A Promising Path Forward in Obesity Pharmacotherapy: Ecnoglutide and the Evolution of GLP-1R Agonist Design

Liangbin Zhou , Pingyu Jin , Dongze Wu , Xiangdong Ye

BIO Integration ›› 2025, Vol. 6 ›› Issue (1) : 37

PDF (1533KB)
BIO Integration ›› 2025, Vol. 6 ›› Issue (1) :37 DOI: 10.15212/bioi-2025-0129
Editorial Commentary
research-article
A Promising Path Forward in Obesity Pharmacotherapy: Ecnoglutide and the Evolution of GLP-1R Agonist Design
Author information +
History +
PDF (1533KB)

Cite this article

Download citation ▾
Liangbin Zhou, Pingyu Jin, Dongze Wu, Xiangdong Ye. A Promising Path Forward in Obesity Pharmacotherapy: Ecnoglutide and the Evolution of GLP-1R Agonist Design. BIO Integration, 2025, 6 (1) : 37 DOI:10.15212/bioi-2025-0129

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Ji L, Gao L, Xue H, Tian J, Wang K, et al. Efficacy and safety of a biased GLP-1 receptor agonist ecnoglutide in adults with overweight or obesity: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol 2025; 13(9): 777-89. [PMID: 40555243 DOI: 10.1016/S2213-8587(25)00141-X]

[2]

Mu Y, Bao X, Eliaschewitz FG, Hansen MR, Kim BT, et al. Efficacy and safety of once weekly semaglutide 2.4 mg for weight management in a predominantly east Asian population with overweight or obesity (STEP 7): a double-blind, multicentre, randomised controlled trial. Lancet Diabetes Endocrinol 2024; 12(3): 184-95. [PMID: 38330988 DOI: 10.1016/S2213-8587(23)00388-1]

[3]

Zhao L, Cheng Z, Lu Y, Liu M, Chen H, et al. Tirzepatide for weight reduction in Chinese adults with obesity: the SURMOUNT-CN randomized clinical trial. JAMA 2024; 332(7): 551-60. [PMID: 38819983 DOI: 10.1001/jama.2024.9217]

[4]

Guo W, Xu Z, Zou H, Li F, Li Y, et al. Discovery of ecnoglutide - A novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog. Mol Metab 2023; 75: 101762. [PMID: 37364710 DOI: 10.1016/j.molmet.2023.101762]

[5]

Bain EK, Bain SC. Recent developments in GLP-1RA therapy: a review of the latest evidence of efficacy and safety and differences within the class. Diabetes Obes Metab 2021; 23(suppl 3): 30-9. [PMID: 34324260 DOI: 10.1111/dom.14487]

PDF (1533KB)

0

Accesses

0

Citation

Detail

Sections
Recommended

/