Research progress on chemical constituents and pharmacological effects of medicinal plant Scutellaria baicalensis

Abstract

Scutellaria baicalensis (S. baicalensis) is a heat-clearing and moisture-drying medicine, which is used to treat diseases such as warm fever, upper respiratory tract infection, lung heat cough, moist heat jaundice, pneumonia, dysentery, hemoptysis, red eyes, restless fetus, hypertension, abscess, swelling and boils. In recent years, with the in-depth study of its chemical composition and pharmacological activity, it was found that the clinical antibacterial activity of S. baicalensis was significant, and it did not produce drug resistance. The chemical constituents and pharmacological effects of S. baicalensis were reviewed in this paper. This review can provide reference for further development and utilization of medicinal value of S. baicalensis.

Keywords

Scutellaria baicalensis / chemical composition / pharmacological effect

Acknowledgements

This work was financially supported by National Nature Science Foundation of China (81973284) and Scientific Research Foundation of the Education Department of Liaoning Province (LJKZ0944).

References

[1] Maleki S, Akaberi T, Emami SA, et al. Diterpenes of Scutellaria spp.: Phytochemistry and pharmacology. Phytochemistry, 2022, 201: 113285.

[2] Li L, Hao JD. Study on formation and change of Huangqin Road producing area. Shi Zhen Chin Med, 2010, 21: 3290-3292.

[3] Wang R, Shen X, Xing E, et al. Scutellaria baicalensis stem-leaf total flavonoid reduces neuronal apoptosis induced by amyloid beta-peptide (25-35). Neural Regen Res, 2013, 8: 1081-1090.

[4] National Pharmacopoeia Committee. Chinese Pharmacopoeia. Beijing: Chin Med Sci Techn Press, 2025.

[5] Li HB, Jiang Y, Chen F. Separation methods used for Scutellaria baicalensis active components. J chroma B, 2004, 812: 277-290.

[6] Wang ZL, Wang S, Kuang Y, et al. A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis. Pharm Bio, 2018, 56: 465-484.

[7] Song JW, Long J Y, Xie L, et al. Applications, phytochemistry, pharmacological ef fects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review. Chin Med, 2020, 15: 102-105.

[8] Zhang L, Song J, Kong L, et al. The strategies and techniques of drug discovery from natural products. Pharm Ther, 2020, 216: 107686-107695.

[9] Zhou P, Zuo L, Liu C, et al. Unraveling spatial metabolome of the aerial and underground parts of Scutellaria baicalensis by matrix-assisted laser desorption/ionization mass spectrometry imaging. Phytomedicine, 2024, 123: 155259-155264.

[10] Baradaran RV, Askari VR, Hosseinzadeh H. Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: a review. Phytother Res, 2021, 35: 3558-3574.

[11] Arjmandi BH, Ormsbee LT, Elam ML, et al. A combination of Scutellaria baicalensis and Acacia catechu extracts for short-term symptomatic relief of joint discomfort associated with osteoarthritis of the knee. J Med Food, 2014, 17: 707-713.

[12] Shen J, Li P, Liu S, et al. Traditional uses, ten-years research progress on phytochemistry and pharmacology, and clinical studies of the genus Scutellaria. J Ethnopharmacol, 2021, 265: 113198-113204.

[13] Kim JK, Kim YS, Kim YJ, et al. Comparative analysis of flavonoids and polar metabolites from hairyroots of Scutellaria baicalensis and Scutellaria lateriflora. World J Micro Biotech, 2014, 30: 887-892.

[14] Zhang CH, Zhang W, Zhang H, et al. Main composition of baicalin and radix scutellariae radix scutellariae bacteriostatic test in vitro. J Chin Veter Med, 2020, 33: 83-85.

[15] Zhao Q, Cui MY, Levsh O, et al. Two CYP82D enzymesfunction as flavone hydroxylases in the biosynthesis of root-specific 40-deoxyflavones in Scutellaria baicalensis. Molecular Plant, 2018, 11: 135-148.

[16] Xu JX, Ding LQ, Jiang MM, et al. No- flavonoidconstituents from the roots of Scutellaria baicalensis Georgi. Chin J Med Chem, 2016, 26: 480-483.

[17] Luo H, Yu Y, Xiao L, et al. Review on the effects of main chemical components of Scutellaria baicalensis on oral diseases. World Sci Tech Mod Chin Med, 2019, 23: 3289-3297.

[18] Shen J, Li P, Liu S, et al. Traditional uses, ten-years researchprogress on phytochemistry and pharmacology, and clinical studiesof the genus Scutellaria. J Ethnopharmacol, 2021, 265: 113-198.

[19] Lin YP, Fu SN, Wang MM, et al. Chemical constituents fromthe rools of Scutellaria likiangensis. J Chin Trad Patent Med, 2021, 43: 2399-2403.

[20] Alsharairi NA. Scutellaria baicalensis and their natural flavonecompounds as potential medicinal drugs for the treatment of nico-tine-induced non-small-cell lung cancerand asthma. Int J Environ Res Public Health, 2021, 18: 5243-5249.

[21] Guo M, Zhang N, Li D, et al. Baicalin plays an anti- inflammatory role through reducing nuclear factor- kBand p38 phosphorylation in S. aureus-induced mastitis. Int Immunopharmacol, 2013, 16: 125-130.

[22] Rui W, Li S, Xiao H, et al. Baicalein attenuates neuroinflammation by inhibiting NLRP3/caspase-1/ GSDMD pathway in MPTPinduced mice model of Parkinson’s disease. Int J Neuro Chopharm, 2020, 23: 762-773.

[23] Suh MG, Choi H, Cho K, et al. Anti-inflammalory action ofherbal medicine comprised of Scutellaria baicalensis and Chrysanthemum morifolium. Biosci Biotechnol Biochem, 2020, 84: 1799-1809.

[24] Wu S, Sun A, Liu R. Separation and purification of baicalin andwogonoside from the Chinese medicinal plant Seutellaria baicalen-sis Georgi by high-speed counter-current chromatography. J Chrom A, 2005, 1066: 243-247.

[25] Zhang QH, Tan L, Gou Q, et al. 6,8-di-C-glycosyl flavoneswith B-furanoarabinose from Scutellaria baicalensis and their anti-inflammalory activities. Nat Prod Res, 2019, 33: 1243-1250.

[26] Chen K, Wu W, Hou X, et al. A review: antimicrobial properties of several medicinal plants widely used in Traditional Chinese Medicine. Food Qua Safe, 2021, 5: 192-196.

[27] Liu H, Zhao ZB, Wang X. Antimicrobial activity of baicalin to E. coli and relevant mechanism. Chin J Biol, 2019, 32: 983-986.

[28] Bai L, Yang YX, Wan QF, et al. Baicalin alleviates synovitis in rats with rheumatoid arthritis by TLR2/NF- κB pathway. Chin Pharm Bul, 2017, 33: 1569-1573.

[29] Chen YC, Shen SC, Chen LG, et al. Wogonin, baicalin, and baicalein inhibition of inducible nitricoxide synthaseand cyclo oxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochem Pharmacol, 2001, 61: 1417-1427.

[30] Meng L, Zang XW, Li ZL. Apoptosis of human hepatocellular carcinoma HepG-2 cells induced by baicalin and its effect on expression of related protein. When Zhen Chin Med, 2010, 21: 2212-2213.

[31] Xiao WM, Bu P, Gong WJ. Research progress on antitumor and immunomodulatory effects of baicalein. Chin J Tradit Chin Med, 2014, 39: 3004-3009.

[32] Jan AT, Azam M, Siddiqui K, et al. Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants. Inter J Mole Sci, 2015, 16: 29592-29630.

[33] Patil YP, Pawar SH, Jadhav S, et al. Biochemistry of metal absorption in human body: Reference to check impact of nano particles on human being. Int J Sci Res Publ, 2013, 3: 1-5.

[34] Han YK, Kim H, Shin H, et al. Characterization of anti-inflammatory and antioxidan constituents from Scutellaria baicalensis using LC-MS coupled with a bioassay method. Molecules, 2020, 25: 3617.

[35] Cao P, Zhang YS, Wei XM, et al. Research progress on an-tioxidant mechanism of baicalin. West J Tradit Chin Med, 2021, 34: 134-137.

[36] Shi YJ, Liu JY, Yang M. Evaluation on dissolution and antioxidant properties of different extracts of Scutellaria baicalensis. Chin J Exp Form, 2014, 20: 1-4.

[37] Li P, Zhang R, Wang M, et al. Baicalein prevents fructose-induced hepatic steatosis in rals: in the regulation of fatty acid denovo synthesis, falty acid elongation and fatty acid oxidation. Front Pharm, 2022, 13: 917329-917335.

[38] Meng HY, Chang H. Comparison study on inhibitory effects of Scutellariae decoction and baicalin on hepatic fibrosis rats. World Chin Med, 2018, 13: 699-702.

[39] Rao A, Douglas SC, Hall JM. Endocrine Disrupting Chemicals, Hormone Receptors, and Acne Vulgaris: A Connecting Hypothesis. Cells, 2021, 9: 1439-1445.

[40] Bai QY, Tao SM, Tian JH, et al. Progress of research oneffect and mechanism of Scutellariae Radix on preventing liverdiseases. Chin J Chin Mater Med, 2020, 45: 2808-2816.

[41] Song Q, Peng S, Zhu X. Baicalein protects against MPP+/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson’s disease. Neurotoxicology, 2021, 87: 188-194.