Multidisciplinary expert consensus on clinical diagnosis and therapies for low back pain

Bo Gao , Rundong Chai , Guanyi Wang , Yanfang Song , Lei Shang , Jinghui Huang , Xu Cao , Yong Hai , Zhuojing Luo , Chinese Society for the Study of the Lumbar Spine, Chinese Association of Spine , Yong Hai , Zhongqiang Chen , Shiqing Feng , Jianyuan Jiang , Fang Li , Li Li , Zhuojing Luo , Yueming Song , Zhaomin Zheng , Jun Ao , Yunbing Chang , Bohua Chen , Deyu Chen , Jianting Chen , Liang Chen , Qixin Chen , Shaoqian Cui , Shucai Deng , Huiqiang Ding , Guiyou Feng , Yanzheng Gao , Tao Guo , Zhaoqing Guo , Qing He , Baorong He , Shisheng He , Yi Hong , Zhenghua Hong , Congren Huang , Han Jiang , Dianming Jiang , Bo Li , Chunde Li , Fangcai Li , Feng Li , Ming Li , Zhongshi Li , Yu Liang , Baoge Liu , Bo Liu , Haiying Liu , Hao Liu , Hongjian Liu , Yang Liu , Yang Liu , Yuzeng Liu , Shibao Lu , Feizhou Lv , Xuexiao Ma , Haiqing Mao , Wei Mei , Zhibin Meng , Lin Nie , Baogan Peng , Qiang Qi , Bangping Qian , Longxi Ren , Dike Ruan , Zengwu Shao , Cailiang Shen , Yong Shen , Weibin Sheng , Jiangang Shi , Changtai Sun , Zhiming Sun , Xun Tang , Ye Tian , Feng Wang , Huadong Wang , Huan Wang , Peng Wang , Zhe Wang , Zili Wang , Wenwen Wu , Yongchao Wu , Zenghui Wu , Ji Wu , Chunyang Xi , Qun Xia , Jie Xiao , Zengming Xiao , Huazi Xu , Jianguang Xu , Jianzhong Xu , Jinglong Yan , Huilin Yang , Qun Yang , Zhengxu Ye , Guoyong Yin , Qiang Zhang , Wenzhi Zhang , Zhongmin Zhang , Guangmin Zhao , Jie Zhao , Changqing Zhao , Qiang Zhou , Yue Zhou , Qingsan Zhu , Yue Zhu

Bone Research ›› 2026, Vol. 14 ›› Issue (1) : 92

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Bone Research ›› 2026, Vol. 14 ›› Issue (1) :92 DOI: 10.1038/s41413-026-00572-y
Consensus Statement
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Multidisciplinary expert consensus on clinical diagnosis and therapies for low back pain
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Abstract

Low back pain (LBP) is one of the most frequently encountered conditions in orthopedics, physical therapy and rehabilitation, and pain medicine. Its etiology is multifactorial and its management options are diverse. However, a unified, standardized, and evidence-based clinical pathway for LBP remains lacking, leading to substantial variation in diagnostic reasoning, treatment selection, outcome assessment, and long-term care across healthcare settings and professional disciplines. To address this gap, Chinese Society for the Study of the Lumbar Spine, Chinese Association of Spine initiated this multidisciplinary expert consensus. The project was organized and implemented by Xijing Hospital of Fourth Military Medical University and Beijing Chaoyang Hospital of Capital Medical University, in collaboration with a national multicenter panel of clinical experts and methodologists. Using rigorous evidence-based methodology, the panel developed an expert consensus on recommendation levels for clinical diagnosis and treatment pathways in LBP. Comprehensive searches of multiple databases and guideline sources were performed from 1991 to December 2025 in this consensus. A total of 4 703 publications were initially retrieved, and 653 publications were ultimately selected to inform the development of the consensus statements, including 70 systematic reviews and 145 original studies that directly supported the formulation and grading of recommendations. Centered on key elements across the entire care continuum, including precise diagnostic assessment, stepwise treatment selection, multimodal comprehensive interventions, long-term outcome management, recurrence prevention, patient education, and self-management, this consensus provides a structured set of recommendations. It clarifies the core diagnostic criteria and intervention strategies for patients with low back pain caused by different etiologies, and classifies interventions as “strong recommendation”, “weak recommendation”, “weak recommendation against”, or “strong recommendation against”. The recommendations emphasize individualized and stepwise decision-making tailored to patient-specific circumstances, reaffirm the foundational role of conservative management, and define strict indications for surgery and other invasive interventions. In addition, the consensus evaluates the potential synergistic effects of combined treatment strategies and highlights the importance of recurrence prevention and functional rehabilitation in long-term care. It also provides guidance on multidisciplinary collaboration and referral criteria within the clinical pathway. Overall, this consensus aims to provide clinicians at all levels of healthcare with a clear and authoritative decision-making framework. By promoting a shift from experience-based and fragmented practice toward systematic, standardized, and evidence-based management, this consensus is expected to improve clinical outcomes, enhance patients’ quality of life, and support more efficient use and distribution of healthcare resources.

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Bo Gao, Rundong Chai, Guanyi Wang, Yanfang Song, Lei Shang, Jinghui Huang, Xu Cao, Yong Hai, Zhuojing Luo, Chinese Society for the Study of the Lumbar Spine, Chinese Association of Spine, Yong Hai, Zhongqiang Chen, Shiqing Feng, Jianyuan Jiang, Fang Li, Li Li, Zhuojing Luo, Yueming Song, Zhaomin Zheng, Jun Ao, Yunbing Chang, Bohua Chen, Deyu Chen, Jianting Chen, Liang Chen, Qixin Chen, Shaoqian Cui, Shucai Deng, Huiqiang Ding, Guiyou Feng, Yanzheng Gao, Tao Guo, Zhaoqing Guo, Qing He, Baorong He, Shisheng He, Yi Hong, Zhenghua Hong, Congren Huang, Han Jiang, Dianming Jiang, Bo Li, Chunde Li, Fangcai Li, Feng Li, Ming Li, Zhongshi Li, Yu Liang, Baoge Liu, Bo Liu, Haiying Liu, Hao Liu, Hongjian Liu, Yang Liu, Yang Liu, Yuzeng Liu, Shibao Lu, Feizhou Lv, Xuexiao Ma, Haiqing Mao, Wei Mei, Zhibin Meng, Lin Nie, Baogan Peng, Qiang Qi, Bangping Qian, Longxi Ren, Dike Ruan, Zengwu Shao, Cailiang Shen, Yong Shen, Weibin Sheng, Jiangang Shi, Changtai Sun, Zhiming Sun, Xun Tang, Ye Tian, Feng Wang, Huadong Wang, Huan Wang, Peng Wang, Zhe Wang, Zili Wang, Wenwen Wu, Yongchao Wu, Zenghui Wu, Ji Wu, Chunyang Xi, Qun Xia, Jie Xiao, Zengming Xiao, Huazi Xu, Jianguang Xu, Jianzhong Xu, Jinglong Yan, Huilin Yang, Qun Yang, Zhengxu Ye, Guoyong Yin, Qiang Zhang, Wenzhi Zhang, Zhongmin Zhang, Guangmin Zhao, Jie Zhao, Changqing Zhao, Qiang Zhou, Yue Zhou, Qingsan Zhu, Yue Zhu. Multidisciplinary expert consensus on clinical diagnosis and therapies for low back pain. Bone Research, 2026, 14 (1) : 92 DOI:10.1038/s41413-026-00572-y

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References

[1]

Cheng M, et al.. Global, regional, and national burden of low back pain: findings from the global burden of disease study 2021 and projections to 2050. Spine, 2025, 50: E128-E139

[2]

Zhang C, Qin L, Yin F, Chen Q, Zhang S. Global, regional, and national burden and trends of Low back pain in middle-aged adults: analysis of GBD 1990–2021 with projections to 2050. BMC Musculoskelet. Disord., 2024, 25 886

[3]

Hassan S, et al.. Identifying chronic low back pain phenotypic domains and characteristics accounting for individual variation: a systematic review. Pain, 2023, 164: 2148-2190

[4]

Kaneda G, et al.. What a pain in the back: etiology, diagnosis and future treatment directions for discogenic low back pain. Bone Res, 2025, 13: 89

[5]

Zhou T, Salman D, McGregor AH. Recent clinical practice guidelines for the management of low back pain: a global comparison. BMC Musculoskelet. Disord., 2024, 25 344

[6]

Nijs J, et al.. Nociceptive, neuropathic, or nociplastic low back pain? The low back pain phenotyping (BACPAP) consortium’s international and multidisciplinary consensus recommendations. Lancet Rheumatol, 2024, 6: e178-e188

[7]

Boney O, et al.. Core outcome measures for perioperative and anaesthetic care (COMPAC): a modified Delphi process to develop a core outcome set for trials in perioperative care and anaesthesia. Br. J. Anaesth., 2022, 128: 174-185

[8]

Chen Q, Wang Z, Zhang S. Mechanism, application and effect evaluation of nerve mobilization in the treatment of low back pain: a narrative review. Medicine, 2023, 102: e34961

[9]

de Vet HC, et al.. Episodes of low back pain: a proposal for uniform definitions to be used in research. Spine, 2002, 27: 2409-2416

[10]

D’Antoni F, et al.. Artificial intelligence and computer aided diagnosis in chronic low back pain: A systematic review. Int. J. Environ. Res. Public Health, 2022, 19: 5971

[11]

Ferreira ML, et al.. Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol, 2023, 5: e316-e329

[12]

Kent P, et al.. Cognitive functional therapy with or without movement sensor biofeedback versus usual care for chronic, disabling low back pain (RESTORE): a randomised, controlled, three-arm, parallel group, phase 3, clinical trial. Lancet, 2023, 401: 1866-1877

[13]

Thiveos L, Kent P, Pocovi NC, O’Sullivan P, Hancock MJ. Cognitive functional therapy for chronic low back pain: a systematic review and meta-analysis. Phys. Ther, 2024, 104: pzae128

[14]

Ma X, Chen R, Li W, Huang P. A systematic review and meta-analysis of pain neuroscience education for chronic low back pain: short-term outcomes of pain and disability. Physiother. Theory Pract., 2024, 40: 2130-2149

[15]

Medina-Viedma L, et al.. Effectiveness of pain neuroscience education in reducing pain, disability, kinesiophobia, and catastrophizing in patients with chronic low back pain: a systematic review and meta-analysis. Med. Sci., 2025, 13: 290

[16]

Greff Ballejos K, Calvetti , Schaab BL, Reppold CT. What are the benefits of cultivating self-compassion in adults with low back pain? A systematic review - PubMed. Front. Psychol., 2023, 14: 1270287

[17]

Godfrey E, et al.. Physical Therapy informed by acceptance and commitment therapy (PACT) versus usual care physical therapy for adults with chronic low back pain: a randomized controlled trial. J. Pain., 2020, 21: 71-81

[18]

Akinrolie O, et al.. Effect of motivational interviewing and exercise on chronic low back pain: a systematic review and meta-analysis. Musculoskelet. Care, 2025, 23: e70048

[19]

Hardt S, Griefahn A, Aasdahl L, Armijo-Olivo S. Effectiveness of motivational interviewing on pain-related outcomes in patients with musculoskeletal pain: a systematic review and meta-analysis. Disabil. Rehabil., 2025, 47: 4341-4365

[20]

Cherkin DC, et al.. Effect of mindfulness-based stress reduction vs cognitive behavioral therapy or usual care on back pain and functional limitations in adults with chronic low back pain: a randomized clinical trial. JAMA, 2016, 315: 1240-1249

[21]

M P, et al.. Mindfulness-based interventions for chronic low back pain: a systematic review and meta-analysis. Clin. J. Pain, 2024, 40: 105-113

[22]

Luomajoki HA, Bonet Beltran MB, Careddu S, Bauer CM. Effectiveness of movement control exercise on patients with non-specific low back pain and movement control impairment: a systematic review and meta-analysis. Musculoskelet. Sci. Pract, 2018, 36: 1-11

[23]

George SZ, et al.. Interventions for the management of acute and chronic low back pain: revision 2021. J. Orthop. Sports Phys. Ther, 2021, 51: CPG1-CPG60

[24]

Drummond C, Lebedeva V, Kirker K, Masaracchio M. Sling exercise in the management of chronic low back pain: a systematic review and meta-analysis. J. Strength Cond. Res, 2024, 38: 1822-1833

[25]

Kim YW, Kim NY, Chang WH, Lee SC. Comparison of the therapeutic effects of a sling exercise and a traditional stabilizing exercise for clinical lumbar spinal instability. J. Sport Rehabil., 2018, 27: 47-54

[26]

Arcanjo FL, et al.. Proprioceptive neuromuscular facilitation training reduces pain and disability in individuals with chronic low back pain: a systematic review and meta-analysis. Complement. Ther. Clin. Pract., 2022, 46: 101505

[27]

Hennemann V, Ziegelmann PK, Marcolino MAZ, Duncan BB. The McKenzie method delivered by credentialed therapists for chronic low back pain with directional preference: systematic review with meta-analysis. J. Man Manip. Ther, 2025, 33: 96-111

[28]

Lam OT, et al.. Effectiveness of the McKenzie method of mechanical diagnosis and therapy for treating low back pain: literature review with meta-analysis. J. Orthop. Sports Phys. Ther., 2018, 48: 476-490

[29]

Liu Y, Liu J, Liu M, Wang M. The effect of blood flow restriction training on core muscle strength and pain in male collegiate athletes with chronic non-specific low back pain. Front. Public Health, 2024, 12: 1496482

[30]

Ma J, et al.. Effect of aquatic physical therapy on chronic low back pain: a systematic review and meta-analysis. BMC Musculoskelet. Disord., 2022, 23 14

[31]

George SZ, et al.. Interventions for the management of acute and chronic low back pain: revision 2021 clinical practice guidelines linked to the international classification of functioning, disability and health from the academy of orthopaedic physical therapy of the american physical therapy association. J. Orthop. Sports Phys. Ther, 2021, 51: CPG1-CPG60

[32]

Patti A, et al.. Effectiveness of Pilates exercise on low back pain: a systematic review with meta-analysis. Disabil. Rehabil., 2024, 46: 3535-3548

[33]

Wong CM, Rugg B, Geere JA. The effects of Pilates exercise in comparison to other forms of exercise on pain and disability in individuals with chronic non-specific low back pain: a systematic review with meta-analysis. Musculoskelet. Care, 2023, 21: 78-96

[34]

Li Y, et al.. Exercise intervention for patients with chronic low back pain: a systematic review and network meta-analysis. Front. Public Health, 2023, 11: 1155225

[35]

Zou L, Yeung A, Quan X, Boyden SD, Wang H. A Systematic review and meta-analysis of mindfulness-based (Baduanjin) exercise for alleviating musculoskeletal pain and improving sleep quality in people with chronic diseases. Int. J. Environ. Res. Public Health, 2018, 15: 206

[36]

Lin, Y., Guan, S. & Gao, K. Effect of traditional Chinese exercises on nonspecific low back pain: a meta-analysis. J. Back Musculoskelet. Rehabil. 39, 10538127261430790 (2026).

[37]

Yang D, Huang H, Xu DD, Zhao Y. Effects of Baduanjin exercise on patients with chronic nonspecific low back pain and surface electromyography signs of erector spinal muscle: a randomized controlled trial. Med. (Baltim.), 2023, 102: e35590

[38]

Zhang Y, et al.. The beneficial effects of traditional chinese exercises for adults with low back pain: a meta-analysis of randomized controlled trials. Medicina, 2019, 55: 118

[39]

Zhai J, Liu AF, Yu W, Guo T. Baduanjin exercise for chronic non-specific low back pain: protocol for a series of N-of-1 trials. BMJ Open, 2023, 13: e070703

[40]

Li X, et al.. Effect of Tai Chi on the pain intensity or disability of patients with chronic low back pain: a systematic review and meta-analysis. Front. Sports Act. living, 2026, 8: 1676045

[41]

Qaseem A, Wilt TJ, McLean RM, Forciea MA, Amer Coll P. Noninvasive treatments for acute, subacute, and chronic low back pain: a clinical practice guideline from the american college of physicians. Ann. Intern. Med., 2017, 166: 514-U142

[42]

Chou R, et al.. Nonpharmacologic therapies for low back pain: a systematic review for an american college of physicians clinical practice guideline. Ann. Intern. Med., 2017, 166: 493

[43]

Anheyer D, Haller H, Lauche R, Dobos G, Cramer H. Yoga for treating low back pain: a systematic review and meta-analysis. Pain, 2022, 163: E504-E517

[44]

Iosub ME, Tirla S, Lazar L. Impact of Vojta therapy combined with standard care on psychometric and functional parameters in patients with chronic lower back pain: a randomized controlled trial. J. Med. Life, 2024, 17: 478-485

[45]

Saki F, Ziya M. Effects of integrating Feldenkrais method with dynamic neuromuscular stabilization exercises on clinical outcomes in older women with nonspecific chronic low back pain: a randomized controlled trial. BMC Geriatr, 2025, 25: 573

[46]

Er G, Yuksel I. A comparison of the effects of connective tissue massage and classical massage on chronic mechanical low back pain. Medicine, 2023, 102: e33516

[47]

Dal C, Koç M, Bayar B. The effects of connective tissue massage and classical massage on pain, lumbar mobility, function, disability, and well-being in chronic low back pain: A three-arm randomized controlled trial. Explore, 2024, 20: 103029

[48]

Rubinstein SM, et al.. Benefits and harms of spinal manipulative therapy for the treatment of chronic low back pain: systematic review and meta-analysis of randomised controlled trials. BMJ, 2019, 364: l689

[49]

Paige NM, et al.. Association of spinal manipulative therapy with clinical benefit and harm for acute low back pain: systematic review and meta-analysis. JAMA, 2017, 317: 1451-1460

[50]

Pangarkar SS, et al.. VA/DoD clinical practice guideline: diagnosis and treatment of low back pain. J. Gen. Intern. Med., 2019, 34: 2620-2629

[51]

Villalta Santos L, et al.. Active visceral manipulation associated with conventional physiotherapy in people with chronic low back pain and visceral dysfunction: a preliminary, randomized, controlled, double-blind clinical trial. J. Chiropr. Med, 2019, 18: 79-89

[52]

Chen ZY, Wu JL, Wang XD, Wu JQ, Ren ZB. The effects of myofascial release technique for patients with low back pain: a systematic review and meta-analysis. Complement Ther. Med., 2021, 59: 9

[53]

Wu ZG, et al.. Myofascial release for chronic low back pain: a systematic review and meta-analysis. Front. Med., 2021, 8: 14

[54]

Ozóg P, Weber-Rajek M, Radziminska A. Effects of isolated myofascial release therapy in patients with chronic low back pain-a systematic review. J. Clin. Med, 2023, 12: 11

[55]

Yang J, et al.. Efficacy and safety of Tuina for chronic nonspecific low back pain: A PRISMA-compliant systematic review and meta-analysis. Medicine, 2023, 102: e33018

[56]

Ma Q, et al.. Tuina versus physiotherapy or a combination of both for the management of chronic nonspecific low back pain: a randomized controlled trial. Complement Ther. Med., 2024, 86: 103098

[57]

Yang J, et al.. Effects of Tuina in patients with chronic nonspecific low back pain: a randomized controlled trial. J. Prim. Care Community Health, 2025, 16: 21501319251357404

[58]

Gul S, Bashir S, Kayani NM, Sabir Z, Qurat-Ul-Ain H. Effects of instrument assisted soft tissue mobilisation in patients with chronic mechanical low back pain-A randomized control trial. J. Pak. Med. Assoc, 2025, 75: 181-185

[59]

Yildirim A, Ozyilmaz S, Aksoy A, Hosbay Z. The effect of instrument-assisted soft tissue mobilization in lumbar disc herniation: A randomized controlled trial. J. Bodyw. Mov. Ther, 2024, 40: 424-429

[60]

FQ C, et al.. Efficacy and safety of moxibustion for chronic low back pain: A systematic review and meta-analysis of randomized controlled trials. Complement. Ther. Clin. Pract., 2020, 39: 101130

[61]

Yao Y, et al.. The effect and safety of thunder-fire moxibustion for low back pain: a meta-analysis of randomized controlled trials. Evid. Based Complement. Altern. Med., 2022, 2022: 6114417

[62]

Cherkin DC, et al.. A randomized trial comparing acupuncture, simulated acupuncture, and usual care for chronic low back pain. Arch. Intern. Med., 2009, 169: 858-866

[63]

Rizzo RR, et al.. Non-pharmacological and non-surgical treatments for low back pain in adults: an overview of Cochrane reviews. Cochrane Database Syst. Rev, 2025, 3: Cd014691

[64]

Liu L, et al.. Evidence for Dry Needling In The Management Of Myofascial Trigger Points Associated With Low Back Pain: A Systematic Review And Meta-analysis. Arch. Phys. Med. Rehabil., 2018, 99: 144-152

[65]

Lara-Palomo IC, et al.. Efficacy of dry needling for chronic low back pain: a systematic review and meta-analysis of randomized controlled trials. Altern. Ther. Health Med., 2023, 29: 110-120

[66]

Verville L, et al.. Systematic Review to Inform a World Health Organization (WHO) clinical practice guideline: benefits and harms of transcutaneous electrical nerve stimulation (TENS) for chronic primary low back pain in adults. J. Occup. Rehabil, 2023, 33: 651-660

[67]

Khadilkar, A. et al. Transcutaneous electrical nerve stimulation (TENS) for chronic low-back pain. Cochrane Database Syst. Rev. 3, CD003008 (2005).

[68]

Buchmuller A, et al.. Value of TENS for relief of chronic low back pain with or without radicular pain. Eur. J. Pain., 2011, 16: 656-665

[69]

Luedtke K, et al.. Effectiveness of transcranial direct current stimulation preceding cognitive behavioural management for chronic low back pain: sham controlled double blinded randomised controlled trial. Bmj, 2015, 350: h1640

[70]

Alwardat M, et al.. Is transcranial direct current stimulation (tDCS) effective for chronic low back pain? A systematic review and meta-analysis. J. Neural Transm., 2020, 127: 1257-1270

[71]

Armbrust D, et al.. Effects of osteopathic manipulative treatment associated with transcranial direct current stimulation in individuals with chronic low back pain: A double-blind, randomised placebo-controlled trial. Clin. Rehabil., 2024, 38: 1609-1621

[72]

Gilmore CA, et al.. Durable patient-reported outcomes following 60-day percutaneous peripheral nerve stimulation (PNS) of the medial branch nerves. Inter. Pain. Med., 2023, 2: 100243

[73]

Urits I, et al.. Platelet-rich plasma for the treatment of low back pain: a comprehensive review. Curr. Pain. Headache Rep., 2019, 23 52

[74]

Serio MA, et al.. Clinical efficacy and risks of intradiscal orthobiological injections: a narrative review. Curr. Pain. Headache Rep., 2025, 29 99

[75]

Sanapati J, et al.. Do regenerative medicine therapies provide long-term relief in chronic low back pain: a systematic review and metaanalysis. Pain. Physician, 2018, 21: 515-540

[76]

Pers YM, et al.. Allogenic bone marrow-derived mesenchymal stromal cell-based therapy for patients with chronic low back pain: a prospective, multicentre, randomised placebo controlled trial (RESPINE study). Ann. Rheum. Dis., 2024, 83: 1572-1583

[77]

Maal AB, et al.. Intradiscal injection of allogeneic bone marrow derived clonal mesenchymal stromal cells in discogenic low back pain: a phase I study on safety and feasibility (RELIEF: phase I). Stem Cell Res. Ther, 2025, 16: 525

[78]

van der Gaag WH, Roelofs PD, Enthoven WT, van Tulder MW, Koes BW. Non-steroidal anti-inflammatory drugs for acute low back pain. Cochrane Database Syst. Rev., 2020, 4: CD013581

[79]

Fukase H, et al.. Investigation of the effects of a new transdermal formulation of systemic diclofenac on the upper gastrointestinal mucosa in patients with low back pain: a comparative study with oral diclofenac. J. Gastroenterol. Hepatol, 2024, 39: 2504-2510

[80]

Cao Z, et al.. Paracetamol combination therapy for back pain and osteoarthritis: a systematic review and meta-analyses. Drugs, 2024, 84: 953-967

[81]

CMP J, et al.. Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial. Lancet, 2023, 402: 304-312

[82]

BW F, et al.. Naproxen with cyclobenzaprine, oxycodone/acetaminophen, or placebo for treating acute low back pain: a randomized clinical trial. JAMA, 2015, 314: 1572-1580

[83]

Friedman BW, et al.. A randomized, placebo-controlled trial of ibuprofen plus Metaxalone, Tizanidine, or Baclofen for acute low back pain. Ann. Emerg. Med., 2019, 74: 512-520

[84]

Ferraro MC, et al.. Antidepressants for low back pain and spine-related leg pain. Cochrane Database Syst. Rev., 2025, 3: CD001703

[85]

Dakin P, et al.. Efficacy and safety of fasinumab in patients with chronic low back pain: a phase II/III randomised clinical trial. Ann. Rheum. Dis., 2021, 80: 509-517

[86]

de Oliveira LA, et al.. Effects of prehabilitation on outcomes following elective lumbar spine surgery: a systematic review and meta-analysis. Br. J. pain., 2025, 19: 257-273

[87]

Muduli S, et al.. Homeopathic treatment of chronic low-back pain: a double-blind, randomized, placebo-controlled trial. J. Integr. Complement. Med, 2025, 31: 1572-1580

[88]

Ter Meulen BC, et al.. Effect of transforaminal epidural corticosteroid injections in acute sciatica: a randomized controlled trial. Clin. J. Pain., 2023, 39: 654-662

[89]

Ter Meulen BC, et al.. Cost-effectiveness of transforaminal epidural steroid injections for patients with ACUTE sciatica: a randomized controlled trial. BMC Musculoskelet. Disord., 2024, 25 247

[90]

Li H, et al.. Comparative efficacy of radiofrequency denervation in chronic low back pain: A systematic review and network meta-analysis. Front. Surg., 2022, 9: 899538

[91]

Janapala RN, et al.. Systematic review and meta-analysis of effectiveness of therapeutic sacroiliac joint injections. Pain. Physician, 2023, 26: E413-E435

[92]

Yanuck J, Saadat S, Lee JB, Jen M, Chakravarthy B. Pragmatic randomized controlled pilot trial on trigger point injections with 1% lidocaine versus conventional approaches for myofascial pain in the emergency department. J. Emerg. Med, 2020, 59: 364-370

[93]

C, et al. Intradiscal glucocorticoid injection for patients with chronic low back pain associated with active discopathy: a randomized trial. Ann. Internal Med. 166, 547–556 (2017).

[94]

Riegger M, et al.. Intradiscal glucocorticoid injection in discogenic back pain and influence on modic changes: a systematic review and meta-analysis of RCTs. Pain. Physician, 2023, 26: E449-E465

[95]

Llombart-Blanco R, et al.. The effectiveness of ozone infiltration on patient-reported outcomes in low back pain: a systematic review and meta-analysis. Life, 2024, 14: 1406

[96]

Rimeika G, et al.. Metanalysis on the effectiveness of low back pain treatment with oxygen-ozone mixture: comparison between image-guided and non-image-guided injection techniques. Eur. J. Radiol. Open, 2021, 8: 100389

[97]

Kvarstein G, et al.. A randomized double-blind controlled trial of intra-annular radiofrequency thermal disc therapy – a 12-month follow-up. Pain, 2009, 145: 279-286

[98]

Liu L, Peng B, Guo Y, Luo J. Efficacy of radiofrequency ablation in the treatment of discogenic low back pain: a meta-analysis. J. Orthop. Surg. Res, 2025, 20: 1054

[99]

Helm Ii S, Simopoulos TT, Stojanovic M, Abdi S, El Terany MA. Effectiveness of thermal annular procedures in treating discogenic low back pain. Pain. Physician, 2017, 20: 447-470

[100]

Nikoobakht M, Yekanineajd MS, Pakpour AH, Gerszten PC, Kasch R. Plasma disc decompression compared to physiotherapy for symptomatic contained lumbar disc herniation: a prospective randomized controlled trial. Neurol. Neurochir. Pol., 2016, 50: 24-30

[101]

Kapural L, et al.. Treatment of nonsurgical refractory back pain with high-frequency spinal cord stimulation at 10 kHz: 12-month results of a pragmatic, multicenter, randomized controlled trial. J. Neurosurg. Spine, 2022, 37: 188-199

[102]

Patel NP, et al.. Durable responses at 24 months with high-frequency spinal cord stimulation for nonsurgical refractory back pain. J. Neurosurg. Spine, 2024, 40: 229-239

[103]

Park S, et al.. Pulsed radiofrequency of lumbar dorsal root ganglion for lumbar radicular pain: a systematic review and meta-analysis. Pain. Pract., 2024, 24: 772-785

[104]

Pastrak M, Visnjevac O, Visnjevac T, Ma F, Abd-Elsayed A. Safety of conventional and pulsed radiofrequency lesions of the dorsal root entry zone complex (DREZC) for interventional pain management: a systematic review. Pain. Ther., 2022, 11: 411-445

[105]

Campos-Fajardo S, Sierra-Peña JA, Suárez-Monsalve S, Acevedo-González JC. Effectiveness of dorsal root ganglion stimulation in chronic pain management: a systematic review. World Neurosurg, 2024, 190: 157-171

[106]

D’Souza RS, et al.. Dorsal root ganglion stimulation for lower extremity neuropathic pain syndromes: an evidence-based literature review. Adv. Ther., 2022, 39: 4440-4473

[107]

D’Souza RS, Jin MY, Abd-Elsayed A. Peripheral nerve stimulation for low back pain: a systematic review. Curr. Pain. Headache Rep., 2023, 27: 117-128

[108]

Eldabe SS, et al.. A randomized controlled trial of subcutaneous nerve stimulation for back pain due to failed back surgery syndrome: the SubQStim Study. Neuromodulation, 2019, 22: 519-528

[109]

Gadjradj PS, et al.. Full endoscopic versus open discectomy for sciatica: randomised controlled non-inferiority trial. BMJ, 2022, 376: e065846

[110]

Patel T, et al.. Comparative effectiveness of minimally invasive endoscopic discectomy versus conventional surgical techniques for lumbar disc herniation: a systematic review and meta-analysis. Ann. Med. Surg, 2025, 87: 6661-6674

[111]

Daher M, Nassar J, Balmaceno-Criss M, Diebo BG, Daniels AH. Lumbar disc replacement versus interbody fusion: meta-analysis of complications and clinical outcomes. Orthop. Rev., 2024, 16: 116900

[112]

Wen DJ, Tavakoli J, Tipper JL. Lumbar total disc replacements for degenerative disc disease: a systematic review of outcomes with a minimum of 5 years follow-up. Glob. Spine J., 2024, 14: 1827-1837

[113]

Ma XL, et al.. Effectiveness of surgery versus conservative treatment for lumbar spinal stenosis: a system review and meta-analysis of randomized controlled trials. Int J. Surg., 2017, 44: 329-338

[114]

Kgomotso EL, et al.. Decompression alone or with fusion for degenerative lumbar spondylolisthesis (Nordsten-DS): five year follow-up of a randomised, multicentre, non-inferiority trial. BMJ, 2024, 386: e079771

[115]

Phillips FM, Slosar PJ, Youssef JA, Andersson G, Papatheofanis F. Lumbar spine fusion for chronic low back pain due to degenerative disc disease: a systematic review. Spine, 2013, 38: E409-E422

[116]

Austevoll IM, et al.. Decompression with or without Fusion in Degenerative Lumbar Spondylolisthesis. N. Engl. J. Med, 2021, 385: 526-538

[117]

Polly DW, et al.. Randomized controlled trial of minimally invasive sacroiliac joint fusion using triangular titanium implants vs nonsurgical management for sacroiliac joint dysfunction: 12-month outcomes. Neurosurgery, 2015, 77: 674-690

[118]

Hermans SMM, et al.. Minimally invasive sacroiliac joint fusion vs conservative management in patients with sacroiliac joint dysfunction: a systematic review and meta-analysis. Int. J. spine Surg., 2022, 16: 472-480

[119]

Kamper SJ, et al.. Multidisciplinary biopsychosocial rehabilitation for chronic low back pain: cochrane systematic review and meta-analysis. Bmj, 2015, 350: h444

[120]

In WHO guideline for non-surgical management of chronic primary low back pain in adults in primary and community care settings (World Health Organization, 2023).

[121]

Pocovi NC, et al.. Effectiveness and cost-effectiveness of an individualised, progressive walking and education intervention for the prevention of low back pain recurrence in Australia (WalkBack): a randomised controlled trial. Lancet, 2024, 404: 134-144

[122]

Traeger AC, et al.. Effect of primary care-based education on reassurance in patients with acute low back pain: systematic review and meta-analysis. JAMA Intern. Med., 2015, 175: 733-743

[123]

Ho EK, et al.. Psychological interventions for chronic, non-specific low back pain: systematic review with network meta-analysis. Bmj, 2022, 376: e067718

[124]

Hall A, et al.. Physiotherapist-delivered cognitive-behavioural interventions are effective for low back pain, but can they be replicated in clinical practice? A systematic review. Disabil. Rehabil., 2018, 40: 1-9

[125]

O’Keeffe M, O’Sullivan P, Purtill H, Bargary N, O’Sullivan K. Cognitive functional therapy compared with a group-based exercise and education intervention for chronic low back pain: a multicentre randomised controlled trial (RCT). Br. J. Sports Med., 2020, 54: 782-789

[126]

de Campos TF. Low back pain and sciatica in over 16s: assessment and management NICE Guideline [NG59]. J. Physiother, 2017, 63: 120-120

[127]

Hill JC, et al.. Comparison of stratified primary care management for low back pain with current best practice (STarT Back): a randomised controlled trial. Lancet, 2011, 378: 1560-1571

[128]

Stacey, D. et al. Decision aids for people facing health treatment or screening decisions. Cochrane Database Syst. Rev. 4, CD001431 (2017).

[129]

Whitehurst DG, Bryan S, Lewis M, Hill J, Hay EM. Exploring the cost-utility of stratified primary care management for low back pain compared with current best practice within risk-defined subgroups. Ann. Rheum. Dis., 2012, 71: 1796-1802

[130]

Straube S, et al.. Back schools for the treatment of chronic low back pain: possibility of benefit but no convincing evidence after 47 years of research-systematic review and meta-analysis. Pain, 2016, 157: 2160-2172

[131]

Hernandez-Lucas P, Leirós-Rodríguez R, Lopez-Barreiro J, García-Soidán JL. The effects of back schools on non-specific back pain: a systematic review and meta-analysis. J. Pers. Med, 2024, 14: 272

[132]

Nicholl BI, et al.. Digital support interventions for the self-management of low back pain: a systematic review. J. Med. Internet Res., 2017, 19: e179

[133]

Geraghty AWA, et al.. Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2). Health Technol. Assess., 2025, 29: 1-90

[134]

Koppenaal T, et al.. The 3-month effectiveness of a stratified blended physiotherapy intervention in patients with nonspecific low back pain: cluster randomized controlled trial. J. Med. Internet Res., 2022, 24: e31675

[135]

Geraghty AWA, et al.. Supporting self-management of low back pain with an internet intervention with and without telephone support in primary care (SupportBack 2): a randomised controlled trial of clinical and cost-effectiveness. Lancet Rheumatol, 2024, 6: e424-e437

[136]

Russo F, et al.. The effects of workplace interventions on low back pain in workers: a systematic review and meta-analysis. Int. J. Environ Res. Public Health, 2021, 18: 12614

[137]

Cullen KL, et al.. Effectiveness of workplace interventions in return-to-work for musculoskeletal, pain-related and mental health conditions: an update of the evidence and messages for practitioners. J. Occup. Rehabil, 2018, 28: 1-15

[138]

Xiao C, et al.. Clinical efficacy of multimodal exercise telerehabilitation based on ai for chronic nonspecific low back pain: randomized controlled trial. JMIR mHealth uHealth, 2025, 13: e56176

[139]

Marcuzzi A, et al.. Effect of an artificial intelligence-based self-management app on musculoskeletal health in patients with neck and/or low back pain referred to specialist care: a randomized clinical trial. JAMA Netw. Open, 2023, 6: e2320400

[140]

Eboreime KO, Hughes JG, Lee R, Luo J. Can wearable device promote physical activity and reduce pain in people with chronic musculoskeletal conditions?. J. Clin. Med, 2025, 14: 1003

[141]

Ferguson T, et al.. Effectiveness of wearable activity trackers to increase physical activity and improve health: a systematic review of systematic reviews and meta-analyses. Lancet Digit Health, 2022, 4: e615-e626

[142]

Hurri H, Karppinen J. Discogenic pain. Pain, 2004, 112: 225-228

[143]

Borenstein DG, et al.. The value of magnetic resonance imaging of the lumbar spine to predict low-back pain in asymptomatic subjects: a seven-year follow-up study. JBJS, 2001, 83: 1306-1311

[144]

Maher C, Underwood M, Buchbinder R. Non-specific low back pain. Lancet, 2017, 389: 736-747

[145]

Hartvigsen J, et al.. What low back pain is and why we need to pay attention. Lancet, 2018, 391: 2356-2367

[146]

Zheng L, et al.. Ciliary parathyroid hormone signaling activates transforming growth factor-β to maintain intervertebral disc homeostasis during aging. Bone Res, 2018, 6: 21

[147]

Bian Q, et al.. Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis. Bone Res, 2017, 5: 17008

[148]

Watanabe T, Otani K, Sekiguchi M, Konno S. -i Relationship between lumbar disc degeneration on MRI and low back pain: a cross-sectional community study. Fukushima J. Med. Sci., 2022, 68: 97-107

[149]

Ni S, et al.. Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice. Nat. Commun., 2019, 10 5643

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National Science Foundation of China | Key Programme(82430077)

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