Ensitrelvir postexposure prophylaxis for COVID-19: Translating trial efficacy into clinical practice

Md Mohsin Sarker

Asian Pacific Journal of Tropical Medicine ›› 2026, Vol. 19 ›› Issue (6) : 237 -238.

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Asian Pacific Journal of Tropical Medicine ›› 2026, Vol. 19 ›› Issue (6) :237 -238. DOI: 10.4103/apjtm.apjtm_277_26
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Ensitrelvir postexposure prophylaxis for COVID-19: Translating trial efficacy into clinical practice
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Md Mohsin Sarker. Ensitrelvir postexposure prophylaxis for COVID-19: Translating trial efficacy into clinical practice. Asian Pacific Journal of Tropical Medicine, 2026, 19 (6) : 237-238 DOI:10.4103/apjtm.apjtm_277_26

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Conflict of interest statement

The author declares no conflicts of interest.

Funding

No funding was received for this work.

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Ethical approval was not required for this article because no human participants, patient data, or identifiable information were involved.

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The author contributed to the conception, drafting, critical revision, and final approval of the manuscript.

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Edited by Zhang Q, Lei Y, Pan Y

References

[1]

Hayden FG, Shinkai M, Clark TW, Luetkemeyer AF, Sax PE, Hanage WP, et al. Ensitrelvir for Covid-19 postexposure prophylaxis in household contacts. N Engl J Med 2026; 394: 1905-1915.

[2]

Hammond J, Yunis C, Fountaine RJ, Luscan G, Burr AM, Zhang W, et al. Oral nirmatrelvir-ritonavir as postexposure prophylaxis for COVID-19. N Engl J Med 2024; 391(3): 224-234. doi: 10.1056/NEJMoa2309002.

[3]

Alpizar SA, Accini J, Anderson DC, Eysa B, Medina-Piñón I, Ohmagari N, et al. MOVe-AHEAD study group. Molnupiravir for intra-household prevention of COVID-19: The MOVe-AHEAD randomized, placebo-controlled trial. J Infect 2023; 87(5): 392-402. doi: 10.1016/ j.jinf.2023.08.016.

[4]

Shionogi & Co., Ltd. XOCOVA (ensitrelvir) prescribing information. [Online]. Available from: https://www.shionogi.com/content/dam/shionogi/si/products/pdf/xocova.pdf. [8 June 2026].

[5]

Shionogi & Co., Ltd. Shionogi announces approval in Japan of a supplemental indication for Xocova (ensitrelvir fumaric acid) for the post-exposure prophylaxis of COVID-19. Available from: https://www.shionogi.com/global/en/news/2026/03/20260323_1.html. [8 June 2026].

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