Anti-inflammatory and anti-cancer potential of pterostilbene: A review

Abstract

Pterostilbene is a natural compound that can be found in various food plants such as blueberries, grapes, and peanuts. It has also been reported to be extracted from Pterocarpus indicus, a tree species native to India and Southeast Asia. Pterostilbene exhibits various pharmacological activities such as antioxidants, anti-proliferation, anti-microbial, and anti-inflammatory activities with favorable pharmacokinetic properties, such as high oral bioavailability and longer half-life. The anti-inflammatory effect of pterostilbene has been reported to contribute to its therapeutic effects in many chronic inflammatory diseases. Besides, pterostilbene has anti-cancer activity on various types of cancers due to its ability to induce cell cycle arrest and apoptosis. Hence, in this review, we discuss the anti-inflammatory and anti-cancer activities of pterostilbene in preclinical studies.

Keywords

Pterostilbene / Anti-cancer / NF-κB / Anti-inflammation / Natural product / Pterocarpus indicus

Conflict of interest statement

The authors declare no conflict of interest.

Funding

This review received funding from the Ministry of Higher Education (MOHE) Malaysia through the Fundamental Research Grant Scheme (FRGS) with grant number: FRGS/1/2019/SKK10/UKM/01/1.

Data availability statement

The data supporting the findings of this study are available from the corresponding authors upon request.

Authors’ contributions

All authors contributed to the idea of this review. OS contributed to the draft and writing of this review. SFM and DFB contributed to the writing and proofreading. ARG contributed to the writing, proofreading, and funding acquisition.

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