Knowledge, perceptions, and practice towards adverse events following immunization surveillance among vaccination workers in Zhejiang province, China

Abstract

Objective: To access the level of knowledge, perceptions, and practice towards adverse events following immunization (AEFI) surveillance among vaccination workers in Zhejiang province, China. Methods: This was a cross-sectional survey involving 768 vaccination workers. Data were collected using self-administered questionnaires and analyzed by using SAS 9.3 software. Knowledge, perceptions, and practice on AEFI surveillance were summarized using frequency tables. The mean±SD value was used as the cut-off for defining good (values≥mean) and poor (values<mean) knowledge, perceptions or practice. Binary logistic regression analysis was used to determine sociodemographic variables associated with knowledge, perceptions, and practice towards AEFI. Results: The proportions of good knowledge, perceptions and practice on AEFI surveillance were 78.13%, 57.81% and 66.15%, respectively. Having a higher education background, longer years of experience, previous training on AEFI and ≥30 years of age were factors associated with good knowledge, perceptions and practice on AEFI surveillance among vaccination workers. Conclusions: Over half of the respondents had good knowledge, perceptions and practice on AEFI surveillance work. Interventions on improving the vaccination workers’ knowledge, perceptions and practice on AEFI surveillance should be considered in order to develop a more effective surveillance system.

Keywords

Adverse events following immunization / Surveillance / Knowledge / Perception / Practice

References

[1] Asturias EJ, Wharton M, Pless R, MacDonald NE, Chen RT, Andrews N, et al. Contributions and challenges for worldwide vaccine safety: The Global Advisory Committee on Vaccine Safety at 15 years. Vaccine 2016; 34:3342-3349.

[2] Tomianovic D, Bauwens J, Heininger U, Bonhoeffer J. Global vaccine safety assessment: Challenges and opportunities. Pediatr Infect Dis J 2016; 35:446-448.

[3] Moro PL, Haber P, McNeil MM. Challenges in evaluating post-licensure vaccine safety: Observations from the Centers for Disease Control and Prevention. Expert Rev Vaccines 2019; 18:1091-1101.

[4] Pan X, Lv H, Liang H, Wang Y, Shen L, Chen F, et al. Surveillance on the adverse events following immunization with the pentavalent vaccine in Zhejiang, China. Human Vaccines Immunotherap 2022; 18:2021711.

[5] Gahunia J, Bigham M, Konrad S, Snow ME. Adverse events following immunization: Evaluating an enhanced nursing role for PHNs. Canad Nurse 2013; 109:16-20.

[6] Netterlid E, Mansson ME, Hakansson A. Surveillance of vaccine safety: Comparison of parental reports with routine surveillance and a clinical trial. Vaccine 2009; 27:2042-2047.

[7] Folb PI, Bernatowska E, Chen R, Clemens J, Dodoo AN, Ellenberg SS, et al. A global perspective on vaccine safety and public health: The Global Advisory Committee on Vaccine Safety. Am J Public Health 2004; 94:1926-1931.

[8] Hu Y, Li Q, Lin L, Chen E, Chen Y, Qi X. Surveillance for adverse events following immunization from 2008 to 2011 in Zhejiang Province, China. Clin Vaccine Immunol 2013; 20:211-217.

[9] Liu D, Wu W, Li K, Xu D, Ye J, Li L, et al. Surveillance of adverse events following immunization in China: Past, present, and future. Vaccine 2015; 33:4041-4046.

[10] McNeil MM, Li R, Pickering S, Real TM, Smith PJ, Pemberton MR. Who is unlikely to report adverse events after vaccinations to the Vaccine Adverse Event Reporting System (VAERS)? Vaccine 2013; 31:2673-2679.

[11] Effendi DE, Laksono AD, Pranata S, Nantabah ZK. Prevalence and factors associated with belief in COVID-19 vaccine efficacy in Indonesia: A cross-sectional study. Asian Pac J Trop Med 2022; 15(7):308-313.

[12] Rehan HS, Sah RK, Chopra D. Comparison of knowledge, attitude and practices of resident doctors and nurses on adverse drug reaction monitoring and reporting in a tertiary care hospital. Indian J Pharmacol 2012; 44:699-703.

[13] Ogunyemi RA, Odusanya OO. A survey of knowledge and reporting practices of primary healthcare workers on adverse experiences following immunisation in alimosho local government area, Lagos. Niger Postgrad Med J 2016; 23:79-85.

[14] John LJ, Arifulla M, Cheriathu JJ, Sreedharan J. Reporting of adverse drug reactions: An exploratory study among nurses in a teaching hospital, Ajman, United Arab Emirates. DARU J Pharm Sci 2012; 20:44.

[15] Masuka JT, Khoza S. Adverse events following immunisation (AEFI) reports from the Zimbabwe expanded programme on immunisation (ZEPI): An analysis of spontaneous reports in Vigibase(R) from 1997 to 2017. BMC Public Health 2019; 19:1166.

[16] Gurnani V, Haldar P, Aggarwal MK, Das MK, Chauhan A, Murray J, et al. Improving vaccination coverage in India: Lessons from Intensified Mission Indradhanush, a cross-sectoral systems strengthening strategy. BMJ 2018; doi: https://doi.org/10.1136/bmj.k4782.

[17] Masika CW, Atieli H, Were T. Knowledge, perceptions, and practice of nurses on surveillance of adverse events following childhood immunization in Nairobi, Kenya. BioMed Res Int 2016; 2016:3745298.

[18] Mehmeti I, Nelaj E, Simaku A, Tomini E, Bino S. Knowledge, practice and approaches of health professionals to adverse events following immunization and their reporting in Albania. Heliyon 2017; 3:e00331.

[19] Meranus D, Stergachis A, Arnold J, Duchin J. Assessing vaccine safety communication with healthcare providers in a large urban county. Pharmacoepidemiol Drug Safety 2012; 21:269-275.

[20] Parrella A, Braunack-Mayer A, Gold M, Marshall H, Baghurst P. Healthcare providers' knowledge, experience and challenges of reporting adverse events following immunisation: A qualitative study. BMC Health Services Res 2013; 13:313.

[21] Clothier HJ, Lawrie J, Lewis G, Russell M, Crawford NW, Buttery JP. SAEFVIC: Surveillance of adverse events following immunisation (AEFI) in Victoria, Australia, 2018. Commun Dis Intell 2020; doi: 10.33321/cdi.2020.44.46.

[22] Preshaw A. Anaphylactic reactions following vaccination. Aust Vet J 2002; 80:127.

[23] World Health Organization. WHO consultation on global monitoring of adverse events following immunization, 9-10 January 2006=Consultation OMS sur la surveillance mondiale des manifestations postvaccinales indésirables, 9 et 10 janvier 2006. Weekly Epidemiological Record=Relevé épidémiologique hebdomadaire 2006; 81(27):261-265.