Bidirectional regulatory mechanisms of lipids and radiotherapy: Metabolic disorders, therapeutic interventions, and pan-cancer clinical insights

Abstract

Malignant tumors continue to pose a significant threat to global health. Emerging evidence suggests that abnormal blood lipid levels may influence tumor incidence, and cancer patients frequently exhibit dysregulated lipid profiles. Radiotherapy, a cornerstone in cancer treatment, has been demonstrated to modulate blood lipid levels in patients. Conversely, blood lipid concentrations can significantly impact the efficacy of radiotherapy and the incidence of associated complications. This comprehensive review delves into cutting-edge research illuminating the intricate bidirectional interplay between blood lipid profiles and radiotherapy efficacy in malignant tumor patients. At the same time, it investigates the promising potential of tailored dietary modulation strategies and novel lipid-lowering therapeutics to enhance treatment efficacy and patient prognosis.

Keywords

Radiotherapy / Blood lipids / Cancer / Lipid metabolism / Therapeutic efficacy

Acknowledgments

None.

Funding

This work was supported by the Natural Science Foundation of Sichuan Province (Grant No. 2023NSFSC0712).

Conflict of interest

Jiahua Lyu is an Editorial Board Member of this journal but was not in any way involved in the editorial and peer-review process conducted for this paper, directly or indirectly. Separately, the other author declares no known competing financial interests or personal relationships that could have influenced the work reported in this paper.

Author contributions

Conceptualization: Jiahua Lyu

Writing - original draft: Jinxia Wu

Writing - review & editing: Jiahua Lyu

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Availability of data

Not applicable.