Sustainable lactic acid production from agricultural waste: a review of current techniques, challenges and future directions

Nurasyikin Abdul Rahman , Zainab Ngaini , Saba Farooq , Sabrina Chua Ai Ling , Puteri Nabilah Jefree Shahren

Bioresources and Bioprocessing ›› 2025, Vol. 12 ›› Issue (1) : 81

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Bioresources and Bioprocessing ›› 2025, Vol. 12 ›› Issue (1) :81 DOI: 10.1186/s40643-025-00923-3
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Sustainable lactic acid production from agricultural waste: a review of current techniques, challenges and future directions

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Abstract

The increasing demand for lactic acid (LA), driven by its applications in biodegradable plastics, food additives, pharmaceuticals, and cosmetics, necessitates the development of sustainable production methods. Traditional processes often rely on food-based feedstock, aggravating food security concerns. This review addresses the critical gap in utilising agricultural waste as a non-food feedstock for LA production, thereby reducing waste and promoting a circular economy. Current techniques are thoroughly explored, including fed-batch, batch, and continuous fermentation procedures, as well as the utilisation of various microbial strains, including Lactobacillus species. Recent developments in genetic engineering and innovative fermentation techniques are discussed, alongside challenges such as substrate variability and contamination. By highlighting the potential of agricultural residues, such as sugarcane bagasse, rice husk and corn stover, this review provides a roadmap for future research and industrial applications to enhance sustainability and efficiency in LA production.

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Biodegradation / Food / Green / Lignocellulose / Synthesis

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Nurasyikin Abdul Rahman, Zainab Ngaini, Saba Farooq, Sabrina Chua Ai Ling, Puteri Nabilah Jefree Shahren. Sustainable lactic acid production from agricultural waste: a review of current techniques, challenges and future directions. Bioresources and Bioprocessing, 2025, 12(1): 81 DOI:10.1186/s40643-025-00923-3

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References

[1]

Abd Alsaheb RA, Aladdin A, Othman N, et al. . Lactic acid applications in pharmaceutical and cosmeceutical industries. J Chem Pharm Res, 2015, 2015: 729-735

[2]

Abdel-Rahman MA, Sonomoto K. Opportunities to overcome the current limitations and challenges for efficient microbial production of optically pure lactic acid. J Biotechnol, 2016, 236: 176-192.

[3]

Abdel-Rahman MA, Tashiro Y, Sonomoto K. Recent advances in lactic acid production by microbial fermentation processes. Biotechnol Adv, 2013, 31: 877-902.

[4]

Abedi E, Hashemi SMB. Lactic acid production– producing microorganisms and substrates sources-state of Art. Heliyon, 2020, 6: e04974

[5]

Abedin MM, Chourasia R, Phukon LC, et al. . Lactic acid bacteria in the functional food industry: biotechnological properties and potential applications. Crit Rev Food Sci Nutr, 2024, 64: 1073010748

[6]

Acedos MG, Gómez-Pérez P, Espinosa T, et al. . New efficient meta-fermentation process for lactic acid production from municipal solid waste. Microb Cell Factories, 2022, 21: 233

[7]

Ahmad A, Banat F, Taher H. A review on the lactic acid fermentation from low-cost renewable materials: recent developments and challenges. Environ Technol Innov, 2020, 20: 101138

[8]

Ajala O, Olonade Y, Ajala MA, Akinpelu G (2020) Lactic acid production from Lignocellulose– A review of major challenges and selected solutions. ChemBioEng Rev 7. https://doi.org/10.1002/cben.201900018

[9]

Ajioka M, Enomoto K, Suzuki K, Yamaguchi A. The basic properties of poly(lactic acid) produced by the direct condensation polymerization of lactic acid. J Environ Polym Degrad, 1995, 3: 225-234.

[10]

Alexandri M, Schneider R, Mehlmann K, Venus J. Recent advances in d-Lactic acid production from renewable resources: case studies on Agro-Industrial waste streams. Food Technol Biotechnol, 2019, 57: 293-304.

[11]

Algiert-Zielińska B, Mucha P, Rotsztejn H. Lactic and lactobionic acids as typically moisturizing compounds. Int J Dermatol, 2019, 58: 374-379.

[12]

Alves de Oliveira R, Komesu A, Vaz Rossell CE, Maciel Filho R. Challenges and opportunities in lactic acid bioprocess design—From economic to production aspects. Biochem Eng J, 2018, 133: 219-239.

[13]

Augustiniene E, Valanciene E, Matulis P, et al. . Bioproduction of l- and d-lactic acids: advances and trends in microbial strain application and engineering. Crit Rev Biotechnol, 2022, 42: 342-360.

[14]

Bolmanis E, Dubencovs K, Suleiko A, Vanags J. Model predictive Control—A stand out among competitors for Fed-Batch fermentation improvement. Fermentation, 2023, 9: 206

[15]

Castillo Martinez FA, Balciunas EM, Salgado JM, et al. . Lactic acid properties, applications and production: A review. Trends Food Sci Technol, 2013, 30: 70-83.

[16]

Chen H, Huo W, Wang B, et al. . L-lactic acid production by simultaneous saccharification and fermentation of dilute Ethylediamine pre-treated rice straw. Ind Crops Prod, 2019, 141: 111749

[17]

Choi B, Tafur Rangel A, Kerkhoven EJ, Nygård Y. Engineering of Saccharomyces cerevisiae for enhanced metabolic robustness and L-lactic acid production from lignocellulosic biomass. Metab Eng, 2024, 84: 23-33.

[18]

Costa S, Summa D, Semeraro B, et al. . Fermentation as a strategy for Bio-Transforming waste into resources: lactic acid production from Agri-Food residues. Fermentation, 2021, 7: 3

[19]

Darwin, Cord-Ruwisch R, Charles W. Ethanol and lactic acid production from sugar and starch wastes by anaerobic acidification. Eng Life Sci, 2018, 18: 635-642.

[20]

Díaz AB, González C, Marzo C, et al. . Feasibility of exhausted sugar beet pulp as Raw material for lactic acid production. J Sci Food Agric, 2020, 100: 3036-3045.

[21]

Din NAS, Lim SJ, Maskat MY, et al. . Lactic acid separation and recovery from fermentation broth by ion-exchange resin: A review. Bioresour Bioprocess, 2021, 8: 31.

[22]

Djukić-Vuković A, Mladenović D, Ivanović J, et al. . Towards sustainability of lactic acid and poly-lactic acid polymers production. Renew Sustain Energy Rev, 2019, 108: 238-252.

[23]

Drishya PK, Reddy MV, Mohanakrishna G, et al. . Advances in microbial and Plant-Based biopolymers: synthesis and applications in Next-Generation materials. Macromol, 2025, 5: 21

[24]

I, Mousavi Khaneghah A, Barba FJ, et al. . Recent advancements in lactic acid production - a review. Food Res Int, 2018, 107: 763-770.

[25]

Fan R, Ebrahimi M, Czermak P. Anaerobic membrane bioreactor for continuous lactic acid fermentation. Membranes, 2017, 7: 26

[26]

Feng X, Shang J, Gu Z, et al. . Lactic acid chemical peeling in skin disorders. Clin Cosmet Investig Dermatol, 2024, 17: 901-909.

[27]

Ghaffar T, Irshad M, Anwar Z, et al. . Recent trends in lactic acid biotechnology: A brief review on production to purification. J Radiat Res Appl Sci, 2014, 7: 222-229.

[28]

Gupta V, Odaneth,Annamma A, Lali AM. Continuous fermentation using high cell density cell recycle system for L-lactic acid production. Prep Biochem Biotechnol, 2024, 54: 668-679.

[29]

Hassan SE-D, Abdel-Rahman MA, Roushdy MM, et al. . Effective biorefinery approach for lactic acid production based on co-fermentation of mixed organic wastes by Enterococcus durans BP130. Biocatal Agric Biotechnol, 2019, 20: 101203.

[30]

Hernández-Beltrán JU, Hernández-De Lira IO, Cruz-Santos MM, et al. . Insight into pretreatment methods of lignocellulosic biomass to increase biogas yield: current state, challenges, and opportunities. Appl Sci, 2019, 9: 3721

[31]

Huang H-C, Lee IJ, Huang C, Chang T-M. Lactic acid Bacteria and lactic acid for skin health and melanogenesis Inhibition. Curr Pharm Biotechnol, 2020, 21: 566-577.

[32]

Huang S, Xue Y, Yu B, et al. . A review of the recent developments in the bioproduction of polylactic acid and its precursors optically pure lactic acids. Mol Basel Switz, 2021, 26: 6446

[33]

Huang J, Wang J, Liu S. Advanced fermentation techniques for lactic acid production from agricultural waste. Fermentation, 2023, 9: 765

[34]

Huang Y, Wang Y, Shang N, Li P. Microbial fermentation processes of lactic acid: challenges, solutions, and future prospects. Foods, 2023, 12: 2311

[35]

Inkinen S, Hakkarainen M, Albertsson A-C, Södergård A. From lactic acid to Poly(lactic acid) (PLA): Characterization and Analysis of PLA and Its Precursors. Biomacromolecules, 2011, 12: 523-532.

[36]

Juturu V, Wu JC. Microbial production of lactic acid: the latest development. Crit Rev Biotechnol, 2016, 36: 967-977.

[37]

Kacaribu AA, Darwin D. Biotechnological lactic acid production from low-cost renewable sources via anaerobic microbial processes. BioTechnologia, 2024, 105: 179-194.

[38]

Kim J, Kim Y-M, Lebaka VR, Wee Y-J. Lactic acid for green chemical industry: recent advances in and future prospects for production technology, recovery, and applications. Fermentation, 2022, 8: 609

[39]

Komesu A, Oliveira J, Martins LH, et al. . Lactic acid production to purification: A review. BioResources, 2017, 12: 4364-4383.

[40]

Kumar A, Chinnappan B, Singh J (2020) Lactic Acid Production and its Application in pharmaceuticals. pp 467–484

[41]

Lee HV, Hamid SBA, Zain SK. Conversion of lignocellulosic biomass to nanocellulose: structure and chemical process. Sci World J, 2014, 2014: 631013

[42]

Leung AE, Raba A, Beckerle K, et al. . The enzymatic synthesis of perdeuterated D- and L-Lactic acid-d4 and polymerization of their lactides to polylactic acid. Bioengineering, 2025, 12: 575

[43]

Li X, Yang Y, Zhang B, et al. . Lactate metabolism in human health and disease. Signal Transduct Target Ther, 2022, 7: 305

[44]

Lian T, Wanqin Z, Cao Q, et al. . Efficient production of lactic acid from anaerobic co-fermentation of starch and nitrogen-rich agro-industrial waste using a batch system. Chem Eng J, 2023, 471: 144689

[45]

Lillington SP, Leggieri PA, Heom KA, O’Malley MA. Nature’s recyclers: anaerobic microbial communities drive crude biomass Deconstruction. Curr Opin Biotechnol, 2020, 62: 38-47.

[46]

Macias-Benitez S, Garcia-Martinez AM, Caballero Jimenez P et al (2020) Rhizospheric organic acids as biostimulants: monitoring feedbacks on soil microorganisms and biochemical properties. Front Plant Sci 11. (Citation has been added in the introduction section (line 11), in the paragraph under Figure 1.) https://doi.org/10.3389/fpls.2020.00633

[47]

Madhavan Nampoothiri K, Nair NR, John RP. An overview of the recent developments in polylactide (PLA) research. Bioresour Technol, 2010, 101: 8493-8501.

[48]

Manandhar A, Shah A. Techno-Economic analysis of the production of lactic acid from lignocellulosic biomass. Fermentation, 2023, 9: 641

[49]

Maraveas C. Production of sustainable and biodegradable polymers from agricultural waste. Polymers, 2020, 12: 1127

[50]

Mora-Villalobos JA, Montero-Zamora J, Barboza N, et al. . Multi-Product lactic acid Bacteria fermentations: A review. Fermentation, 2020, 6: 23

[51]

Narayanan N, Roychoudhury P, Srivastava A (2004) L(+)-Lactic acid fermentation and its product polymerization. Electron J Biotechnol ISSN 0717–3458. https://doi.org/10.2225/vol7-issue2-fulltext-7. Vol 7 Num 2 7:

[52]

Neelam K, Vijay S, Lalit S. Various techniques for the modification of starch and the applications of its derivatives. Int Res J Pharm, 2012, 3: 25-31

[53]

Nofar M, Sacligil D, Carreau PJ, et al. . Poly (lactic acid) blends: processing, properties and applications. Int J Biol Macromol, 2019, 125: 307-360.

[54]

Nwamba MC, Sun F, Mukasekuru MR, et al. . Trends and hassles in the microbial production of lactic acid from lignocellulosic biomass. Environ Technol Innov, 2021, 21: 101337

[55]

Ojo AO, de Smidt O. Lactic acid: A comprehensive review of production to purification. Processes, 2023, 11: 688

[56]

Olszewska-Widdrat A, Alexandri M, López-Gómez JP, et al. . Batch and continuous lactic acid fermentation based on A Multi-Substrate approach. Microorganisms, 2020, 8: 1084

[57]

Othman M, Ariff AB, Rios-Solis L, Halim M (2017) Extractive fermentation of lactic acid in lactic acid Bacteria cultivation: A review. Front Microbiol 8. https://doi.org/10.3389/fmicb.2017.02285

[58]

Panesar PS, Kaur S. Bioutilisation of agro-industrial waste for lactic acid production. Int J Food Sci Technol, 2015, 50: 2143-2151.

[59]

Parra-Ramírez D, Martinez A, Cardona CA. Lactic acid production from glucose and xylose using the lactogenic Escherichia coli strain JU15: experiments and techno-economic results. Bioresour Technol, 2019, 273: 86-92.

[60]

Peng L, Wang L, Che C et al (2013) Bacillus sp. strain P38: an efficient producer of l-lactate from cellulosic hydrolysate, with high tolerance for 2-furfural. Bioresour Technol 149:169–176. https://doi.org/10.1016/j.biortech.2013.09.047

[61]

Pérez-Alvarado O, Zepeda-Hernández A, Garcia-Amezquita LE et al (2022) Role of lactic acid bacteria and yeasts in sourdough fermentation during breadmaking: evaluation of postbiotic-like components and health benefits. Front Microbiol 13. https://doi.org/10.3389/fmicb.2022.969460

[62]

Pleissner D, Neu A-K, Mehlmann K, et al. . Fermentative lactic acid production from coffee pulp hydrolysate using Bacillus coagulans at laboratory and pilot scales. Bioresour Technol, 2016, 218: 167-173.

[63]

Ponce S, Debut A, Mora JR. Highly active Calcium-based heterogeneous catalysts prepared together with biomass and Biochar modifiers for the methanolysis of Poly(lactic Acid). J Polym Environ, 2025

[64]

Raman J, Kim J-S, Choi KR, et al. . Application of lactic acid Bacteria (LAB) in sustainable agriculture: advantages and limitations. Int J Mol Sci, 2022, 23: 7784

[65]

Ramezani Dana H, Ebrahimi F. Synthesis, properties, and applications of polylactic acid-based polymers. Polym Eng Sci, 2023, 63: 22-43.

[66]

Rawoof SAA, Kumar PS, Vo D-VN, et al. . Production of optically pure lactic acid by microbial fermentation: a review. Environ Chem Lett, 2021, 19: 539-556.

[67]

Remund B, Yilmaz B, Sokollik C. D-Lactate: implications for Gastrointestinal diseases. Children, 2023, 10: 945.

[68]

Ren Y, Wang X, Li Y, et al. . Lactic acid production by fermentation of biomass: recent achievements and perspectives. Sustainability, 2022, 14: 14434

[69]

Rodrigues C, Vandenberghe LPS, Woiciechowski AL et al (2017) 24 - Production and application of lactic acid. In: Pandey A, Negi S, Soccol CR (eds) Current developments in biotechnology and bioengineering. Elsevier, pp 543–556

[70]

Shan W, Yan Y, Li Y, et al. . Microbial tolerance engineering for boosting lactic acid production from lignocellulose. Biotechnol Biofuels Bioprod, 2023, 16: 78

[71]

Singhvi M, Zendo T, Sonomoto K (2018) Free lactic acid production under acidic conditions by lactic acid bacteria strains: challenges and future prospects. Appl Microbiol Biotechnol 102. https://doi.org/10.1007/s00253-018-9092-4

[72]

Sornlek W, Sae-Tang K, Watcharawipas A, et al. . D-Lactic acid production from sugarcane Bagasse by genetically engineered Saccharomyces cerevisiae. J Fungi, 2022, 8: 816

[73]

Sun S, Li H, Chen J, Qian Q. Lactic acid: no longer an inert and End-Product of Glycolysis. Physiol Bethesda Md, 2017, 32: 453-463.

[74]

Sun Y, Xu Z, Zheng Y, et al. . Efficient production of lactic acid from sugarcane molasses by a newly microbial consortium CEE-DL15. Process Biochem, 2019, 81: 132-138.

[75]

Thygesen A, Tsapekos P, Alvarado-Morales M, Angelidaki I. Valorization of municipal organic waste into purified lactic acid. Bioresour Technol, 2021, 342: 125933

[76]

Tian X, Chen H, Liu H, Chen J. Recent advances in lactic acid production by lactic acid Bacteria. Appl Biochem Biotechnol, 2021, 193: 4151-4171.

[77]

Torino MI, Font de Valdez G, Mozzi F (2015) Biopolymers from lactic acid bacteria. Novel applications in foods and beverages. Front Microbiol 6. https://doi.org/10.3389/fmicb.2015.00834

[78]

Valério P, Pereira M, Grande S, et al. . Lactic acid production: A context for sustainability and trends. IOSR J Environ Sci Toxicol Food Technol, 2024, 18: 60-69.

[79]

Velvizhi G, Balakumar K, Shetti NP, et al. . Integrated biorefinery processes for conversion of lignocellulosic biomass to value added materials: paving a path towards circular economy. Bioresour Technol, 2022, 343: 126151

[80]

Wang Y, Tashiro Y, Sonomoto K. Fermentative production of lactic acid from renewable materials: recent achievements, prospects, and limits. J Biosci Bioeng, 2015, 119: 10-18.

[81]

Wang Y, Liu J, Cai D, Zhao G. Co-generation of ethanol and l-lactic acid from corn stalk under a hybrid process. Biotechnol Biofuels, 2018, 11: 331

[82]

Wang Y, Wu J, Lv M et al (2021) Metabolism characteristics of lactic acid Bacteria and the expanding applications in food industry. Front Bioeng Biotechnol 9. https://doi.org/10.3389/fbioe.2021.612285

[83]

Wee Y-J, Kim J-N, Ryu H-W (2006) Biotechnological production of lactic acid and its recent applications food technol. Food Technol Biotechnol 44

[84]

Yadav N, Nain L, Khare SK. One-pot production of lactic acid from rice straw pretreated with ionic liquid. Bioresour Technol, 2021, 323: 124563

[85]

Yang S, Yu H, You Y, et al. . Effective lactic acid production from waste paper using Streptococcus thermophilus at low enzyme loading assisted by Gleditsia saponin. Carbohydr Polym, 2018, 200: 122-127.

[86]

Yankov D (2022) Fermentative lactic acid production from lignocellulosic feedstocks: from source to purified product. Front Chem 10. https://doi.org/10.3389/fchem.2022.823005

[87]

Yin F-W, Sun X-L, Zheng W-L, et al. . Development of a strategy for L-Lactic acid production by rhizopus oryzae using Zizania latifolia waste and cane molasses as carbon sources. Molecules, 2023, 28: 6234

[88]

Zapaśnik A, Sokołowska B, Bryła M. Role of lactic acid Bacteria in food preservation and safety. Foods, 2022, 11: 1283

Funding

Malaysian Pepper Board (NAT/F07/LLM/86248/2023)

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