Ulvan and Ulva oligosaccharides from Ulva sp. attenuate osteoarthritis in a high-fat diet and ligamentous meniscal injury-induced rat model
Sabri Sudirman , Yi-Chia Lin , Yi-Yuh Hwang , Jerrell Felim , Hsiang-Ping Kuo , Deng-Fwu Hwang , Zwe-Ling Kong
Bioresources and Bioprocessing ›› 2026, Vol. 13 ›› Issue (1) : 28
Obesity / Osteoarthritis / Ulvan / Ulva oligosaccharide / Ulva sp
| [1] |
Akter A, Sobuj MKA, Islam MS, Chakroborty K, Tasnim N, Ayon MH, Hossain MF, Rafiquzzaman SM (2024) Seaweed polysaccharides: Sources, structure and biomedical applications with special emphasis on antiviral potentials. Future Foods 10 |
| [2] |
|
| [3] |
|
| [4] |
AOAC. Association of official analytical chemists. Association of official analytical chemists (AOAC) international 17th edition. 2000, Gaithersburg, MD, USA Association of Analytical Communities |
| [5] |
Bai W, Liu X, Fan Q, Guo B (2023) Effects of functional oligosaccharide on regulating gut microbiota in obese mice: a short review. Food Sci Technol 43 |
| [6] |
|
| [7] |
Burrage PS (2006) Matrix metalloproteinases: role in arthritis. Front Biosci 11. |
| [8] |
|
| [9] |
|
| [10] |
Cheong K-L, Qiu H-M, Du H, Liu Y, Khan BM (2018) Oligosaccharides Derived from Red Seaweed: Production, Properties, and Potential Health and Cosmetic Applications. Molecules 23 |
| [11] |
|
| [12] |
Chiu P-R, Hu Y-C, Huang T-C, Hsieh B-S, Yeh J-P, Cheng H-L, Huang L-W, Chang K-L (2016) Vitamin C protects chondrocytes against monosodium Iodoacetate-Induced osteoarthritis by multiple pathways. Int J Mol Sci 18 |
| [13] |
Choi M-C, Jo J, Park J, Kang HK, Park Y (2019) NF-κB signaling pathways in Osteoarthritic cartilage destruction. Cells 8. |
| [14] |
|
| [15] |
|
| [16] |
Flórez-Fernández N, Rodríguez-Coello A, Latire T, Bourgougnon N, Torres MD, Buján M, Muíños A, Muiños A, Meijide-Faílde R, Blanco FJ, Vaamonde-García C, Domínguez H (2023) Anti-inflammatory potential of Ulvan. Int J Biol Macromol 253 |
| [17] |
Gao J, Wu F, Yan M, Wang X, Chi Y, Zhang Y, Peng Y, Li M, Ni Y, Wen X (2024) Effects of brown seaweed oligosaccharides on obesity and constipation managements. J Food Sci 90 |
| [18] |
|
| [19] |
Hebbale D, Bhargavi R, Ramachandra TV (2019) Saccharification of macroalgal polysaccharides through prioritized cellulase producing bacteria. Heliyon 5 |
| [20] |
Hridayanka KSN, Duttaroy AK, Basak S (2024) Bioactive Compounds and Their Chondroprotective Effects for Osteoarthritis Amelioration: A Focus on Nanotherapeutic Strategies, Epigenetic Modifications, and Gut Microbiota. Nutrients 16 |
| [21] |
Huang C-J, McAllister MJ, Slusher AL, Webb HE, Mock JT, Acevedo EO (2015) Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation. Sports Medicine - Open 1 |
| [22] |
Hung Y-HR, Chen G-W, Pan C-L, Lin H-TV (2021) Production of Ulvan oligosaccharides with antioxidant and Angiotensin-Converting Enzyme-Inhibitory activities by microbial enzymatic hydrolysis. Fermentation 7. |
| [23] |
Hwang P-A, Kao T-T, Guo-Yu T, Hsu F-Y, Chang C-H (2023) Low-molecular-weight fucoidan ameliorates calcium-deficient-diet–induced bone loss and osteoarthritis via CaSR level regulation. J Funct Foods 111 |
| [24] |
|
| [25] |
Jim EL, Jim EL, Surya R, Permatasari HK, Nurkolis F (2025) Marine-Derived Polymers–Polysaccharides as promising natural therapeutics for atherosclerotic cardiovascular disease. Marine Drugs 23. |
| [26] |
|
| [27] |
|
| [28] |
Khotimchenko M, Tiasto V, Kalitnik A, Begun M, Khotimchenko R, Leonteva E, Bryukhovetskiy I, Khotimchenko Y (2020) Antitumor potential of carrageenans from marine red algae. Carbohydr Polym 246 |
| [29] |
Kidgell JT, Magnusson M, de Nys R, Glasson CRK (2019) Ulvan: A systematic review of extraction, composition and function. Algal Res 39 |
| [30] |
Kraiem M, Ben Hamouda S, Eleroui M, Ajala M, Feki A, Dghim A, Boujhoud Z, Bouhamed M, Badraoui R, Pujo JM, Essafi-Benkhadir K, Kallel H, Amara B (2024) I., Anti-Inflammatory and Immunomodulatory Properties of a Crude Polysaccharide Derived from Green Seaweed Halimeda tuna: Computational and Experimental Evidences. Marine Drugs 22 |
| [31] |
Kuyinu EL, Narayanan G, Nair LS, Laurencin CT (2016) Animal models of osteoarthritis: Classification, Update, and measurement of outcomes. J Orthop Surg Res 11 |
| [32] |
Lakhrem M, Eleroui M, Boujhoud Z, Feki A, Dghim A, Essayagh S, Hilali S, Bouhamed M, Kallel C, Deschamps N, Toffol Bd, Pujo JM, Badraoui R, Kallel H, Amara B, I (2024) Anti-Vasculogenic, Antioxidant, and Anti-Inflammatory activities of sulfated polysaccharide derived from codium tomentosum: Pharmacokinetic assay. Pharmaceuticals 17. |
| [33] |
|
| [34] |
Li C, Tang T, Du Y, Jiang L, Yao Z, Ning L, Zhu B (2023) Ulvan and Ulva oligosaccharides: a systematic review of structure, preparation, biological activities and applications. Bioresources Bioprocess 10 |
| [35] |
Li C, Wang H, Zhu B, Yao Z, Ning L (2024) Polysaccharides and oligosaccharides originated from green algae: structure, extraction, purification, activity and applications. Bioresources Bioprocess 11 |
| [36] |
Li X, Shen A, Xiao M, Li S, Yang W (2025) New insights on health benefits, interactions with food components and potential application of marine-derived sulfated polysaccharides: A review. Int J Biol Macromol 294 |
| [37] |
|
| [38] |
Liu D, Tang W, Yin J-Y, Nie S-P, Xie M-Y (2021) Monosaccharide composition analysis of polysaccharides from natural sources: hydrolysis condition and detection method development. Food Hydrocolloids 116 |
| [39] |
Liu L, Luo P, Yang M, Wang J, Hou W, Xu P (2022) The role of oxidative stress in the development of knee osteoarthritis: A comprehensive research review. Front Mol Biosci 9 |
| [40] |
|
| [41] |
Luan T, Hu S, Nie W, Liu J, Wang S, Jia L, Zhou J, An N, Wang Y, Cui Z, Mao Y (2023) Recent advances in marine oligosaccharides: A review of bioactivities and application. J Funct Foods 108 |
| [42] |
Malvis Romero A, Picado Morales JJ, Klose L, Liese A (2023) Enzyme-Assisted extraction of Ulvan from the green macroalgae Ulva fenestrata. Molecules 28. |
| [43] |
|
| [44] |
|
| [45] |
|
| [46] |
|
| [47] |
Mo’o FRC, Wilar G, Devkota HP, Wathoni N (2020) Ulvan, a polysaccharide from macroalga Ulva sp.: A review of Chemistry, biological activities and potential for food and biomedical applications. Appl Sci 10 |
| [48] |
|
| [49] |
|
| [50] |
|
| [51] |
Naomi R, Teoh SH, Embong H, Balan SS, Othman F, Bahari H, Yazid MD (2023) The Role of Oxidative Stress and Inflammation in Obesity and Its Impact on Cognitive Impairments—A Narrative Review. Antioxidants 12 |
| [52] |
Nielsen SS (2017) Total Carbohydrate by Phenol-Sulfuric Acid Method. Food Analysis Laboratory Manual, pp. 137–141 |
| [53] |
Ou J-Y, Liu F-L, Chen C-L, Fang M-C, Huang C-H (2024) Immunomodulatory effects of Ulva-derived polysaccharides, oligosaccharides, and residues in a murine model of delayed-type hypersensitivity. Bioscience of Microbiota, Food and Health 43, 128–134 |
| [54] |
|
| [55] |
|
| [56] |
|
| [57] |
|
| [58] |
|
| [59] |
Rodríguez-Iglesias P, Baltrusch KL, Díaz-Reinoso B, López-Álvarez M, Novoa-Carballal R, González P, González-Novoa A, Rodríguez-Montes A, Kennes C, Veiga MC, Torres MD, Domínguez H (2024) Hydrothermal extraction of Ulvans from Ulva spp. In a biorefinery approach. Science of The Total Environment 951. |
| [60] |
Salehi M, Rashidinejad A (2025) Multifaceted roles of plant-derived bioactive polysaccharides: A review of their biological functions, delivery, bioavailability, and applications within the food and pharmaceutical sectors. Int J Biol Macromol 290 |
| [61] |
|
| [62] |
|
| [63] |
Sohail R, Mathew M, Patel KK, Reddy SA, Haider Z, Naria M, Habib A, Abdin ZU, Razzaq Chaudhry W, Akbar A (2023) Effects of Non-steroidal Anti-inflammatory drugs (NSAIDs) and gastroprotective NSAIDs on the Gastrointestinal tract. A Narrative Review. Cureus |
| [64] |
|
| [65] |
|
| [66] |
|
| [67] |
|
| [68] |
|
| [69] |
Tsubaki S, Oono K, Hiraoka M, Ueda T, Onda A, Yanagisawa K, Azuma J-i (2014) Hydrolysis of green-tide forming Ulva spp. By microwave irradiation with polyoxometalate clusters. Green Chem 16 |
| [70] |
Wahlström N, Nylander F, Malmhäll-Bah E, Sjövold K, Edlund U, Westman G, Albers E (2020) Composition and structure of cell wall Ulvans recovered from Ulva spp. Along the Swedish West Coast. Carbohydrate Polymers 233. |
| [71] |
|
| [72] |
|
| [73] |
Wu R, Guo Y, Chen Y, Zhang J (2025) Osteoarthritis burden and inequality from 1990 to 2021: a systematic analysis for the global burden of disease study 2021. Scientific Reports 15. |
| [74] |
Zaitseva OO, Sergushkina MI, Khudyakov AN, Polezhaeva TV, Solomina ON (2022) Seaweed sulfated polysaccharides and their medicinal properties. Algal Res 68 |
| [75] |
Zayed A, El-Aasr M, Ibrahim A-RS, Ulber R (2020) Fucoidan characterization: determination of purity and physicochemical and chemical properties. Mar Drugs 18 |
| [76] |
Zhang Y, Jiang J, Xie J, Xu C, Wang C, Yin L, Yang L, Sung KL (2017) Combined effects of tumor necrosis factor–α and interleukin–1β on Lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts in?vitro. Experimental and Therapeutic Medicine |
The Author(s)
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