Originally discovered in 1965 in Maharashtra, India, the Chandipura virus has become a serious hazard to public health, especially in rural areas. Acute encephalitis syndrome, which mostly affects children and has a high death rate, has been associated with Chandipura virus, an arbovirus largely spread by sandflies ( Phlebotomus spp.). The virus was first thought to be a benign infection, but after many fatal outbreaks, most notably in Gujarat (2005 and 2024) and Andhra Pradesh (2003), it has come to light. The aggressiveness of the virus is highlighted by the quick development from fever to severe neurological symptoms, such as seizures and coma. Public health initiatives concentrate on vector management and supportive care because there is no particular antiviral medication or vaccine available. Recently, Gujrat has witnessed the biggest outbreak of Chandipura virus in 2024 and it may become a big health concern. This paper discusses about Chandipura virus and its recent cases. The virus’s propagation, which is made worse by climate change, makes future outbreaks of the virus more likely. The epidemiology, transmission, and clinical consequences of Chandipura virus are highlighted in this review, along with the necessity of more research, monitoring, and public health readiness to lessen its effects.
Conflict of interest statement
The authors declare that there is no conflict of interest.
Funding
The authors received no extramural funding for the study.
Data availability statement
The data supporting the findings of this study are available from the corresponding authors upon request.
Authors’ contributions
RD conceptualized and designed the work, carried out data collection, and drafted the article. PAC performed data analysis and interpretation, critically reviewed the article, and was responsible for final approval of the version to be published.
| [1] |
Verma AK, Ghosh S, Pradhan S, Basu A. Microglial activation induces neuronal death in Chandipura virus infection. Sci Rep 2016; 6(1). doi: 10.1038/srep22544.
|
| [2] |
John TJ. Chandipura virus-what we know & do not know. Indian J Med Sci 2010; 132(2): 125-127.
|
| [3] |
Menghani S, Chikhale R, Raval A, Wadibhasme P, Khedekar P. Chandipura virus: An emerging tropical pathogen. Acta Trop 2012; 124(1): 1-4.
|
| [4] |
Behera JK, Mishra P, Jena AK, Behera B, Bhattacharya M. Human health implications of emerging diseases and the current situation in India’s vaccine industry. Sci One Health 2023; 2. doi: 10.1016/j.soh.2023.100046.
|
| [5] |
Chadha MS, Arankalle VA, Jadi RS, Joshi MV, Thakare JP, Mahadev PV, et al. An outbreak of Chandipura virus encephalitis in the eastern districts of Gujarat state, India. Am J Trop Med Hyg 2005; 73(3): 566-570.
|
| [6] |
Singh AK, Kumar A, Dhole TN. Recent trends and changing aetiology of acute encephalitis syndrome in India. Morb Mortal 2020; 4: 5.
|
| [7] |
Damle RG, Sankararaman V, Bhide VS, Mahamuni SA, Walimbe AM, Cherian SS. Genetic characterization of the glycoprotein G of Chandipura viruses in India with emphasis on an outbreak of 2015. Infect Genet Evol 2017; 55: 112-116.
|
| [8] |
Jancarova M, Polanska N, Volf P, Dvorak V. The role of sand flies as vectors of viruses other than phleboviruses. J Gen Virol 2023; 104(4). doi: 10.1099/jgv.0.001837.
|
| [9] |
Broor S, Devi LS. Arboviral infections in India. Indian J Med Sci 2015; 2(3): 192-202.
|
| [10] |
Sudeep AB, Bondre VP, Gurav YK, Gokhale MD, Sapkal GN, Mavale MS, et al. Isolation of Chandipura virus (Vesiculovirus: Rhabdoviridae) from Sergentomyia: Species of sandflies from Nagpur, Maharashtra, India. Indian J Med Res 2014; 139(5): 769-772.
|
| [11] |
Sapkal GN, Sawant PM, Mourya DT. Chandipura viral encephalitis: A brief review. Open Virol J 2018; 12: 44-51.
|
| [12] |
Mani RS, Ravi V, Desai A, Madhusudana SN. Emerging viral infections in India. Proc Natl Acad Sci India Sect B Biol Sci 2012; 82: 5-21.
|
| [13] |
Mishra AC. Chandipura encephalitis: A newly recognized disease of public health importance in India. Emerg Infect 2006. doi: 10.1128/9781555815585.ch7.
|
| [14] |
Sudeep AB, Gunjikar RS, Ghodke YS, Khutwad K, Sapkal GN. Temperature sensitivity and environmental stability of Chandipura virus. Virusdisease 2019; 30: 214-218.
|
| [15] |
Dhoundiyal A, Choudhary S, Dikid T, Aswal P, Sharma RP, Goel S. Investigation of a cluster of acute-onset seizures and deaths among children, Sirohi District, Rajasthan, April 2022. Global Biosecur 2023; 5(1). doi: 10.31646/gbio.233.
|
| [16] |
Ghosh S, Dutta K, Basu A. Chandipura virus induces neuronal death through Fas-mediated extrinsic apoptotic pathway. J Virol 2013; 87(22): 12398-12406.
|
| [17] |
Letchworth GJ, Rodriguez LL, Del Cbarrera J. Vesicular stomatitis. Vet J 1999; 157(3): 239-260.
|
| [18] |
Banerjee I, Robinson J, Roy B, Upreti D, Singh AP, Banerjee I. Chandipura virus outbreak in India: A tropical nightmare. J Biomed Sci 2024; 11(1): 4-6.
|
| [19] |
Tripathy A, Balaji S, Rao N, Thakare J, Mishra A, Arankalle V. Cytokine levels in Chandipura virus associated encephalopathy in children. Scand J Infect Dis 2005; 37(8): 590-593.
|
| [20] |
Handique SK, Barthakur M. Tropical viral CNS infections. In: García-Moncó JS (ed.) CNS infections: A clinical approach. Switzerland: Springer Nature; 2018, p. 87-128.
|
| [21] |
Ghosh S, Basu A. Neuropathogenesis by Chandipura virus: An acute encephalitis syndrome in India. Natl Med J India 2017; 30(1): 21-25.
|
| [22] |
Reisen WK. Vector transmission of animal viruses. In: Mahy BWJ, van Regenmortel MHV (eds.) Desk encyclopedia of animal and bacterial virology. USA: Academic Press; 2009, p. 231.
|
| [23] |
Xing Y, Zhang Q, Jiu Y. Coronavirus and the cytoskeleton of virus-infected cells. In: Vijayakrishnan S, Jiu Y, Robin Harris J (eds.) Virus infected cells. Cham: Springer International Publishing; 2023, p. 333-364.
|
| [24] |
Kumar K, Rana J, Sreejith R, Gabrani R, Sharma SK, Gupta A, et al. Intraviral protein interactions of Chandipura virus. Arch Virol 2012; 157: 1949-1957.
|
| [25] |
Van Ranst M. Chandipura virus: An emerging human pathogen? Lancet 2004; 364(9437): 821-822.
|
| [26] |
Dwibedi B, Sabat J, Hazra RK, Kumar A, Dinesh DS, Kar SK. Chandipura virus infection causing encephalitis in a tribal population of Odisha in eastern India. Natl Med J India 2015; 28(4): 185-187.
|
| [27] |
Anukumar B, Shahir P. Chandipura Virus infection in mice: The role of toll like receptor 4 in pathogenesis. BMC Infect Dis 2012; 12: 1-9.
|
| [28] |
Venkateswarlu CH, Arankalle VA. Recombinant glycoprotein based vaccine for Chandipura virus infection. Vaccine 2009; 27(21): 2845-2850.
|
| [30] |
Nimje SN. India is going through its biggest Chandipura virus outbreak in 20 years. [Online] Available from: https://www.business-standard.com/health/india-is-going-through-its-biggest-chandipura-virus-outbreak-in-20-years-124080801506_1.html [Accessed on 9 August 2024].
|
| [31] |
Chandipura virus outbreak: Surge in cases continues! 51 of 53 cases reported in India from Gujarat. [Online] Available from: https://www.financialexpress.com/life/chandipura-virus-outbreak-surge-in-cases-continues-51-of-53-cases-reported-in-india-from-gujarat-3576254/ [Accessed on 10 August 2024].
|
| [32] |
Chandipura virus Centre says 53 cases, 19 deaths reported in the country so far. [Online] Available from: https://www.thehindu.com/sci-tech/health/chandipura-virus-centre-says-53-cases-19-deaths-reported-in-the-country-so-far/article68492102.ece [Accessed on 10 August 2024].
|
| [33] |
Socha W, Kwasnik M, Larska M, Rola J, Rozek W. Vector-borne viral diseases as a current threat for human and animal health-One health perspective. J Clin Med 2022; 11(11): 3026.
|
| [34] |
Zhang JS, Li ZH, Lu JH, Chen ZL. Enhancing vaccination of key populations: Lessons and actions. One Health Bull 2022; 2: 16. doi: 10.4103/2773-0344.361972.
|
| [36] |
Shah HK, Fathima PA, Kumar NP, Kumar A, Saini P. Faunal richness and checklist of sandflies (Diptera: Psychodidae) in India. Asian Pac J Trop Med 2023; 16(5): 193-203.
|