Paradigm shift in wearable bioelectronics: Drift-free organic field-effect transistor biosensors enabled by diode-connected pairs

Abstract

Organic field-effect transistor (OFET)-based biosensors are promising for wearable technology due to their good flexibility and low-cost fabrication. However, their susceptibility to signal drift from mechanical stress and environmental factors like temperature has been a major limitation. In this Commentary, we highlight a novel strategy that fundamentally redesigns the OFET biosensing circuit to eliminate the drifts.

Keywords

biosensors / drift-canceling / flexible electronics / OFET

References

[1] W. Gao, S. Emaminejad, H. Y. Y. Nyein, S. Challa, K. Chen, A. Peck, H. M. Fahad, H. Ota, H. Shiraki, D. Kiriya, D.-H. Lien, G. A. Brooks, R. W. Davis, A. Javey, Nature 2016, 529, 509.

[2] Y. Wang, H. Haick, S. Guo, C. Wang, S. Lee, T. Yokota, T. Someya, Chem. Soc. Rev. 2022, 51, 3759.

[3] S. Yuvaraja, A. Nawaz, Q. Liu, D. Dubal, S. G. Surya, K. N. Salama, P. Sonar, Chem. Soc. Rev. 2020, 49, 3423.

[4] B. Park, C. Jeong, J. Ok, T.-I. Kim, Chem. Rev. 2024, 124, 6148.

[5] W. Wang, S. Wang, R. Rastak, Y. Ochiai, S. Niu, Y. Jiang, P. K. Arunachala, Y. Zheng, J. Xu, N. Matsuhisa, X. Yan, S.-K. Kwon, M. Miyakawa, Z. Zhang, R. Ning, A. M. Foudeh, Y. Yun, C. Linder, J. B. H. Tok, Z. Bao, Nat. Electron. 2021, 4, 143.

[6] S. Park, S. H. Kim, H. H. Choi, B. Kang, K. Cho, Adv. Funct. Mater. 2020, 30, 1904590.

[7] F. M. Albarghouthi, D. Semeniak, I. Khanani, J. L. Doherty, B. N. Smith, M. Salfity, Q. MacFarlane, A. Karappur, S. G. Noyce, N. X. Williams, D. Y. Joh, J. B. Andrews, A. Chilkoti, A. D. Franklin, ACS Nano 2024, 18, 5698.

[8] C. Zhao, J. Park, D. Maulà, Y. Yuan, D. Zhong, W. Wang, Q. Liu, C. Xu, Y. Zheng, R. K. Mow, Y. Jiang, C. Xu, H. Lyu, L. Michalek, A. Berman, Y. Jiang, S. Wei, C. Zhu, C. Wu, A. Abramson, E. Kim, X. Ji, Z. Yu, J. Shi, M. Khatib, B. Shi, Z. Bao, Nat. Electron. 2025, 8, 981.

Rights & permissions

2026 The Author(s). BMEMat published by John Wiley & Sons Australia, Ltd on behalf of Shandong University.