Unveiling the common mechanisms and therapeutic targets of medicinal herbs in acute pancreatitis: a network pharmacology and experimental validation approach
Yuxin Shi , Yan Jia , Ya Liu , Hanyue Wang , Honghui Liu , Yilin Huang , Peiyan Chen , Jie Peng
Bioresources and Bioprocessing ›› 2025, Vol. 12 ›› Issue (1)
Unveiling the common mechanisms and therapeutic targets of medicinal herbs in acute pancreatitis: a network pharmacology and experimental validation approach
| [1] |
Ahn YJ, Lim JW, Kim H (2020) Docosahexaenoic acid induces expression of NAD(P)H: Quinone oxidoreductase and Heme Oxygenase-1 through activation of Nrf2 in Cerulein-Stimulated pancreatic acinar cells. Antioxid (Basel), 9(11) |
| [2] |
Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege SS Acute pancreatitis classification working, G. (2013) classification of acute pancreatitis–2012: revision of the Atlanta classification and definitions by international consensus. Gut, 62(1), 102–111 |
| [3] |
Chen X, Zhang S, Xuan Z, Ge D, Chen X, Zhang J, Wang Q, Wu Y, Liu B (2017) The phenolic fraction of mentha Haplocalyx and its constituent Linarin ameliorate inflammatory response through inactivation of NF-kappaB and MAPKs in Lipopolysaccharide-Induced RAW264.7 cells. Molecules, 22(5) |
| [4] |
|
| [5] |
|
| [6] |
|
| [7] |
|
| [8] |
|
| [9] |
|
| [10] |
|
| [11] |
|
| [12] |
|
| [13] |
|
| [14] |
|
| [15] |
|
| [16] |
|
| [17] |
|
| [18] |
|
| [19] |
|
| [20] |
|
| [21] |
Li X-Y, Shen L, Ji H-F (2025a) Exploring the anti-Alzheimer’s disease mechanisms of edible medicinal plant Polygonum cuspidatum by integrating network pharmacology and molecular docking. Ind Crops Prod 231 |
| [22] |
|
| [23] |
|
| [24] |
|
| [25] |
|
| [26] |
Mottaghipisheh J, Taghrir H, Boveiri Dehsheikh A, Zomorodian K, Irajie C, Mahmoodi Sourestani M, Iraji A (2021) Linarin, a glycosylated flavonoid, with potential therapeutic attributes: a comprehensive review. Pharmaceuticals (Basel), 14(11) |
| [27] |
Oh MS, Kim SI, Sim YE, Park SH, Kang MK, Kang IJ, Lim SS, Kang YH (2023) Cirsium setidens water extracts containing Linarin block Estrogen Deprivation-Induced bone loss in mice. Int J Mol Sci, 24(2) |
| [28] |
|
| [29] |
Sang S, Han Y, Zhou H, Kang X, Gong Y (2025) Network Pharmacology and experimental analysis reveal Ethyl caffeate delays osimertinib resistance in lung cancer by suppression of MET. Cancer Cell Int, 25(1) |
| [30] |
|
| [31] |
Siddika T, Balasuriya N, Frederick MI, Rozik P, Heinemann IU, O’Donoghue P (2022) Delivery of active AKT1 to human cells. Cells, 11(23) |
| [32] |
Slamova K, Kapesova J, Valentova K (2018) Sweet flavonoids: Glycosidase-Catalyzed modifications. Int J Mol Sci, 19(7) |
| [33] |
Song TJ, Ke J, Chen F, Zhang JY, Zhang C, Chen HY (2022) Effect of SNHG11/miR-7-5p/PLCB1 axis on acute pancreatitis through inhibiting p38MAPK pathway. Cells, 12(1) |
| [34] |
|
| [35] |
|
| [36] |
|
| [37] |
Wang J, Wang Y, Chen Z, Liu B, Wang W, Li Y (2024a) Study on the mechanism of Shugan Lidan Xiaoshi granule in preventing acute pancreatitis based on network Pharmacology and molecular Docking. Heliyon, 10(5), e27365 |
| [38] |
|
| [39] |
|
| [40] |
Xu L, Wang T, Xu Y, Jiang C (2024a) Investigation of the Pharmacological mechanisms of Shenfu injection in acute pancreatitis through network Pharmacology and experimental validation. Heliyon, 10(18), e37491 |
| [41] |
|
| [42] |
|
| [43] |
|
| [44] |
|
| [45] |
|
| [46] |
|
| [47] |
|
| [48] |
|
The Author(s)
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