Progress in osteoarthritis research by the National Natural Science Foundation of China

Yusheng Li , Wenqing Xie , Wenfeng Xiao , Dou Dou

Bone Research ›› 2022, Vol. 10 ›› Issue (1) : 41

PDF
Bone Research ›› 2022, Vol. 10 ›› Issue (1) : 41 DOI: 10.1038/s41413-022-00207-y
Review Article

Progress in osteoarthritis research by the National Natural Science Foundation of China

Author information +
History +
PDF

Abstract

Osteoarthritis (OA) in China is gradually becoming an important scientific research area that has had a significant impact on research and development (R&D) activities in the OA field worldwide. This article summarizes the R&D progress related to OA in China in recent years. The National Natural Science Foundation of China (NSFC) is a national funding institution for basic research and plays a critical role in promoting and supporting Chinese scholars’ R&D activities. We collected and analyzed information on NSFC funding in the field of OA from 2010 to 2019, including the amount, the level and the program categories of the funded projects. The data fully demonstrate the important and positive role of the NSFC in supporting free exploration, cultivating research teams and young talent, and boosting OA R&D. In this article, we outline and discuss hot topics in focused areas, key advances in this field and the prospects for progress in OA research in China.

Cite this article

Download citation ▾
Yusheng Li, Wenqing Xie, Wenfeng Xiao, Dou Dou. Progress in osteoarthritis research by the National Natural Science Foundation of China. Bone Research, 2022, 10(1): 41 DOI:10.1038/s41413-022-00207-y

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Glyn-Jones S et al. Osteoarthritis. Lancet, 2015, 386: 376-387

[2]

Jevsevar DS et al. The American Academy of Orthopaedic Surgeons evidence-based guideline on: treatment of osteoarthritis of the knee, 2nd edition. J. Bone Jt. Surg. Am., 2013, 95: 1885-1886

[3]

Pereira D et al. The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. Osteoarthr. Cartil., 2011, 19: 1270-1285

[4]

Safiri S et al. Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017. Ann. Rheum. Dis., 2020, 79: 819-828

[5]

Turkiewicz A et al. Current and future impact of osteoarthritis on health care: a population-based study with projections to year 2032. Osteoarthr. Cartil., 2014, 22: 1826-1832

[6]

Environment, N. I. f. P. H. a. t. Public Health Foresight Study 2018 (VTV-2018): diseases, https://www.vtv2018.nl/en/diseases (accessed April 7, 2019) (2018).

[7]

Prieto-Alhambra D et al. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann. Rheum. Dis., 2014, 73: 1659-1664

[8]

Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin. Geriatr. Med, 2010, 26: 355-369

[9]

Farooqi A, Gibson T. Prevalence of the major rheumatic disorders in the adult population of north Pakistan. Br. J. Rheumatol., 1998, 37: 491-495

[10]

Pountain G. Musculoskeletal pain in Omanis, and the relationship to joint mobility and body mass index. Br. J. Rheumatol., 1992, 31: 81-85

[11]

Tehrani-Banihashemi A et al. Prevalence of osteoarthritis in rural areas of Iran: a WHO-ILAR COPCORD study. Int J. Rheum. Dis., 2014, 17: 384-388

[12]

Zhang W, Ouyang H, Dass CR, Xu J. Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone Res., 2016, 4: 15040

[13]

Tie X et al. Prevalence of knee osteoarthritis in the middle-aged and elderly in China: a Meta-analysis. Chin. J. Tissue Eng. Res., 2018, 22: 650-656

[14]

Sun, X. et al. Osteoarthritis in the middle-aged and elderly in China: Prevalence and influencing factors. Int. J. Environ. Res. Public Health 16, 4701 (2019).

[15]

Zhang Y et al. Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study. Arthritis Rheum., 2001, 44: 2065-2071

[16]

Nevitt MC et al. Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study. Arthritis Rheum., 2002, 46: 1773-1779

[17]

Zhang Y et al. Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: the Beijing Osteoarthritis Study. Arthritis Rheum., 2003, 48: 1034-1040

[18]

Kang X et al. The high prevalence of knee osteoarthritis in a rural Chinese population: the Wuchuan osteoarthritis study. Arthritis Rheum., 2009, 61: 641-647

[19]

Chen D et al. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res., 2017, 5: 16044

[20]

Felson DT. Clinical practice. Osteoarthritis of the knee. N. Engl. J. Med., 2006, 354: 841-848

[21]

Hunter DJ, Schofield D, Callander E. The individual and socioeconomic impact of osteoarthritis. Nat. Rev. Rheumatol., 2014, 10: 437-441

[22]

Cheng C, Gao S, Lei G. Association of osteopontin with osteoarthritis. Rheumatol. Int, 2014, 34: 1627-1631

[23]

Chen Y et al. Macrophages in osteoarthritis: pathophysiology and therapeutics. Am. J. Transl. Res., 2020, 12: 261-268

[24]

Deng ZH et al. Topical diclofenac therapy for osteoarthritis: a meta-analysis of randomized controlled trials. Clin. Rheumatol., 2016, 35: 1253-1261

[25]

Zeng C et al. Association of Tramadol with all-cause mortality among patients with Osteoarthritis. JAMA, 2019, 321: 969-982

[26]

Hunter DJ. Viscosupplementation for osteoarthritis of the knee. N. Engl. J. Med., 2015, 372: 1040-1047

[27]

Jiang W, Wang H, Li YS, Luo W. Role of vasoactive intestinal peptide in osteoarthritis. J. Biomed. Sci., 2016, 23: 63

[28]

Wilkie R, Peat G, Thomas E, Croft P. Factors associated with restricted mobility outside the home in community-dwelling adults ages fifty years and older with knee pain: an example of use of the International Classification of Functioning to investigate participation restriction. Arthritis Rheum., 2007, 57: 1381-1389

[29]

Hawker GA. Experiencing painful osteoarthritis: what have we learned from listening? Curr. Opin. Rheumatol., 2009, 21: 507-512

[30]

Hawker GA et al. The multidimensionality of sleep quality and its relationship to fatigue in older adults with painful osteoarthritis. Osteoarthr. Cartil., 2010, 18: 1365-1371

[31]

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392, 1859–1922, (2018).

[32]

Murray CJ et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, 380: 2197-2223

[33]

Guccione AA et al. The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am. J. Public Health, 1994, 84: 351-358

[34]

Wang Y et al. Knee osteoarthritis, potential mediators, and risk of all-cause mortality: data from the osteoarthritis initiative. Arthritis Care Res. (Hoboken), 2021, 73: 566-573

[35]

March LM, Bachmeier CJ. Economics of osteoarthritis: a global perspective. Baillieres Clin. Rheumatol., 1997, 11: 817-834

[36]

Kotlarz H, Gunnarsson CL, Fang H, Rizzo JA. Insurer and out-of-pocket costs of osteoarthritis in the US: evidence from national survey data. Arthritis Rheum., 2009, 60: 3546-3553

[37]

Gupta S, Hawker GA, Laporte A, Croxford R, Coyte PC. The economic burden of disabling hip and knee osteoarthritis (OA) from the perspective of individuals living with this condition. Rheumatology, 2005, 44: 1531-1537

[38]

Salmon JH et al. Economic impact of lower-limb osteoarthritis worldwide: a systematic review of cost-of-illness studies. Osteoarthr. Cartil., 2016, 24: 1500-1508

[39]

Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J. Bone Jt. Surg. Am., 2007, 89: 780-785

[40]

Woo J et al. Socioeconomic impact of osteoarthritis in Hong Kong: utilization of health and social services, and direct and indirect costs. Arthritis Rheum., 2003, 49: 526-534

[41]

Chen H et al. The contributions of diseases to disability burden among the elderly population in China. J. Aging Health, 2014, 26: 261-282

[42]

Liu Q, Wang S, Lin J, Zhang Y. The burden for knee osteoarthritis among Chinese elderly: estimates from a nationally representative study. Osteoarthr. Cartil., 2018, 26: 1636-1642

[43]

Long H et al. Burden of osteoarthritis in China, 1990–2017: findings from the Global Burden of Disease Study 2017. Lancet Rheumatol., 2020, 2: e164-e172

[44]

Bozic KJ, Ward L, Vail TP, Maze M. Bundled payments in total joint arthroplasty: targeting opportunities for quality improvement and cost reduction. Clin. Orthop. Relat. Res., 2014, 472: 188-193

[45]

Lavernia C, Lee DJ, Hernandez VH. The increasing financial burden of knee revision surgery in the United States. Clin. Orthop. Relat. Res., 2006, 446: 221-226

[46]

Patel A, Pavlou G, Mújica-Mota RE, Toms AD. The epidemiology of revision total knee and hip arthroplasty in England and Wales: a comparative analysis with projections for the United States. A study using the National Joint Registry dataset. Bone Jt. J., 2015, 97-b: 1076-1081

[47]

Nemes S, Gordon M, Rogmark C, Rolfson O. Projections of total hip replacement in Sweden from 2013 to 2030. Acta Orthop., 2014, 85: 238-243

[48]

Bian Y, Cheng K, Chang X, Weng X. Reports and analysis of amount of hip and knee arthroplasty in China from 2011 to 2019. Chin. J. Orthop., 2020, 40: 1453-1460

[49]

Kotlarz H, Gunnarsson CL, Fang H, Rizzo JA. Osteoarthritis and absenteeism costs: evidence from US National Survey Data. J. Occup. Environ. Med, 2010, 52: 263-268

[50]

Schofield DJ et al. The personal and national costs of lost labour force participation due to arthritis: an economic study. BMC Public Health, 2013, 13

[51]

China, N. B. o. S. o. China statistical yearbook 2020. (China Statistics Press, 2020). http://www.stats.gov.cn/tjsj/ndsj/2020/indexeh.htm.

[52]

Cao Y et al. Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review. Rheumatology, 2013, 52: 1323-1334

[53]

Zhang HX, Wang YG, Lu SY, Lu XX, Liu J. Identification of IL-7 as a candidate disease mediator in osteoarthritis in Chinese Han population: a case-control study. Rheumatology, 2016, 55: 1681-1685

[54]

Huang MJ et al. Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice. Ann. Rheum. Dis., 2014, 73: 1719-1727

[55]

Lin C et al. Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12. Bone Res., 2019, 7: 5

[56]

Li K et al. Tyrosine kinase Fyn promotes osteoarthritis by activating the beta-catenin pathway. Ann. Rheum. Dis., 2018, 77: 935-943

[57]

Zhang H et al. Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2. Ann. Rheum. Dis., 2018, 77: 1524-1534

[58]

Weng T et al. Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice. Arthritis Rheum., 2012, 64: 3982-3992

[59]

Tang J et al. Fibroblast growth factor Receptor 3 inhibits osteoarthritis progression in the knee joints of adult mice. Arthritis Rheumatol., 2016, 68: 2432-2443

[60]

Zhu S et al. Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo. Ann. Rheum. Dis., 2015, 74: 285-293

[61]

Zhu S et al. Down-regulation of Rac GTPase-activating protein OCRL1 causes aberrant activation of Rac1 in osteoarthritis development. Arthritis Rheumatol., 2015, 67: 2154-2163

[62]

Dai J et al. Kdm6b regulates cartilage development and homeostasis through anabolic metabolism. Ann. Rheum. Dis., 2017, 76: 1295-1303

[63]

Zhu X et al. PPARgamma preservation via promoter demethylation alleviates osteoarthritis in mice. Ann. Rheum. Dis., 2019, 78: 1420-1429

[64]

Lian C et al. Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin beta1-SMAD1 interaction. Bone Res., 2019, 7: 8

[65]

Deng Y et al. Reciprocal inhibition of YAP/TAZ and NF-kappaB regulates osteoarthritic cartilage degradation. Nat. Commun., 2018, 9

[66]

Ji Q et al. Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis. Nat. Commun., 2019, 10

[67]

Ji Q et al. Single-cell RNA-seq analysis reveals the progression of human osteoarthritis. Ann. Rheum. Dis., 2019, 78: 100-110

[68]

Xie J, Zhang D, Lin Y, Yuan Q, Zhou X. Anterior cruciate ligament transection-induced cellular and extracellular events in menisci: implications for osteoarthritis. Am. J. Sports Med., 2018, 46: 1185-1198

[69]

Shen S et al. CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene. Ann. Rheum. Dis., 2019, 78: 826-836

[70]

Xu H et al. Utilization of longitudinal ultrasound to quantify joint soft-tissue changes in a mouse model of posttraumatic osteoarthritis. Bone Res., 2017, 5: 17012

[71]

Shi Y et al. A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development. Nat. Commun., 2019, 10

[72]

Liu Q et al. Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis. Arthritis Rheumatol., 2014, 66: 969-978

[73]

Dai L et al. Silencing of miR-101 prevents cartilage degradation by regulating extracellular matrix-related genes in a rat model of osteoarthritis. Mol. Ther., 2015, 23: 1331-1340

[74]

Liu Q et al. The TMSB4 Pseudogene LncRNA functions as a competing endogenous RNA to promote cartilage degradation in human osteoarthritis. Mol. Ther., 2016, 24: 1726-1733

[75]

Deng C et al. Bioactive scaffolds for regeneration of cartilage and subchondral bone interface. Theranostics, 2018, 8: 1940-1955

[76]

Li H, Xue K, Kong N, Liu K, Chang J. Silicate bioceramics enhanced vascularization and osteogenesis through stimulating interactions between endothelia cells and bone marrow stromal cells. Biomaterials, 2014, 35: 3803-3818

[77]

Chen P et al. Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing. Biomaterials, 2015, 39: 114-123

[78]

Wu Y et al. A Bi-lineage conducive scaffold for osteochondral defect regeneration. Adv. Funct. Mater., 2014, 24: 4473-4483

[79]

Wu J et al. miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis. Biomaterials, 2019, 206: 87-100

[80]

Zhou C et al. Runt-related transcription factor-1 (Runx1) protects against the pathological progression of osteoarthritis. Bone Res., 2021, 9: 50

[81]

Chu CR, Andriacchi TP. Dance between biology, mechanics, and structure: A systems-based approach to developing osteoarthritis prevention strategies. J. Orthop. Res., 2015, 33: 939-947

[82]

Kim JE, Song DH, Kim SH, Jung Y, Kim SJ. Development and characterization of various osteoarthritis models for tissue engineering. PloS One, 2018, 13: e0194288

[83]

Sun AR et al. Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis. PLoS One, 2017, 12: e0183693

[84]

Lawson TB, Mäkelä JTA, Klein T, Snyder BD, Grinstaff MW. Nanotechnology and osteoarthritis; part 1: Clinical landscape and opportunities for advanced diagnostics. J. Orthop. Res., 2021, 39: 465-472

[85]

Hawker GA. Osteoarthritis is a serious disease. Clin. Exp. Rheumatol., 2019, 37: 3-6

[86]

Eichaker LR, Cho H, Duvall CL, Werfel TA, Hasty KA. Future nanomedicine for the diagnosis and treatment of osteoarthritis. Nanomedicine, 2014, 9: 2203-2215

[87]

Chen L, Ye L, Liu H, Yang P, Yang B. Extracorporeal shock wave therapy for the treatment of osteoarthritis: a systematic review and meta-analysis. Biomed. Res. Int, 2020, 2020: 1907821

[88]

Sirong S et al. Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis. Bone Res, 2020, 8: 6

[89]

Xie, R. et al. Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis. Nat. Biomed. Eng., 5, 1189–1201 (2021).

[90]

Chen Z et al. DNA-grafted hyaluronic acid system with enhanced injectability and biostability for photo-controlled osteoarthritis gene therapy. Adv. Sci. (Weinh.), 2021, 8: 2004793

[91]

Yuan C et al. Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas. Bone Res., 2020, 8: 38

[92]

Murphy MP et al. Articular cartilage regeneration by activated skeletal stem cells. Nat. Med., 2020, 26: 1583-1592

[93]

Wei J et al. Association between gut microbiota and symptomatic hand osteoarthritis: data from the xiangya osteoarthritis study. Arthritis Rheumatol., 2021, 73: 1656-1662

[94]

Guan Z et al. Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice. Clin. Sci., 2020, 134: 3159-3174

[95]

Wang Z, Zhu H, Jiang Q, Zhu YZ. The gut microbiome as non-invasive biomarkers for identifying overweight people at risk for osteoarthritis. Micro. Pathog., 2021, 157: 104976

[96]

Huang Z et al. Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice. Ann. Rheum. Dis., 2020, 79: 646-656

[97]

Xia R et al. Verification and clinical translation of a newly designed “Skywalker” robot for total knee arthroplasty: A prospective clinical study. J. Orthop. Transl., 2021, 29: 143-151

[98]

Banger M et al. Robotic arm-assisted versus conventional medial unicompartmental knee arthroplasty: five-year clinical outcomes of a randomized controlled trial. Bone Jt. J., 2021, 103-b: 1088-1095

AI Summary AI Mindmap
PDF

116

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/