Synthesis of patterned enzyme–metal–organic framework composites by ink-jet printing

Abstract

Objectives

This report explores the possibility of synthesizing enzyme–metal–organic framework (MOF) composites by ink-jet printing.

Results

This study demonstrates that the direct synthesis of patterned enzyme–metal–organic framework (MOF) composites on various substrates including paper and polymeric films can be readily achieved by ink-jet printing bio-inks containing protein molecules, metal ions, and organic ligands loaded, respectively, in different cartridges. The formed Cytochrome c (Cyt c)–MOF composites on filter paper by ink-jet printing can be used for rapid detection of hydrogen peroxide in solution.

Conclusions

This technique opens possibilities of scalable, controllable, and designable fabrication of functional protein–MOF hybrid surface with promising applications in future bio-related application fields such as biosensing, wearable bioelectronics, artificial biomimetic membranes, and tissue engineering.

Keywords

Immobilized enzyme / Metal–organic frameworks / Ink-jet printing

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Funding

National Key Research and Development Plan of China(2016YFA0204300)

National Natural Science Foundation of China(21622603)