Application of Music Therapy in Stroke Rehabilitation: A Research Review

Abstract

This article provides a systematic review of music therapy research progress and clinical applications in stroke rehabilitation. Music therapy, through techniques such as Melodic Intonation Therapy (MIT) and Rhythmic Auditory Stimulation (RAS), offers distinct advantages by activating alternative neural pathways and promoting neuroplasticity, which significantly improves emotional regulation, cognitive function, language expression, and motor function in stroke patients. According to clinical evidence, music therapy notably decreases depression and anxiety; promotes neuroplasticity; activates brain regions associated with language and motor function; and improves gait stability and limb coordination. However, current research faces challenges such as insufficient sample sizes, unclear long-term effects, and a lack of standardized protocols. Future studies should incorporate technologies such as artificial intelligence and virtual reality to explore personalized music therapy interventions and establish multi-center collaborative clinical research systems, thereby promoting standardized application of music therapy in stroke rehabilitation.

Keywords

Cognitive function / emotional improvement / language recovery / melodic intonation therapy / motor function / music therapy / neuroplasticity / rhythmic auditory stimulation / stroke rehabilitation

References

[1] Syafni AN. Post stroke patient medical rehabilitation. J Ilm Kesehat Sandi Husada 2020; 12: 873-877. [DOI: 10.35816/jiskh.v12i2.428]

[2] Stockbridge MD, Bunker LD, Hillis AE. Reversing the ruin: rehabilitation, recovery, and restoration after stroke. Curr Neurol Neurosci Rep 2022; 22: 745-755. [PMID: 36181577 DOI: 10.1007/s11910-022-01231-5]

[3] Strzemecka J. Music therapy in stroke rehabilitation. J Pre Clin Clin Res 2013; 7: 23-26. [DOI: 10.26444/jpccr/71429]

[4] Stegemöller EL. Exploring a neuroplasticity model of music therapy. J Music Ther 2014; 51: 211-227. [PMID: 25316915 DOI: 10.1093/jmt/thu023]

[5] Thaut MH, Abiru M. Rhythmic auditory stimulation in rehabilitation of movement disorders: a review of current research. Music Percept 2010; 27: 263-269. [DOI: 10.1525/mp.2010.27.4.263]

[6] Kadivar Z, Corcos DM, Foto J, Hondzinski JM. Effect of step training and rhythmic auditory stimulation on functional performance in Parkinson patients. Neurorehabil Neural Repair 2011; 25: 626-635. [PMID: 21436393 DOI: 10.1177/1545968311401627]

[7] Dayuan Z, Lan L, Hui C, Huanjie L, Deliang L, et al. The effect of music as an intervention for post-stroke depression: a systematic review and meta-analysis. Complement Ther Med 2022; 71: 102901. [PMID: 36399968 DOI: 10.1016/j.ctim.2022.102901]

[8] Zhong K, An X, Kong Y. The effectiveness of five-element music therapy for post-stroke depression: a systematic review and meta-analysis. Heliyon 2024; 10: e26603. [PMID: 38444465 DOI: 10.1016/j.heliyon.2024.e26603]

[9] Hendry N, Lynam DS, Lafarge C. Singing for wellbeing: formulating a model for community group singing interventions. Qual Health Res 2022; 32: 1399-1414. [PMID: 35622710 DOI: 10.1177/10497323221104718]

[10] Thaut MH. Neurologic music therapy in cognitive rehabilitation. Music Percept 2010; 27: 281-285. [DOI: 10.1525/mp.2010.27.4.281]

[11] Fan LP, Quijano-Ruiz A, Wang C, Zhao HW, Wang DN, et al. Effects of personalized music listening on post-stroke cognitive impairment: a randomized controlled trial. Complement Ther Clin Pract 2024; 57: 101885. [PMID: 39098085 DOI: 10.1016/j.ctcp.2024.101885]

[12] Liu Q, Liu L, Liu Z, Xu Y, Wang F, et al. Reminiscent music therapy combined with robot-assisted rehabilitation for elderly stroke patients: a pilot study. J Neuroeng Rehabil 2024; 21: 16. [PMID: 38291426 DOI: 10.1186/s12984-024-01315-y]

[13] Schlaug G, Norton A, Marchina S, Zipse L, Wan CY. From singing to speaking: facilitating recovery from nonfluent aphasia. Future Neurol 2010; 5: 657-665. [PMID: 21088709 DOI: 10.2217/fnl.10.44]

[14] García-Casares N, Barros-Cano A, García-Arnés JA. Melodic intonation therapy in post-stroke non-fluent aphasia and its effects on brain plasticity. J Clin Med 2022; 11: 3503. [PMID: 35743571 DOI: 10.3390/jcm11123503]

[15] Hou P-W, Hsu H-C, Lin Y-W, Tang N-Y, Cheng C-Y, et al. The history, mechanism, and clinical application of auricular therapy in traditional Chinese medicine. Evid Based Complement Alternat Med 2015; 2015: 495684. [PMID: 26823672 DOI: 10.1155/2015/495684]

[16] Lee SH, Lee KJ, Song CH. Effects of rhythmic auditory stimulation (RAS) on gait ability and symmetry after stroke. J Phys Ther Sci 2012; 24: 311-314. [DOI: 10.1589/jpts.24.311]

[17] Du B, Sun T. The application and development of music therapy in rehabilitation medicine. J Contemp Educ Res 2024; 8: 283-289. [DOI: 10.26689/jcer.v8i7.7812]

[18] Xu C, He Z, Shen Z, Huang F. Potential benefits of music therapy on stroke rehabilitation. Oxid Med Cell Longev 2022; 2022: 9386095. [PMID: 35757506 DOI: 10.1155/2022/9386095]

[19] Koger SM, Chapin K, Brotons M. Is music therapy an effective intervention for dementia? A meta-analytic review of literature. J Music Therapy 1999; 36: 2-15. [PMID: 10519841 DOI: 10.1093/jmt/36.1.2]

[20] Lin S-T, Yang P, Lai C-Y, Su Y-Y, Yeh Y-C, et al. Mental health implications of music: insight from neuroscientific and clinical studies. Har Rev Psychiatry 2011; 19: 34-46. [PMID: 21250895 DOI: 10.3109/10673229.2011.549769]

[21] Brungardt A, Wibben A, Tompkins AF, Shanbhag P, Coats H, et al. Virtual reality-based music therapy in palliative care: a pilot implementation trial. J Palliat Med 2021; 24: 736-742. [PMID: 33227225 DOI: 10.1089/jpm.2020.0403]

[22] Xu W, Liu L, Zhang J. Application analysis based on big data technology in stroke rehabilitation nursing. J Healthc Eng 2021; 2021: 3081549. [PMID: 34900181 DOI: 10.1155/2021/3081549]

[23] Xiang C, Huo W. Research progress on the use of music therapy combined with transcranial magnetic stimulation to treat cognitive impairment after stroke. Clin Neurosci Res 2024; 2: 49-53. [DOI: 10.26689/cnr.v2i1.6280]

[24] Ard J, Wheeler BL . Music therapy and stroke: an integrative review. Music Medicine 2016; 8: 146. [DOI: 10.47513/mmd.v8i4.496]

[25] Micera S, Caleo M, Chisari C, Hummel FC, Pedrocchi A. Advanced neurotechnologies for the restoration of motor function. Neuron 2020; 105: 604-620. [PMID: 32078796 DOI: 10.1016/j.neuron.2020.01.039]

[26] Katan M, Luft A. Global burden of stroke. Semin Neurol 2018; 38: 208-211. [PMID: 29791947 DOI: 10.1055/s-0038-1649503]

[27] Purdie H. Music therapy with adults who have traumatic brain injury and stroke. Br J Music Ther 1997; 11: 45-50. [DOI: 10.1177/135945759701100203]

[28] Dimyan MA, Cohen LG. Neuroplasticity in the context of motor rehabilitation after stroke. Nat Rev Neurol 2011; 7: 76-85. [DOI: 10.1038/nrneurol.2010.200]

[29] Jayaram G, Stagg CJ, Esser P, Kischka U, Stinear J, et al. Relationships between functional and structural corticospinal tract integrity and walking post stroke. Clin Neurophysiol 2012; 123: 2422-2428. [PMID: 22717679 DOI: 10.1016/j.clinph.2012.04.026]

[30] Levin MF, Panturin E. Sensorimotor integration for functional recovery and the Bobath approach. Motor Control 2011; 15: 285-301. [PMID: 21628730 DOI: 10.1123/mcj.15.2.285]

[31] Thaut MH, Leins AK, Rice RR, Argstatter H, Kenyon GP, et al. Rhythmic auditory stimulation improves gait more than NDT/Bobath training in near-ambulatory patients early poststroke: a single-blind, randomized trial. Neurorehabil Neural Repair 2007; 21: 455-459. [PMID: 17426347 DOI: 10.1177/1545968307300523]

[32] Nys GMS, Van Zandvoort MJE, De Kort PLM, Jansen BPW, De Haan EHF, et al. Cognitive disorders in acute stroke: prevalence and clinical determinants. Cerebrovasc Dis 2007; 23: 408-416. [PMID: 17406110 DOI: 10.1159/000101464]

[33] Browne SE, Lin L, Mattsson A, Georgievska B, Isacson O. Selective antibody-induced cholinergic cell and synapse loss produce sustained hippocampal and cortical hypometabolism with correlated cognitive deficits. Exp Neurol 2001; 170: 36-47. [PMID: 11421582 DOI: 10.1006/exnr.2001.7700]

[34] Cumming TB, Bernhardt J, Linden T. The montreal cognitive assessment: short cognitive evaluation in a large stroke trial. Stroke 2011; 42: 2642-2644. [PMID: 21757673 DOI: 10.1161/STROKEAHA.111.619486]

[35] Armour M, Cherney LR, Del Toro CM, Maher LM, Raymer AM. Aphasia FAQs for the rehabilitation professional. Arch Phys Med Rehabil 2021; 102: 1243-1245. [PMID: 33775389 DOI: 10.1016/j.apmr.2021.01.068]

[36] Ogar JM, Dronkers NF, Brambati SM, Miller BL, Gorno-Tempini ML. Progressive nonfluent aphasia and its characteristic motor speech deficits. Alzheimer Dis Assoc Disord 2007; 21: S23-S30. [PMID: 18090419 DOI: 10.1097/WAD.0b013e31815d19fe]

[37] Barletta V, Calvano M, Curci A, Piccinno A. A new interactive paradigm for speech therapy. In: Abdelnour Nocera J, Kristín Lárusdóttir M, Petrie H, Piccinno A, Winckler M, editors. Human-computer interaction - INTERACT 2023. Lecture notes in computer science. Cham: Springer Nature Switzerland; 2023. pp. 380-385. [DOI: 10.1007/978-3-031-42293-5_39]

[38] Agarwal A, Iqbaal H. Serum-cortisol levels in severity of stroke. Int J Med Biomed Stud 2020; 4: 970. [DOI: 10.32553/ijmbs.v4i2.970]

[39] Liang R, Qian L. The application and advantages of music therapy in the rehabilitation of the elderly. MedSci 2024; 1. [DOI: 10.61173/vq9ymv67]

[40] Galińska E. Music therapy in neurological rehabilitation settings. Psychiatr Pol 2015; 49: 835-846. [PMID: 26488358 DOI: 10.12740/PP/25557]

[41] Fujioka T, Ross B, Trainor LJ. Beta-band oscillations represent auditory beat and its metrical hierarchy in perception and imagery. J Neurosci 2015; 35: 15187-15198. [PMID: 26558788 DOI: 10.1523/JNEUROSCI.2397-15.2015]

[42] Rota G, Sitaram R, Veit R, Erb M, Weiskopf N, et al. Self-regulation of regional cortical activity using real-time fMRI: the right inferior frontal gyrus and linguistic processing. Hum Brain Mapp 2009; 30: 1605-1614. [PMID: 18661503 DOI: 10.1002/hbm.20621]

[43] Kawahata I, Kawahata I, Hasegawa K, Kase R. Music and dopamine - potential in movement disorders. J Brain Nerves 2020: 1-4. [DOI: 10.31487/j.JBN.2020.01.02]

[44] Lin F-C, Huang D-H, He N-N, Qin Y-H, Li S-D, et al. Influence of traditional Chinese medicine five-element musical therapy on depression severity and neurological functional deficit scale in patients with post-stroke depression. 2016 8th International Conference on Information Technology in Medicine and Education (ITME); Fuzhou: IEEE; 2016; 199-208. [DOI: 10.1109/ITME.2016.0054]

[45] Vijayalakshmi K, Sridhar S, Khanwani P. Estimation of effects of alpha music on EEG components by time and frequency domain analysis. International Conference on Computer and Communication Engineering (ICCCE’10); Kuala Lumpur, Malaysia: IEEE; 2010: 1-5. [DOI: 10.1109/ICCCE.2010.5556761]

[46] Williams E, Dingle GA, Clift S. A systematic review of mental health and wellbeing outcomes of group singing for adults with a mental health condition. Eur J Public Health 2018; 28: 1035-1042. [PMID: 29982515 DOI: 10.1093/eurpub/cky115]

[47] Mangiacotti A, Hsu MH, Barone C, Di Liberto G, Van Puyvelde M, et al. P3-465: Effects of music therapy in elderly care: cognition, biomarkers, mood and social behaviour. Alzheimer’s & Dementia 2019; 15: P1144. [DOI: 10.1016/j.jalz.2019.06.3500]

[48] Särkämö T, Soto D. Music listening after stroke: beneficial effects and potential neural mechanisms. Ann N Y Acad Sci 2012; 1252: 266-281. [PMID: 22524369 DOI: 10.1111/j.1749-6632.2011.06405.x]

[49] George EM, Coch D . Music training and working memory: an ERP study. Neuropsychologia 2011; 49: 1083-1094. [PMID: 21315092 DOI: 10.1016/j.neuropsychologia.2011.02.001]

[50] Mainka S, Wissel J, Völler H, Evers S. The use of rhythmic auditory stimulation to optimize treadmill training for stroke patients: a randomized controlled trial. Front Neurol 2018; 9: 755. [PMID: 30271375 DOI: 10.3389/fneur.2018.00755]

[51] Capato TTC, De Vries NM, IntHout J, Ramjith J, Barbosa ER, et al. Multimodal balance training supported by rhythmic auditory stimuli in parkinson disease: effects in freezers and nonfreezers. Phys Ther 2020; 100: 2023-2034. [PMID: 32737973 DOI: 10.1093/ptj/pzaa146]

[52] Chen Y, Baran M, Sundaram H, Rikakis T. A low cost, adaptive mixed reality system for home-based stroke rehabilitation. Annu Int Conf IEEE Eng Med Biol Soc 2011; 2011: 1827-1830. [PMID: 22254684 DOI: 10.1109/IEMBS.2011.6090520]

[53] Marchina S, Norton A, Schlaug G. Effects of melodic intonation therapy in patients with chronic nonfluent aphasia. Ann N Y Acad Sci 2023; 1519: 173-185. [PMID: 36349876 DOI: 10.1111/nyas.14927]

[54] Tabei KI, Satoh M, Nakano C, Ito A, Shimoji Y, et al. Improved neural processing efficiency in a chronic aphasia patient following melodic intonation therapy: a neuropsychological and functional MRI study. Front Neurol 2016; 7: 148. [PMID: 27698650 DOI: 10.3389/fneur.2016.00148]

[55] Zhang X, Li J, Du Y. Melodic intonation therapy on non-fluent aphasia after stroke: a systematic review and analysis on clinical trials. Front Neurosci 2022; 15: 753356. [PMID: 35153655 DOI: 10.3389/fnins.2021.753356]

[56] Rubi-Fessen I, Hartmann A, Huber W, Fimm B, Rommel T, et al. Add-on effects of repetitive transcranial magnetic stimulation on subacute aphasia therapy: enhanced improvement of functional communication and basic linguistic skills. A randomized controlled study. Arch Phys Med Rehabil 2015; 96: 1935-1944.e2. [PMID: 26189201 DOI: 10.1016/j.apmr.2015.06.017]

[57] Kim SJ. Music therapy protocol development to enhance swallowing training for stroke patients with dysphagia. J Music Ther 2010; 47: 102-119. [PMID: 21141768 DOI: 10.1093/jmt/47.2.102]

[58] Dong Y, Badrin S, Badrin S, Tang L. Post-stroke fatigue interventions for stroke survivors: a scoping review. Belitung Nurs J 2024; 10: 601-613. [PMID: 39601026 DOI: 10.33546/bnj.3526]

[59] Cooper CL, Phillips LH, Johnston M, Whyte M, MacLeod MJ. The role of emotion regulation on social participation following stroke. Br J Clin Psychol 2015; 54: 181-199. [PMID: 25272054 DOI: 10.1111/bjc.12068]

[60] Hou X. The application of music therapy in autism spectrum disorder, depression, and anxiety: effects on symptom relief, social skill enhancement, and emotional regulation. Adv Humanit Res 2024; 10: 23-27. [DOI: 10.54254/2753-7080/2024.18280]

[61] Yuan B, Xu X, Xie Z, Lin F, Wu Y. Effects of five-element music on post-stroke depression: a systematic review and meta-analysis. 2021 11th International Conference on Information Technology in Medicine and Education (ITME); Wuyishan, Fujian, China: IEEE; 2021: 364-373. [DOI: 10.1109/ITME53901.2021.00080]

[62] Zhang J, Zhao Y, Li H, Yang Y, Tang Q. Effectiveness of acupuncture plus music therapy for post-stroke depression: systematic review and meta-analysis. Medicine 2024; 103: e39681. [PMID: 39287303 DOI: 10.1097/MD.0000000000039681]

[63] Zhang H, Lai H. Five phases music therapy (FPMT) in Chinese medicine: fundamentals and application. Open Access Lib J 2017; 4: 1-11. [DOI: 10.4236/oalib.1104190]

[64] Obembe AO, Eng JJ. Rehabilitation interventions for improving social participation after stroke: a systematic review and meta-analysis. Neurorehabil Neural Repair 2016; 30: 384-392. [PMID: 26223681 DOI: 10.1177/1545968315597072]

[65] Raukola-Lindblom M, Elina V, Riitta V. Recovering social participation - experience with a relational group intervention for traumatic brain injury patients. NeuroRehabilitation 2020; 47: 55-64. [PMID: 32675427 DOI: 10.3233/NRE-203083]

[66] Tamplin J, Loveridge B, Clarke K, Li Y, J Berlowitz D . Development and feasibility testing of an online virtual reality platform for delivering therapeutic group singing interventions for people living with spinal cord injury. J Telemed Telecare 2020; 26: 365-375. [PMID: 30823854 DOI: 10.1177/1357633X19828463]

[67] Särkämö T. Singing for rehabilitation. In: Heydon R, Fancourt D, Cohen AJ, editors. The Routledge companion to interdisciplinary studies in singing. Routledge; 2020. pp. 98-108. [DOI: 10.4324/9781315162546-8]

[68] Good A, Earle E, Vezer E, Gilmore S, Livingstone S, et al. Community choir improves vocal production measures in individuals living with Parkinson’s disease. J Voice 2025; 39: 848.e7-848.e20. [PMID: 36642592 DOI: 10.1016/j.jvoice.2022.12.001]

[69] Peretti O, Spyridis Y, Sesis A, Efstathopoulos G. Gamified First Responder Training Solution in Virtual Reality. 2021 17th International Conference on Distributed Computing in Sensor Systems (DCOSS); Pafos, Cyprus: IEEE; 2021: 295-301. [DOI: 10.1109/DCOSS52077.2021.00055]

[70] Bryant L, Brunner M, Hemsley B. A review of virtual reality technologies in the field of communication disability: implications for practice and research. Disabil Rehabil Assist Technol 2020; 15: 365-372. [PMID: 30638092 DOI: 10.1080/17483107.2018.1549276]

[71] Devane N, Behn N, Marshall J, Ramachandran A, Wilson S, et al. The use of virtual reality in the rehabilitation of aphasia: a systematic review. Disabil Rehabil 2023; 45: 3803-3822. [PMID: 36326199 DOI: 10.1080/09638288.2022.2138573]

[72] Van Der Kooij K, Van Dijsseldonk R, Van Veen M, Steenbrink F, De Weerd C, et al. Gamification as a sustainable source of enjoyment during balance and gait exercises. Front Psychol 2019; 10: 294. [PMID: 30881322 DOI: 10.3389/fpsyg.2019.00294]

[73] Colverson A, Barsoum S, Cohen R, Williamson J. Rhythmic musical activities may strengthen connectivity between brain networks associated with aging-related deficits in timing and executive functions. Exp Gerontol 2024; 186: 112354. [PMID: 38176601 DOI: 10.1016/j.exger.2023.112354]

[74] Stewart NAJ, Lonsdale AJ. It’s better together: the psychological benefits of singing in a choir. Psychol Music 2016; 44: 1240-1254. [DOI: 10.1177/0305735615624976]

[75] Lossing A, Moore M, Zuhl M. Dance as a treatment for neurological disorders. Body Mov Dance Psych 2017; 12: 170-184. [DOI: 10.1080/17432979.2016.1260055]

[76] Ou J, Xu C, Fu Y, Chen Q, Han Y, et al. Post-stroke cognitive impairment: a bibliometric and knowledge-map analysis. NeuroRehabilitation 2023; 52: 175-186. [PMID: 36565073 DOI: 10.3233/NRE-220203]

[77] Koshimori Y, Thaut MH. New perspectives on music in rehabilitation of executive and attention functions. Front Neurosci 2019; 13: 1245. [PMID: 31803013 DOI: 10.3389/fnins.2019.01245]

[78] King JB, Jones KG, Goldberg E, Rollins M, MacNamee K, et al. Increased functional connectivity after listening to favored music in adults with Alzheimer dementia. J Prev Alzheimers Dis 2019; 6: 56-62. [PMID: 30569087 DOI: 10.14283/jpad.2018.19]

[79] Chan MMY, Han YMY. The functional brain networks activated by music listening: a neuroimaging meta-analysis and implications for treatment. Neuropsychology 2022; 36: 4-22. [PMID: 34636582 DOI: 10.1037/neu0000777]

[80] Vargas A, Díaz P, Zarraonandia T. Using virtual reality and music in cognitive disability therapy. Proceedings of the International Conference on Advanced Visual Interfaces; Salerno Italy: ACM; 2020; 35: 1-9. [DOI: 10.1145/3399715.3399916]

[81] Lesiuk T, Bugos JA, Murakami B. A rationale for music training to enhance executive functions in Parkinson’s disease: an overview of the problem. Healthcare 2018; 6: 35. [PMID: 29690546 DOI: 10.3390/healthcare6020035]

[82] Wharton W, Goldstein FC, Zhao L, Steenland K, Levey AI, et al. O4-09-02: Certain antihypertensives may slow the conversion from mild cognitive impairment to Alzheimer’s disease. Alzheimers Dement 2015; 11: P290. [DOI: 10.1016/j.jalz.2015.07.394]

[83] Metasari S, Elisa E. Analysis of melodic intonation therapy (MIT) on speech ability in stroke patients with aphasia at Srondol health center. J Health Sci Med Ther 2024; 2: 181-190. [DOI: 10.59653/jhsmt.v2i03.974]

[84] Schlaug G, Marchina S, Norton A. From singing to speaking: why singing may lead to recovery of expressive language function in patients with Broca’s aphasia. Music Percept 2008; 25: 315-323. [PMID: 21197418 DOI: 10.1525/mp.2008.25.4.315]

[85] Zhang X, Talifu Z, Li J, Li X, Yu F. Melodic intonation therapy for non-fluent aphasia after stroke: a clinical pilot study on behavioral and DTI findings. iScience 2023; 26: 107453. [PMID: 37744405 DOI: 10.1016/j.isci.2023.107453]

[86] Li X, Liu J, Wei S, Yu C, Wang D, et al. Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study. BMC Med 2024; 22: 253. [PMID: 38902735 DOI: 10.1186/s12916-024-03443-7]

[87] Sihvonen AJ, Leo V, Ripollés P, Lehtovaara T, Ylönen A, et al. Vocal music enhances memory and language recovery after stroke: pooled results from two RCTs. Ann Clin Transl Neurol 2020; 7: 2272-2287. [PMID: 33022148 DOI: 10.1002/acn3.51217]

[88] Raglio A, Oasi O, Gianotti M, Rossi A, Goulene K, et al. Improvement of spontaneous language in stroke patients with chronic aphasia treated with music therapy: a randomized controlled trial. Int J Neurosci 2016; 126: 235-242. [PMID: 26000622 DOI: 10.3109/00207454.2015.1010647]

[89] Good DC. Treatment strategies for enhancing motor recovery in stroke rehabilitation. Neurorehabil Neural Repair 1994; 8: 177-186. [DOI: 10.1177/136140969400800402]

[90] Arsovski D. The benefits of music therapy in stroke rehabilitation: a systematic literature review. Multidiscip Pristup Eduk Rehabil 2024; 6: 113-123. [DOI: 10.59519/mper6112]

[91] Silkis IG. Possible mechanisms of interdependent roles of the basal ganglia and cerebellum in the functioning of motor and sensory systems. Integr Physiol 2021; 2: 135-146. [DOI: 10.33910/2687-1270-2021-2-2-135-146]

[92] Ye X, Li L, He R, Jia Y, Poon W. Rhythmic auditory stimulation promotes gait recovery in Parkinson’s patients: a systematic review and meta-analysis. Front Neurol 2022; 13: 940419. [PMID: 35968291 DOI: 10.3389/fneur.2022.940419]

[93] Rosati G, Oscari F, Reinkensmeyer DJ, Secoli R, Avanzini F, et al. Improving robotics for neurorehabilitation: enhancing engagement, performance, and learning with auditory feedback. IEEE Int Conf Rehabil Robot 2011; 2011: 5975373. [PMID: 22275577 DOI: 10.1109/ICORR.2011.5975373]

[94] Liu Q, Liu L, Wu H, Liu Y. Effects of reminiscent music therapy with robot-assisted rehabilitation for poststroke recovery older Chinese. Innov Aging 2024; 8: 109- 109. [DOI: 10.1093/geroni/igae098.0350]

[95] Costa-Giomi E. Does music instruction improve fine motor abilities? Ann N Y Acad Sci 2005; 1060: 262-264. [PMID: 16597773 DOI: 10.1196/annals.1360.053]

[96] Seitz RJ, Matyas TA, Carey LM. Neural plasticity as a basis for motor learning and neurorehabilitation. Brain Impair 2008; 9: 103-113. [DOI: 10.1375/brim.9.2.103]

[97] Kim SJ, Yeo MS, Kim SY, Kang SY. A scoping review of music-based interventions for swallowing difficulties: implications for treating older adults with presbyphagia. Front Med 2023; 10: 1285835. [PMID: 38034547 DOI: 10.3389/fmed.2023.1285835]

[98] Yeo MS, Hwang J, Lee HK, Kim SJ, Cho SR. Therapeutic singing-induced swallowing exercise for dysphagia in advanced-stage Parkinson’s disease. Front Neurol 2024; 15: 1323703. [PMID: 38628693 DOI: 10.3389/fneur.2024.1323703]

[99] Aravantinou-fatorou A, Georgakopoulou V, Spandidos D, Papalexis P, Tarantinos K, et al. Effects of music therapy accompanied by transcranial direct current stimulation on the recovery from aphasia following stroke: a single-center retrospective cohort study. World Acad Sci J 2022; 4: 42. [DOI: 10.3892/wasj.2022.177]

[100] Yildirim D, Çiriş Yildiz C, Ozdemir FA, Harman Özdoğan M, Can G. Effects of a mindfulness-based stress reduction program on stress, depression, and psychological well-being in patients with cancer: a single-blinded randomized controlled trial. Cancer Nurs 2024; 47: E84-E92. [PMID: 36480346 DOI: 10.1097/NCC.0000000000001173]

[101] Optale G, Capodieci S, Pinelli P, Zara D, Gamberini L, et al. Music-enhanced immersive virtual reality in the rehabilitation of memoryrelated cognitive processes and functional abilities: a case report. Presence Teleop Virt Environ 2001; 10: 450-462. [DOI: 10.1162/1054746011470217]

[102] Amirthalingam J, Paidi G, Alshowaikh K, Iroshani Jayarathna A, Salibindla DBAMR, et al. Virtual reality intervention to help improve motor function in patients undergoing rehabilitation for cerebral palsy, Parkinson’s disease, or stroke: a systematic review of randomized controlled trials. Cureus 2021; 13: e16763. [PMID: 34367835 DOI: 10.7759/cureus.16763]

[103] Nemade B, Prajapati S, Thorat Y, Khadke A. AI based music recommendation system using deep learning. Int Res J Mod Eng Technol Sci 2024. [DOI: 10.56726/IRJMETS47832]

[104] Coulton S, Clift S, Skingley A, Rodriguez J. Effectiveness and cost-effectiveness of community singing on mental health-related quality of life of older people: randomised controlled trial. Br J Psychiatry 2015; 207: 250-255. [PMID: 26089304 DOI: 10.1192/bjp.bp.113.129908]

[105] Lam So RW, Wong HS, Ko KM. A Traditional Chinese medicine approach in treating depression by promoting liver Qi circulation: a western medicine perspective. Chinese Med 2015; 06: 187-195. [DOI: 10.4236/cm.2015.64021]

[106] van der Meulen I, van de Sandt-Koenderman WM, Heijenbrok-Kal MH, Visch-Brink EG, Ribbers GM. The efficacy and timing of melodic intonation therapy in subacute aphasia. Neurorehabil Neural Repair 2014; 28: 536-544. [PMID: 24449708 DOI: 10.1177/1545968313517753]

[107] Hayden R, Clair AA, Johnson G, Otto D. The effect of rhythmic auditory stimulation (RAS) on physical therapy outcomes for patients in gait training following stroke: a feasibility study. Int J Neurosci 2009; 119: 2183-2195. [PMID: 19916847 DOI: 10.3109/00207450903152609]

[108] Fotakopoulos G, Kotlia P. The value of exercise rehabilitation program accompanied by experiential music for recovery of cognitive and motor skills in stroke patients. J Stroke Cerebrovasc Dis 2018; 27: 2932-2939. [PMID: 30072173 DOI: 10.1016/j.jstrokecerebrovasdis.2018.06.025]

[109] Reagon C, Gale N, Enright S, Mann M, Van Deursen R. A mixed-method systematic review to investigate the effect of group singing on health related quality of life. Complement Ther Med 2016; 27: 1-11. [PMID: 27515869 DOI: 10.1016/j.ctim.2016.03.017]

[110] Kostis JB, Dobrzynski JM. Limitations of randomized clinical trials. Am J Cardiol 2020; 129: 109-115. [PMID: 32560898 DOI: 10.1016/j.amjcard.2020.05.011]

[111] Hurkmans J, De Bruijn M, Boonstra AM, Jonkers R, Bastiaanse R, et al. Music in the treatment of neurological language and speech disorders: a systematic review. Aphasiology 2012; 26: 1-19. [DOI: 10.1080/02687038.2011.602514]

[112] Huang K, Itoh K, Kwee IL, Nakada T. Neural strategies for reading Japanese and Chinese sentences: a cross-linguistic fMRI study of character-decoding and morphosyntax. Neuropsychologia 2012; 50: 2598-2604. [PMID: 22820634 DOI: 10.1016/j.neuropsychologia.2012.07.011]

[113] Park MS, Choi JY, Song Y-J, Choi H, Park E-J, et al. Systematic review of behavioral therapy to improve swallowing functions of patients with Parkinson’s disease. Gastroenterol Nurs 2019; 42: 65-78. [PMID: 30585913 DOI: 10.1097/SGA.0000000000000358]

[114] Juhos-Kiss E, Vass L, Pusztafalvi H. Zeneterapeuták intézményi jelenléte a magyarországi aphasiaterápiában. Orvosi Hetilap 2023; 164: 747-752. [DOI: 10.1556/650.2023.32752]

[115] Murad D, Ye F, Barone M, Wang Y. Motion initiated music ensemble with sensors for motor rehabilitation. 2017 International Conference on Orange Technologies (ICOT); Singapore, Singapore: IEEE; 2017; 87-90. [DOI: 10.1109/ICOT.2017.8336095]

[116] Tuominen PPA, Saarni LA. The use of virtual technologies with music in rehabilitation: a scoping systematic review. Front Virtual Real 2024; 5: 1290396. [DOI: 10.3389/frvir.2024.1290396]

[117] Savle V, Sarvade P, Gavli R, Bidkar V, Chitari A, et al. Deep learning based song recommendation system using facial expression and heart rate. IOSR J Comput Eng 2024; 26: 1-7. [DOI: 10.9790/0661-2606010107]

[118] Ghozali MT. Predicting patient adherence in healthcare using artificial intelligence and machine learning techniques: a narrative review. 2024 8th International Conference on I-SMAC (IoT in Social, Mobile, Analytics and Cloud) (I-SMAC); Kirtipur, Nepal: IEEE; 2024; 1211-1215. [DOI: 10.1109/I-SMAC61858.2024.10714843]

[119] Li W, Shao C, Zhou H, Du H, Chen H, et al. Multi-omics research strategies in ischemic stroke: a multidimensional perspective. Ageing Res Rev 2022; 81: 101730. [PMID: 36087702 DOI: 10.1016/j.arr.2022.101730]

[120] Wang B, Yan T. Multi-modal neuroimaging technique: innovations and applications. Brain Sci Adv 2023; 9: 53-55. [DOI: 10.26599/BSA.2023.9050017]

[121] Hirst D. Melody metrics for prosodic typology: comparing English, French and Chinese. Interspeech 2013; 14: 572-576. [DOI: 10.21437/Interspeech.2013-158]

[122] Friedman N, Chan V, Zondervan D, Bachman M, Reinkensmeyer DJ. MusicGlove: motivating and quantifying hand movement rehabilitation by using functional grips to play music. 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society; Boston, MA: IEEE; 2011; 2359-2363. [DOI: 10.1109/IEMBS.2011.6090659]

[123] Ee C, Lake J, Firth J, Hargraves F, De Manincor M, et al. An integrative collaborative care model for people with mental illness and physical comorbidities. Int J Ment Health Syst 2020; 14: 83. [PMID: 33292354 DOI: 10.1186/s13033-020-00410-6]

[124] Mania I, Kaur J. Music combined with transcranial magnetic stimulation for the treatment of depression. Music Med 2020; 12: 253. [DOI: 10.47513/mmd.v12i4.750]

[125] Barwood CHS, Murdoch BE, Whelan B-M, Lloyd D, Riek S, et al. The effects of low frequency Repetitive Transcranial Magnetic Stimulation (rTMS) and sham condition rTMS on behavioural language in chronic non-fluent aphasia: short term outcomes. NeuroRehabilitation 2011; 28: 113-128. [PMID: 21447912 DOI: 10.3233/NRE-2011-0640]

[126] Ahluwalia MS, Vogelbaum MA, Chao ST, Mehta MM. Brain metastasis and treatment. F1000Prime Rep 2014; 6: 114. [PMID: 25580268 DOI: 10.12703/P6-114]

[127] Rajendran T, Summa-Chadwick M. The scope and potential of music therapy in stroke rehabilitation. J Integr Med 2022; 20: 284-287. [PMID: 35534380 DOI: 10.1016/j.joim.2022.04.006]

[128] McIntosh GC, Brown SH, Rice RR, Thaut MH. Rhythmic auditory-motor facilitation of gait patterns in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry 1997; 62: 22-26. [PMID: 9010395 DOI: 10.1136/jnnp.62.1.22]

[129] Abell RV, Baird AD, Chalmers KA. Group singing and health-related quality of life in Parkinson’s disease. Health Psychol 2017; 36: 55-64. [PMID: 27584976 DOI: 10.1037/hea0000412]

[130] Tamplin J, Baker FA, Grocke D, Berlowitz DJ. Thematic analysis of the experience of group music therapy for people with chronic quadriplegia. Top Spinal Cord Inj Rehabil 2014; 20: 236-247. [DOI: 10.1310/sci2003-236]

[131] Van Der Meulen I, Van De Sandt-Koenderman ME, Ribbers GM . Melodic intonation therapy: present controversies and future opportunities. Arch Phys Med Rehabil 2012; 93: S46-S52. [PMID: 22202191 DOI: 10.1016/j.apmr.2011.05.029]

[132] Sveistrup H. Motor rehabilitation using virtual reality. J NeuroEngineering Rehabil 2004; 1: 10. [PMID: 15679945 DOI: 10.1186/1743-0003-1-10]

[133] Hutchinson K, Sloutsky R, Collimore A, Adams B, Harris B, et al. A music-based digital therapeutic: proof-of-concept automation of a progressive and individualized rhythm-based walking training program after stroke. Neurorehabil Neural Repair 2020; 34: 986-996. [PMID: 33040685 DOI: 10.1177/1545968320961114]

[134] Verma P, Mishra N, Srivastava V. Machine learning for personalized medicine: tailoring treatment strategies through data analysis. Pharma Innovation 2019; 8: 11-14. [DOI: 10.22271/tpi.2019.v8.i3Sa.25249]

[135] Zhao X, Yang A, Zhang Z-C, Yang YT, Zhao X-M. Deciphering the genetic architecture of human brain structure and function: a brief survey on recent advances of neuroimaging genomics. Brief Bioinform 2023; 24: bbad060. [PMID: 36847697 DOI: 10.1093/bib/bbad060]

[136] Blum K, Simpatico T, Febo M, Rodriquez C, Dushaj K, et al. Hypothesizing music intervention enhances brain functional connectivity involving dopaminergic recruitment: common neuro-correlates to abusable drugs. Mol Neurobiol 2017; 54: 3753-3758. [PMID: 27246565 DOI: 10.1007/s12035-016-9934-y]

[137] Matrone C, Brattico E. The power of music on Alzheimer’s disease and the need to understand the underlying molecular mechanisms. J Alzheimers Dis Parkinsonism 2015; 5: 3. [DOI: 10.4172/2161-0460.1000196]

[138] Balikuddembe JK, Reinhardt JD. Can digitization of health care help low-resourced countries provide better community-based rehabilitation services? Phys Ther 2020; 100: 217-224. [PMID: 31680158 DOI: 10.1093/ptj/pzz162]

[139] Hadidi NN, Huna Wagner RL, Lindquist R. Nonpharmacological treatments for post-stroke depression: an integrative review of the literature. Res Gerontol Nurs 2017; 10: 182-195. [PMID: 28556875 DOI: 10.3928/19404921-20170524-02]

[140] Yousufuddin M, Young N. Aging and ischemic stroke. Aging 2019; 11: 2542-2544. [PMID: 31043575 DOI: 10.18632/aging.101931]

[141] Kemper KJ, Danhauer SC. Music as therapy. South Med J 2005; 98: 282-288. [PMID: 15813154 DOI: 10.1097/01.SMJ.0000154773.11986.39]

[142] Leschallier De Lisle G, Oudin A, Bourla A, Ferreri F, Mouchabac S . Musicotherapy mobile applications: what level of evidence and potential role in psychiatric care? A systematic review. Front Psychiatry 2024; 15: 1366575. [PMID: 38911704 DOI: 10.3389/fpsyt.2024.1366575]

[143] Chandan JS, Brown KR, Simms-Williams N, Bashir NZ, Camaradou J, et al. Non-pharmacological therapies for post-viral syndromes, including long COVID: a systematic review. Int J Environ Res Public Health 2023; 20: 3477. [PMID: 36834176 DOI: 10.3390/ijerph20043477]

[144] Breit S, Kupferberg A, Rogler G, Hasler G. Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders. Front Psychiatry 2018; 9: 44. [PMID: 29593576 DOI: 10.3389/fpsyt.2018.00044]