Effective utilization of wastewater for valuable validamycin A biosynthesis by Streptomyces hygroscopicus K2509 in plant-scale bioreactor

Abstract

Background

The continuous escalation in wastewater production with declining dependency on conventional resources as a result of rapid urbanization, increasing global water scarcity and growing population have initiated many researchers to look out for efficient means of utilizing wastewater. In this regard, an effectual process economizing approach has been achieved, upon utilizing the discharged wastewater from validamycin A recovery process in fermentation medium as a replacement of costly tap water.

Results

In this study, wastewater was successfully used as a fermentation medium for the production of validamycin A in plant-scale bioreactor. Moreover, a new strain Streptomyces hygroscopicus K2509 was screened showing a good production capability in this low-cost culture environment and showed maximum validamycin A production and productivity of 21.23 g/L and 0.29 g/L h, respectively. Execution of this study has managed the effective utilization of wastewater by reducing 12.42% production cost per kilogram of validamycin A in an environmental friendly way.

Conclusion

The novel successful approach for using process wastewater even on being executed in plant-scale bioreactor was proved cost effective. In short, the presented effective way of utilizing wastewater in study will definitely serve as potentially cheap fermentation medium upon replacing tremendously used expensive tap water.

Keywords

Fermentation / Wastewater / Validamycin A / Plant-scale bioreactor / Cost effective

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Funding

Wuhan Kernel Bio-tech Co., Ltd. (P.R. China)

National key research and development program(2017YFF0204602)