Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats

Abstract

Objective: To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in rats. Methods: Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 days. Hematological, biochemical, electrocardiography, echocardiography, and histopathological examinations were performed. Results: Hesperidin decreased the neutrophil-to-lymphocyte ratio, calcium, creatine kinase-myoglobin binding, lactate dehydrogenase, IL-6, and lipid peroxidation, as well as increased sodium and potassium concentration and superoxide dismutase and catalase activity in arsenic trioxide-intoxicated rats. Moreover, it reduced peak systolic velocity and end-diastolic velocity while increasing heart rate. Arsenic trioxide-induced histopathological damage to cardiac tissue was prominently alleviated by hesperidin treatment. Conclusions: Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats. Therefore, it can be further explored as a cardioprotective agent.

Keywords

Arsenic trioxide / Hesperidin / Cardiotoxicity / ECG / CK-MB / LDH

Conflict of interest statement

The authors have no conflict of interest to declare.

Funding

The authors received no extramural funding for the study.

Authors’ contributions

GK and JRD designed the experiment and analyzed the result. BJ performed echocardiography. UM performed histopathology and SP analyzed the results.

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