Therapeutic effects of Coriandrum sativum extracts: A review

Abstract

Medicinal plants, as a good therapeutic strategy, can be used to treat a wide spectrum of diseases. Coriandrum sativum ( C. sativum) is a plant from Apiaceae family. Numerous reports indicate that C. sativum has positive effects on anxiety, seizure, learning and memory ability, as well as pain. This annual plant can also treat colitis, increase appetite, reduce blood pressure, and attenuate myocardial damage. Additionally, it improves liver and kidney function and diabetes mellitus and inhibits osteoclast activity. These beneficial effects of C. sativum mainly are attributed to its antioxidant and anti-inflammatory properties. The present paper reviews the impacts of C. sativum on different body systems. Information was extracted by searching the Web of Science, PubMed, Scopus, and Google Scholar from January 2010 until the end of February 2024.

Keywords

Coriandrum sativum / Inflammation / Antioxidant / Oxidative stress / Nervous system / Liver

Conflict of interest statement

The author declares that there is no conflict of interest.

Funding

The study received no extramural funding.

Data availability statement

The data supporting the findings of this study are available from the corresponding authors upon request.

References

[1] Guo M, Qin S, Wang S, Sun M, Yang H, Wang X, et al. Herbal medicine nanocrystals: A potential novel therapeutic strategy. Molecules 2023; 28(17). doi: 10.3390/molecules28176370.

[2] Anaeigoudari F, Anaeigoudari A, Kheirkhah-Vakilabad A. A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents. Physiol Rep 2023; 11(15). doi: 10.14814/phy2.15785.

[3] Pang GM, Li FX, Yan Y, Zhang Y, Kong LL, Zhu P, et al. Herbal medicine in the treatment of patients with type 2 diabetes mellitus. Chin Med J 2019; 132(1): 78-85.

[4] Pourali G, Hosseini ZS, Maftooh M, Nazari E, Khazaei M, Nassiri M, et al. Therapeutic potential of herbal medicine against non-alcoholic fatty liver disease. Curr Drug Targets 2023; 24(4): 300-319.

[5] Al-Khayri JM, Banadka A, Nandhini M, Nagella P, Al-Mssallem MQ, Alessa FM. Essential oil from Coriandrum sativum: A review on its phytochemistry and biological activity . Molecules 2023; 28(2). doi: 10.3390/molecules28020696.

[6] Hosseini M, Boskabady MH, Khazdair MR. Neuroprotective effects of Coriandrum sativum and its constituent, linalool: A review . Avicenna J Phytomed 2021; 11(5): 436-450.

[7] Sahib NG, Anwar F, Gilani AH, Hamid AA, Saari N, Alkharfy KM. Coriander (Coriandrum sativum L.): A potential source of high-value components for functional foods and nutraceuticals-A review . Phytother Res 2013; 27(10): 1439-1456.

[8] Bhat S, Kaushal P, Kaur M, Sharma H. Coriander (Coriandrum sativum L.): Processing, nutritional and functional aspects . Afr J Plant Sci 2014; 8(1): 25-33.

[9] Said AA, Reda RM, Metwally MM, El-Hady HMA. The contribution of Coriandrum sativum in enhancing Oreochromis niloticus rearing at sub-optimal temperatures: Effect on growth, health status, survival rate, and resistance to Aeromons veronii . BMC Vet Res 2023; 19(1): 254. doi: 10.1186/s12917-023-03809-8.

[10] Khazdair MR, Anaeigoudari A, Gabriel AA. Anti-viral and anti-inflammatory effects of kaempferol and quercetin and COVID-2019: A scoping review. Asian Pac J Trop Biomed 2021; 11(8): 327-334.

[11] Harsha S, Anilakumar K. In vitro free radical scavenging and DNA damage protective property of Coriandrum sativum L. leaves extract . J Food Sci Technol 2014; 51: 1533-1539.

[12] S’hih Y, Hinad I, Gui RE, Elhessni A, Mesfioui A, Loukili A, et al. Evaluation of the acute and subacute toxicity of aqueous extract of Coriandrum sativum L. seeds in Wistar rats . Curr Drug Saf 2023; 18(4): 504-510.

[13] Aissaoui A, Zizi S, Israili ZH, Lyoussi B. Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats . J Ethnopharmacol 2011; 137(1): 652-661.

[14] Ashraf A, Zafar S, Zahid K, Shah MS, Al-Ghanim KA, Al-Misned F, et al. Synthesis, characterization, and antibacterial potential of silver nanoparticles synthesized from Coriandrum sativum L. J Infect Public Health 2019; 12(2): 275-281.

[15] Băieş MH, Cotuţiu VD, Spînu M, Mathe A, Cozma-Petruț A, Miere D, et al. The effects of Coriandrum sativum L. and Cucurbita pepo L. against gastrointestinal parasites in swine: An in vivo study . Microorganisms 2023; 11(5). doi: 10.3390/microorganisms11051230.

[16] Jiao Y, Wang X, Chen JH. Biofabrication of AuNPs using Coriandrum sativum leaf extract and their antioxidant, analgesic activity . Sci Total Environ 2021; 767. doi: 10.1016/j.scitotenv.2020.144914.

[17] Sobhani Z, Mohtashami L, Amiri MS, Ramezani M, Emami SA, Simal-Gandara J. Ethnobotanical and phytochemical aspects of the edible herb Coriandrum sativum L. J Food Sci 2022; 87(4): 1386-1422.

[18] Saeki N, Tamano H, Takeuchi A, Katahira M, Nishio R, Tamura H, et al. Heated leaf extract of Coriandrum sativum L. protects nigral dopaminergic degeneration in rats . Plant Foods Hum Nutr 2022; 77(3): 455-459.

[19] Kumar A, Kumar V, Akhouri V, Kumar R, Ali M, Rashmi T, et al. Protective efficacy of Coriandrum sativum seeds against arsenic induced toxicity in Swiss albino mice . Toxicol Res 2022; 38(4): 437-447.

[20] Tousson E, Shalaby SY, El-Gharbawy DM, Akela MA, Rabea M, Kandil EH. Impact of Coriandrum sativum seeds extract on albino rats’ testicular toxicity caused by carbendazim . Toxicol Res 2023; 12(6): 1152-1158.

[21] Salem MA, Manaa EG, Osama N, Aborehab NM, Ragab MF, Haggag YA, et al. Coriander (Coriandrum sativum L.) essential oil and oil-loaded nano-formulations as an anti-aging potentiality via TGFβ/SMAD pathway . Sci Rep 2022; 12(1): 6578. doi: 10.1038/s41598-022-10494-4.

[22] Elmas L, Secme M, Mammadov R, Fahrioglu U, Dodurga Y. The determination of the potential anticancer effects of Coriandrum sativum in PC-3 and LNCaP prostate cancer cell lines . J Cell Biochem 2019; 120(3): 3506-3513.

[23] Misrani A, Tabassum S, Wang T, Huang H, Jiang J, Diao H, et al. Vibration-reduced anxiety-like behavior relies on ameliorating abnormalities of the somatosensory cortex and medial prefrontal cortex. Neural Regen Res 2024; 19(6): 1351-1359.

[24] Robinson OJ, Pike AC, Cornwell B, Grillon C. The translational neural circuitry of anxiety. J Neurol Neurosurg Psychiatry 2019; 90(12): 1353-1360.

[25] Arab Z, Hosseini M, Mashayekhi F, Anaeigoudari A. Zataria multiflora extract reverses lipopolysaccharide-induced anxiety and depression behaviors in rats . Avicenna J Phytomed 2020; 10(1): 78-88.

[26] Mahendra P, Bisht S. Anti-anxiety activity of Coriandrum sativum assessed using different experimental anxiety models . Indian J Pharmacol 2011; 43(5): 574-577.

[27] Latha K, Rammohan B, Sunanda B, Maheswari MU, Mohan SK. Evaluation of anxiolytic activity of aqueous extract of Coriandrum sativum Linn. in mice: A preliminary experimental study . Pharmacognosy Res 2015; 7(1): S47-S51.

[28] Zenki KC, Souza LSd, Góis AM, Lima BdS, Araújo AAdS, Vieira JS, et al. Coriandrum sativum extract prevents alarm substance-induced fear-and anxiety-like responses in adult zebrafish . Zebrafish 2020; 17(2): 120-130.

[29] Shen CH, Fang GL, Yang F, Cai MT, Zheng Y, Fang W, et al. Seizures and risk of epilepsy in anti-NMDAR, anti-LGI1, and anti-GABABR encephalitis. Ann Clin Transl Neurol 2020; 7(8): 1392-1399.

[30] Asgharzadeh F, Hosseini M, Bargi R, Soukhtanloo M, Beheshti F, Mohammady Z, et al. Effect of captopril on brain oxidative damage in pentylenetetrazole-induced seizures in mice. Pharm Sci 2019; 25(3): 221-226.

[31] Anaeigoudari A, Hosseini M, Karami R, Vafaee F, Mohammadpour T, Ghorbani A, et al. The effects of different fractions of Coriandrum sativum on pentylenetetrazole-induced seizures and brain tissues oxidative damage in rats . Avicenna J Phytomed 2016; 6(2): 223-235.

[32] Karami R, Hosseini M, Mohammadpour T, Ghorbani A, Sadeghnia HR, Rakhshandeh H, et al. Effects of hydroalcoholic extract of Coriandrum sativum on oxidative damage in pentylenetetrazole-induced seizures in rats . Iran J Neuro 2015; 14(2): 59-66.

[33] Pourzaki M, Homayoun M, Sadeghi S, Seghatoleslam M, Hosseini M, Bideskan AE. Preventive effect of Coriandrum sativum on neuronal damages in pentylentetrazole-induced seizure in rats . Avicenna J Phytomed 2017; 7(2): 116-128.

[34] Koppula S, Choi DK. Anti-stress and Anti-amnesic effects of Coriandrum sativum Linn (Umbelliferae) extract - an experimental study in rats . Trop J Pharm Res 2012; 11(1): 36-42.

[35] Mima Y, Izumo N, Chen JR, Yang SC, Furukawa M, Watanabe Y. Effects of Coriandrum sativum seed extract on aging-induced memory impairment in Samp8 mice . Nutrients 2020; 12(2). doi: 10.3390/nu12020455.

[36] Zargar-Nattaj SS, Tayyebi P, Zangoori V, Moghadamnia Y, Roodgari H, Jorsaraei SG, et al. The effect of Coriandrum sativum seed extract on the learning of newborn mice by electric shock: Interaction with caffeine and diazepam . Psychol Res Behav Manag 2011; 4: 13-19.

[37] Koppula S, Alluri R, Kopalli SR. Coriandrum sativum attenuates microglia mediated neuroinflammation and MPTP-induced behavioral and oxidative changes in Parkinson’s disease mouse model . EXCLI J 2021; 20: 835-850.

[38] Kajal A, Singh R. Coriandrum sativum improve neuronal function via inhibition of oxidative/nitrosative stress and TNF-α in diabetic neuropathic rats . J Ethnopharmacol 2020; 263. doi: 10.1016/j.jep.2020.112959.

[39] Begnami AF, Spindola HM, Ruiz ALTG, de Carvalho JE, Groppo FC, Rehder VLG. Antinociceptive and anti-edema properties of the ethyl acetate fraction obtained from extracts of Coriandrum sativum Linn. leaves . Biomed Pharmacother 2018; 103: 1617-1622.

[40] Anaeigoudari A. Hepato-and reno-protective effects of thymoquinone, crocin, and carvacrol: A comprehensive review. Asian Pac J Trop Biomed 2022; 12(5): 185-196.

[41] Marefati N, Beheshti F, Etemadizadeh P, Hosseini M, Anaeigoudari A. Gum resin extract of Boswellia serrata attenuates lipopolysaccharide-induced inflammation and oxidative damage in hepatic and renal tissues of rats . Asian Pac J Trop Biomed 2022; 12(1): 20-25.

[42] Pandey A, Bigoniya P, Raj V, Patel K. Pharmacological screening of Coriandrum sativum Linn. for hepatoprotective activity . J Pharm Bioallied Sci 2011; 3(3): 435-441.

[43] Sfar M, Souid G, Alminderej FM, Mzoughi Z, El-Ghoul Y, Rihouey C, et al. Structural characterization of polysaccharides from Coriandrum sativum seeds: Hepatoprotective effect against cadmium toxicity in vivo . Antioxidants 2023; 12(2). doi: 10.3390/antiox12020455.

[44] Kükner A, Toros P, Söyler G, Isik S, Ögütçü G, Edebal O, et al. Effects of Coriandrum sativum on distant organ inflammation and apoptosis due to liver ischemia/reperfusion injury . Rom J Morphol Embryol 2023; 64(2): 207-213.

[45] Moustafa AHA, Ali EMM, Moselhey SS, Tousson E, El-Said KS. Effect of coriander on thioacetamide-induced hepatotoxicity in rats. Toxicol Ind Health 2014; 30(7): 621-629.

[46] Kwon SJ, Khan MS, Kim SG. Intestinal inflammation and regeneration-interdigitating processes controlled by dietary lipids in inflammatory bowel disease. Int J Mol Sci 2024; 25(2). doi: 10.3390/ijms25021311.

[47] Mogilevski T, Nguyen AL, Ajamian M, Smith R, Rosella S, Sparrow MP, et al. Intestinal barrier biomarkers in clinical evaluation of patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol 2024; 36(3): 271-280.

[48] Heidari B, Sajjadi SE, Minaiyan M. Effect of Coriandrum sativum hydroalcoholic extract and its essential oil on acetic acid-induced acute colitis in rats . Avicenna J Phytomed 2016; 6(2): 205-214.

[49] Nematy M, Kamgar M, Mohajeri SMR, Zadeh SAT, Jomezadeh MR, Hasani OA, et al. The effect of hydroalcoholic extract of Coriandrum sativum on rat appetite . Avicenna J Phytomed 2013; 3(1): 91-97.

[50] Buja LM, Ottaviani G, Mitchell RN. Pathobiology of cardiovascular diseases: An update. Cardiovasc Pathol 2019; 42: 44-53.

[51] Gencheva DG, Nikolov FP, Uchikova EH, Hristova KA, Mihaylov RD, Pencheva BG. Hypertension in pregnancy as an early sex-specific risk factor for cardiovascular diseases: Evidence and awareness. Folia Med 2022; 64(3): 380-387.

[52] Rehman K, Fatima F, Waheed I, Akash MSH. Prevalence of exposure of heavy metals and their impact on health consequences. J Cell Biochem 2018; 119(1): 157-184.

[53] Rana R, Mehmood MH, Shaukat B, Shahid S, Malik A, Murtaza B. Evaluation of the cardiovascular effects of Coriandrum sativum and Citrus limon to treat arsenic-induced endothelial damage and hypertension in rats . Life 2022; 12(11). doi: 10.3390/life12111842.

[54] Wang X, Liu Y, Wang Y, Dong X, Wang Y, Yang X, et al. Protective effect of Coriander (Coriandrum sativum L.) on high-fructose and high-salt diet-induced hypertension: Relevant to improvement of renal and intestinal function . J Agric Food Chem 2022; 70(12): 3730-3744.

[55] Patel DK, Desai SN, Gandhi HP, Devkar RV, Ramachandran A. Cardio protective effect of Coriandrum sativum L. on isoproterenol induced myocardial necrosis in rats . Food Chem Toxicol 2012; 50(9): 3120-3125.

[56] Dhyani N, Parveen A, Siddiqi A, Hussain ME, Fahim M. Cardioprotective efficacy of Coriandrum sativum [L.] seed extract in heart failure rats through modulation of endothelin receptors and antioxidant potential . J Diet Suppl 2020; 17(1): 13-26.

[57] Lee JH, Yi H, Lee JH, Seo HW, Oh KS, Lee BH. KR-31831 improves survival and protects hematopoietic cells and radiosensitive tissues against radiation-induced injuries in mice. Biomed Pharmacother 2022; 146. doi: 10.1016/j.biopha.2021.112350.

[58] Shao L, Li H, Pazhanisamy SK, Meng A, Wang Y, Zhou D. Reactive oxygen species and hematopoietic stem cell senescence. Int J Hematol 2011; 94: 24-32.

[59] Han X, Xue X, Zhao Y, Li Y, Liu W, Zhang J, et al. Rutin-enriched extract from Coriandrum sativum L. ameliorates ionizing radiation-induced hematopoietic injury . Int J Mol Sci 2017; 18(5). doi: 10.3390/ijms18050942.

[60] Sulaiman RA. Inherited metabolic disorders and dyslipidaemia. J Clin Pathol 2020; 73(7): 384-390.

[61] Aron-Wisnewsky J, Warmbrunn MV, Nieuwdorp M, Clément K. Metabolism and metabolic disorders and the microbiome: The intestinal microbiota associated with obesity, lipid metabolism, and metabolic health-pathophysiology and therapeutic strategies. Gastroenterology 2021; 160(2): 573-599.

[62] Hameed I, Masoodi SR, Mir SA, Nabi M, Ghazanfar K, Ganai BA. Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition. World J Diabetes 2015; 6(4): 598-612.

[63] McCracken E, Monaghan M, Sreenivasan S. Pathophysiology of the metabolic syndrome. Clin Dermatol 2018; 36(1): 14-20.

[64] Thomas MS, Calle M, Fernandez ML. Healthy plant-based diets improve dyslipidemias, insulin resistance, and inflammation in metabolic syndrome. A narrative review. Adv Nutr 2023; 14(1): 44-54.

[65] Tseng PL, Chung TL, Lee CH. Association of metabolic syndrome and other factors with the presence of diabetic nephropathy in type 2 diabetic patients. Int J Environ Res Public Health 2023; 20(3). doi: 10.3390/ijerph20032453.

[66] Yasir M, Senthilkumar GP, Jayashree K, Ramesh Babu K, Vadivelan M, Palanivel C. Association of serum omentin-1, apelin and chemerin concentrations with the presence and severity of diabetic retinopathy in type 2 diabetes mellitus patients. Arch Physiol Biochem 2022; 128(2): 313-320.

[67] Yella SST, Kumar RN, Ayyanna C, Varghese AM, Amaravathi P, Vangoori Y. The combined effect of Trigonella foenum seeds and Coriandrum sativum leaf extracts in alloxan-induced diabetes mellitus Wistar albino rats . Bioinformation 2019; 15(10): 716-722.

[68] Attaallah A, Elmrazeky AR, El-Beltagy AEFB, Abdelaziz KK, Soliman MF. Modulatory role of Coriandrum sativum [coriander] extract against diabetic complications on the gonads of female rats and their offspring . Tissue Cell 2023; 83. doi: 10.1016/j.tice.2023.102127.

[69] Kajal A, Singh R. Coriandrum sativum seeds extract mitigate progression of diabetic nephropathy in experimental rats via AGEs inhibition . PLoS One 2019; 14(3). doi: 10.1371/journal.pone.0213147.

[70] Mechchate H, Es-Safi I, Amaghnouje A, Boukhira S, Alotaibi AA, Al-Zharani M, et al. Antioxidant, anti-Inflammatory and antidiabetic proprieties of LC-MS/MS identified polyphenols from Coriander seeds. Molecules 2021; 26(2). doi: 10.3390/molecules26020487.

[71] Lakhera A, Ganeshpurkar AG, Bansal D, Dubey N. Chemopreventive role of Coriandrum sativum against gentamicin-induced renal histopathological damage in rats . Interdiscip Toxicol 2015; 8(2): 99-102.

[72] Sim JS, Lee HY, Yim M. Anti-osteoclastogenic effects of Coriandrum sativum L. via the NF‑κB and ERK‑mediated NFATc1 signaling pathways . Mol Med Rep 2022; 26(5): 333. doi: 10.3892/mmr.2022.12849.