Effect of two doses of coenzyme Q10 on spermogram parameters, sperm chromatin integrity and partner pregnancy rate in men with idiopathic oligoasthenozoospermia: A prospective study

Abstract

Objective: To evaluate the effectiveness of two doses of coenzyme Q10 (CoQ10) on semen parameters, sperm DNA damage, and the partner pregnancy rate in men with idiopathic oligoasthenozoospermia.
Methods: 250 patients with idiopathic oligoasthenozoospermia were examined. The first group (n=125) received 100 mg/day of CoQ10 and the second group (n=125) received 200 mg/day of CoQ10 orally for 6 months. Semen parameters, DNA fragmentation index (DFI) and the partner pregnancy rate were analyzed at baseline and after 6 months of treatment.
Results: Comparing with baseline data, treatment with CoQ10 (100 mg/day or 200 mg/day) resulted in a significant increase in sperm concentration (both P<0.001), a significant improvement in progressive motility and total motile sperm count (P=0.05, P=0.001, respectively). The mean DFT was significantly improved after treatment with CoQ10 at 100 mg/day and at 200 mg/day, after 6 months of treatment (P<0.01). Moreover, CoQ10 significantly improved the partner pregnancy rate. A strongest correlation was found between seminal fluid parameters and DFI (P<0.001).
Conclusions: CoQ10 is effective in improving semen parameters, DFI and on the partner pregnancy rate after 6 months with CoQ10 at two doses, with a greater improvement shown in men who took 200 mg/day than in those who took 100 mg/day.

Keywords

Antioxidants / Coenzyme Q10 / Oxidative stress / Idiopathic oligoasthenozoospermia / Male infertility

Conflict of interest statement

The authors have no competing interests to declare.

Acknowledgements

We would like to thank all the collaborators and teams of the assisted human reproduction unit who authorized and facilitated the data’s collection.

Funding

This study receives no extramural funding.

Data availability statement

The data underlying this article will be shared on reasonable request to the corresponding author.

Authors’ contributions

Chaymae Rochdi contributed to concept, acquisition, writing-original draft, methodology, validation, visualization, writing-review & editing, formal analysis, and ressources. Othmane Adli performed methodology, validation, and software. Hafsa Taheri contributed to investigation, acquisition, methodology, and validation. Hanane Saadi contributed to validation, writing-review & editing, formal analysis, and supervision. Ahmed Mimouni contributed to validation, project administration, data curation, supervision, and resources. Mohammed Choukri contributed to writing-review & editing, project administration, data curation, supervision, and resources. All authors have read and approved the final version of the manuscript.

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