Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth

Abstract

Bone morphogenetic proteins (Bmp) regulate growth of different types of bone tissue via different mechanisms. Although Bmp have long been known to control formation of bone and cartilage, the exact mechanisms remain poorly understood. Fanxin Long at the Washington University School of Medicine in St. Louis, USA, and coworkers had previously shown that deleting a particular Bmp receptor causes formation of too much cancellous bone, the spongy, metabolically active tissue in the middle of bones, and not enough periosteal bone, the outermost layer. Long and coworkers investigated the role of Bmp signaling using genetically modified mice and discovered that Bmp regulates formation of the two types of bone tissue via two different mechanisms. These results improve our understanding of the signaling mechanisms that regulate bone growth.

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