Structure and function of the membrane microdomains in osteoclasts

Abstract

The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases. Strong experimental evidence supports the existence of membrane microdomains in osteoclasts (OCs). However, the potential membrane microdomains and the crucial mechanisms underlying their roles in OCs have not been fully characterized. Membrane microdomain components, such as scaffolding proteins and the actin cytoskeleton, as well as the roles of individual membrane proteins, need to be elucidated. In this review, we discuss the compositions and critical functions of membrane microdomains that determine the biological behavior of OCs through the three main stages of the OC life cycle.

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Funding

the National Nature Science Fund of China(grant no.82102313) Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project (grant No.2023ZL497) Zhejiang Province Medical and Health Science and Technology Project(grant No.2022519563).

National Health and Medical Research Council of Australia (grant No.app1107828, app1163933)