Engineering growth phenotypes of Aspergillus oryzae for L-malate production

Abstract

•	A close correlation was found between the growth status of Aspergillus oryzae and L-malate production.
•	Adaptive evolution enhances growth status and capacity of L-malate production of Aspergillus oryzae.
•	Transcriptomic analysis and morphological characterization reveal the growth mechanism of Aspergillus oryzae.

Keywords

L-malate / Aspergillus oryzae / Adaptive evolution / Growth mechanism / Growth phenotypes

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Funding

the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(32021005)

the Key Program of the National Natural Science Foundation of China(22038005)

the Provincial Outstanding Youth Foundation of Jiangsu Province(BK20211529)

the Fundamental Research Funds for the Central Universities(JUSRP22031)