tcm.2016.07.005

[7]

Group BDW. Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001; 69(3):89-95. doi: 10.1067mcp.2001.113989

[8]

Strimbu K, Tavel JA. What are biomarkers? Curr Opin HIV AIDS. 2010; 5(6):463-466. doi: 10.1097/COH.0b013e32833ed177

[9]

Jacob R, Khan M. Cardiac biomarkers: What is and what can be. Indian J Cardiovasc Dis Women WINCARS. 2018; 3(4):240-244. doi: 10.1055/s-0039-1679104

[10]

Matthews H, Hanison J, Nirmalan N. “Omics”-informed drug and biomarker biscovery: Opportunities, challenges and future perspectives. Proteomes. 2016; 4(3):28. doi: 10.3390/proteomes4030028

[11]

Felekkis K, Papaneophytou C. Challenges in using circulating micro-RNAs as biomarkers for cardiovascular diseases. Int J Mol Sci. 2020; 21(2):561. doi: 10.3390/ijms21020561

[12]

Felekkis K, Papaneophytou C. The circulating biomarkers league: Combining miRNAs with cell-free DNAs and proteins. Int J Mol Sci. 2024; 25(6):3403. doi: 10.3390/ijms25063403

[13]

Chustecki M. Benefits and risks of AI in health care: Narrative review. Interact J Med Res. 2024; 13:e53616. doi: 10.2196/53616

[14]

Topol EJ. High-performance medicine: The convergence of human and artificial intelligence. Nat Med. 2019; 25(1):44-56. doi: 10.1038/s41591-018-0300-7

[15]

Khera R, Oikonomou EK, Nadkarni GN, et al. Transforming cardiovascular care with artificial intelligence: From discovery to practice. J Am Coll Cardiol. 2024; 84(1):97-114. doi: 10.1016/j.jacc.2024.05.003

[16]

Sun X, Yin Y, Yang Q, Huo T. Artificial intelligence in cardiovascular diseases: Diagnostic and therapeutic perspectives. Eur J Med Res. 2023; 28(1):242. doi: 10.1186/s40001-023-01065-y

[17]

DeGroat W, Abdelhalim H, Patel K, Mendhe D, Zeeshan S, Ahmed Z. Discovering biomarkers associated and predicting cardiovascular disease with high accuracy using a novel nexus of machine learning techniques for precision medicine. Sci Rep. 2024; 14(1):1. doi: 10.1038/s41598-023-50600-8

[18]

Batta I, Patial R, Sobti RC, Agrawal DK. Computational biology in the discovery of biomarkers in the diagnosis, treatment and management of cardiovascular diseases. Cardiol Cardiovasc Med. 2024; 8(5):405-414.

PDF (372KB)

34

Accesses

0

Citation

Detail

Sections
Recommended

/