Rebalancing hepatic carbohydrate metabolism: Effects of Dalbergiella welwitschii (Baker) Baker f. (Fabaceae) under diabetic conditions

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Abstract

This study evaluated the effects of an alkaloid-rich leaf extract of Dalbergiella welwitschii (Baker) Baker f. on hepatic carbohydrate metabolism in streptozotocin-induced diabetic rats. Diabetes was induced in rats, which were then treated with low (50 mg/kg) and high (100 mg/kg) doses of the extract, or metformin (200 mg/kg), for 20 days. Key hepatic enzymes-glycogen phosphorylase, glucose-6-phosphatase, lactate dehydrogenase, fructose-1,6-bisphosphatase, glycogen synthase, and hexokinase-along with hepatic glycogen and insulin levels were measured. Treatment with the extract significantly restored enzyme activities, increased insulin levels, and enhanced glycogen content. These results indicate that D. welwitschii extract can modulate hepatic carbohydrate metabolism and may have potential therapeutic benefits for diabetes management.

Keywords

alkaloids / diabetes mellitus / hepatic enzymes / phytotherapy / west African blackwood

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