Geraniol alleviates cyclophosphamide-induced cardiotoxicity in mice

Abstract

Objective: To explore the effect of geraniol on cyclophosphamide-induced cardiotoxicity. Methods: Mice were divided into five groups: the control group, the cyclophosphamide group (200 mg/kg cyclophosphamide, i.p. on day 7), the group treated with geraniol 100 and 200 mg/kg from day 1 to day 14, along with a single dose of cyclophosphamide on day 7, and the geraniol alone group (200 mg/kg geraniol from day 1 to day 14). At the end of the study, animals were sacrificed, and blood and heart were collected and analyzed for biochemical, histopathological, and immunohistochemical changes. Results: Treatment with 200 mg/kg geraniol significantly reduced the levels of cardiac injury markers, malondialdehyde, and inflammatory and apoptotic markers, while increasing antioxidant activities in mice with cyclophosphamide-induced cardiotoxicity. Moreover, it remarkably alleviated histopathological aberrations in cardiac tissue. Conclusions: Geraniol attenuates cyclophosphamide-induced cardiotoxicity via antioxidant, anti-inflammatory, and antiapoptotic effects.

Keywords

Geraniol / Cardiotoxicity / Natural product / Cyclophosphamide / Inflammation / Apoptosis

Conflict of interest statement

The authors declare that they have no conflict of interest.

Funding

The Deanship of Scientific Research at King Abdulaziz University, Jeddah, Saudi Arabia has funded this project under grant no. RG-21-166-43.

Data availability statement

The data supporting the findings of this study are available from the corresponding authors upon request.

Authors’ contributions

Conception or design of the work was done by SK. Investigation and data collection were done by RAS. SK and RAS contributed to interpretation. RAS was involved in writing original draft and preparation. Critical revision of the article and final approval of the version to be published were done by SK.

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