Pharmacokinetics, bioavailability and tissue distribution of chitobiose and chitotriose in rats

Abstract

•	Report of tissue distribution of chitobiose and chitotriose after intragastric administration in rats.
•	A trace detection method for the determination of chitobiose and chitotriose in rat serum and organs using UPLC–MS was developed and validated.
•	Our results reveal that chitobiose and chitotriose could be quickly absorbed into the blood, with an oral bioavailability of 0.32%–0.52% in rats.

Keywords

Chitobiose / Chitotriose / UPLC–MS / Pharmacokinetics / Tissue distribution

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Funding

The National Key R&D Program of China(2019YFD0901805)

The 111 Project(B18022)

Fundamental Research Funds for Central Universities of the Central South University

The Open Project Funding of the State Key Laboratory of Bioreactor Engineering, ECUST(ZDXM2019)