Assessment of bisphenol A in bottled drinking water and its environmental health risk implications

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Abstract

Bisphenol A (BPA) is an industrial chemical commonly used as a monomer or additive in the production of polycarbonate plastics, epoxy resins, and other polymeric materials. BPA contamination is primarily associated with plastic bottled water containers. BPA has been associated with a range of adverse health effects. This study aims to investigate the impact of BPA exposure on public health in relation to the consumption of bottled drinking water. The research was conducted in Tambak Wedi Village, Surabaya, from July to October 2024. A total of 96 respondents participated in this cross-sectional study, which included laboratory analysis of bottled water samples and a human health risk assessment. Among ten brands of bottled water consumed by respondents, Brand A exhibited the highest BPA concentration (maximum 0.099 mg/L), while Brand G showed the lowest (maximum 0.082 mg/L). BPA exposure through bottled water consumption was not found to be significantly associated with carcinogenicity, reproductive system disorders, or endocrine disruption. However, a significant association was observed with immunosuppressive disorders (p-value=0.008; r-value=0,151), with very weak positive correlation strength. The noncarcinogenic and carcinogenic health risks of BPA across all bottled water brands were within acceptable safety limits. Collaborative efforts from governmental bodies, industry stakeholders, and consumers are essential to minimize the potential health risks associated with BPA exposure.

Keywords

Bisphenol A / bottled drinking water / health / environmental health risk analysis

CHANGE HISTORY

A Correction to this paper has been published:
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References

[1] Ministry of Environment and Forestry. Bisfenol A dalam kemasan pangan. Ministry of Environment and Forestry, 2022. Available from: http://sib3pop.menlhk.go.id/index.php/articles/view?slug=bisfenol-a-dalam-kemasan-pangan

[2] CDC. National Biomonitoring Program. Centers for Disease Control and Prevention, 2017. Available from: https://www-cdc-gov.translate.goog/biomonitoring/BisphenolA_FactSheet.html?_x_tr_sl=en&_x_tr_tl=id&_x_tr_hl=id&_x_tr_pto=sc

[3] Indonesian Food and Drug Authority (BPOM). Penjelasan BPOM RI tentang kandungan bisfenol A (BPA) dalam air minum dalam kemasan (AMDK). Indonesian Food and Drug Authority (BPOM), 2021. Available from: https://klubpompi.pom.go.id/news/PENJELASAN-BADAN-POM-RI-Tentang-Kandungan-Bisfenol-A-BPA-dalam-Air-Minum-dalam-Kemasan-AMDK

[4] Lubis N, Soni D, Fuadi MDS (2021) Pengaruh suhu penyimpanan air minum pada botol kemasan polycarbonate (PC) yang beredar di daerah Garut terhadap kadar bisphenol-A (Bpa) Menggunakan Spektrofotometri Ultraviolet. J Chem 15: 223-230. https://doi.org/10.24843/JCHEM.2021.v15.i02.p14

[5] Baz L, Alharbi A, Al-Zahrani M, et al. (2023) The effect of different storage conditions on the levels of bisphenol A in bottled drinking Water in Jeddah City, Saudi Arabia. Adv Public Heal 2023: 1-6. https://doi.org/10.1155/2023/8278428

[6] Cooper JE, Kendig EL, Belcher SM (2011) Assessment of bisphenol A released from reusable plastic, aluminium and stainless steel water bottles. Chemosphere 85: 943-947. https://doi.org/10.1016/j.chemosphere.2011.06.060

[7] Manzoor MF, Tariq T, Fatima B, et al. (2022) An insight into bisphenol A, food exposure and its adverse effects on health: a review. Front Nutr 9: 1-16. https://doi.org/10.3389/fnut.2022.1047827

[8] Vandenberg LN, Chahoud I, Heindel JJ, et al. (2010) Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Environ Health Perspect 118: 1055-1070. https://doi.org/10.1289/ehp.0901716

[9] NIEHS. BPA (Bisfenol A). National Institute of Environmental Health Sciences, 2022. Available from: https://www-niehs-nih-gov.translate.goog/health/topics/agents/sya-bpa/

[10] Mufrodi Z, Suryani D, Rustiawan A, et al. (2019) Konsumsi air minum dalam kemasan (AMDK) pada mahasiswa consumption of bottled drinking water (AMDK) for university students. J Kesehat Masy 4: 55-63. https://doi.org/10.31943/afiasi.v4i2.55

[11] Widjaja A, Yohanes D, Kunto S (2014) Analisa persepsi konsumen tentang atribut produk AMDK. J Manaj Pemasar Petra 2: 1-8. https://publication.petra.ac.id/index.php/manajemen-pemasaran/article/view/1384

[12] Statistics Indonesia: Mayoritas rumah tangga Indonesia konsumsi air minum kemasan. Statistics Indonesia, 2023. Available from: https://databoks.katadata.co.id/datapublish/2023/10/27/

[13] Massahi T, Mirshafiee A, Parastouei K (2025) Bisphenol A migration and associated health risk in polyethylene terephthalate-bottled yogurt drinks (Doogh) under different storage scenarios. Sci Rep 15: 1-15. https://doi.org/10.1038/s41598-025-17347-w

[14] Honeycutt JA, Nguyen JQT, Kentner AC, et al. (2017) Effects of water bottle materials and filtration on bisphenol A content in laboratory animal drinking water. J Am Assoc Lab Anim Sci 56: 269-72. https://pmc.ncbi.nlm.nih.gov/articles/PMC5438920/

[15] Ighalo JO, Kurniawan SB, Khongthaw B, et al. (2024) Bisphenol A (BPA) toxicity assessment and insights into current remediation strategies. RSC Adv 14: 35128-62. https://doi.org/10.1039/d4ra05628k

[16] Dueñas-Moreno J, Mora A, Kumar M, et al. (2023) Worldwide risk assessment of phthalates and bisphenol A in humans: the need for updating guidelines. Environ Int 181: 1-13. https://doi.org/10.1016/j.envint.2023.108294

[17] National Toxicology Program: NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A. NIH Publ, 2015. Available from: http://ntp.niehs.nih.gov/about/%0Ahttps://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf

[18] Ramos RL, Moreira VR, Lebron YAR, et al. (2021) Phenolic compounds seasonal occurrence and risk assessment in surface and treated waters in Minas Gerais-Brazil. Environ Pollut 268: 1-11. https://doi.org/10.1016/j.envpol.2020.115782

[19] Chakraborty P, Shappell NW, Mukhopadhyay M, et al. (2021) Surveillance of plasticizers, bisphenol A, steroids and caffeine in surface water of River Ganga and Sundarban Wetland along the Bay of Bengal: Occurrence, sources, estrogenicity screening and ecotoxicological risk assessment. Water Res 190: 1-12. https://doi.org/10.1016/j.watres.2020.116668

[20] Cui FP, Yang P, Liu C, et al. (2021) Urinary bisphenol A and its alternatives among pregnant women: predictors and risk assessment. Sci Total Environ 784: 1-9. https://doi.org/10.1016/j.scitotenv.2021.147184

[21] Wang H, Liu Zhua, Tang Z, et al. (2020) Bisphenol analogues in Chinese bottled water: quantification and potential risk analysis. Sci Total Environ 713: 1-8. https://doi.org/10.1016/j.scitotenv.2020.136583

[22] Zhang H, Zhang Y, Li J, et al. (2019) Occurrence and exposure assessment of bisphenol analogues in source water and drinking water in China. Sci Total Environ 655: 607-13. https://doi.org/10.1016/j.scitotenv.2018.11.053

[23] Astuti RDP, Mallongi A, Choi K, et al. (2022) Health risks from multiroute exposure of potentially toxic elements in a coastal community: a probabilistic risk approach in Pangkep Regency, Indonesia. Geomatics, Nat Hazards Risk 13: 705-35. https://doi.org/10.1080/19475705.2022.2041110

[24] Mallongi A, Rauf AU, Daud A, et al. (2022) Health risk assessment of potentially toxic elements in Maros Karst Groundwater: a monte carlo simulation approach. Geomatics, Nat Hazards Risk 13: 338-63. https://doi.org/10.1080/19475705.2022.2027528

[25] United States Environmental Protection Agency: Bisphenol A. United States Environmental Protection Agency, 2017. Available from: https://downloads.regulations.gov/EPA-HQ-OPPT-2010-0812-0003/content.pdf

[26] Wang Z, Liu H, Liu S (2017) Low-dose bisphenol A exposure: a seemingly instigating carcinogenic effect on breast cancer. Adv Sci 4: 1-14. https://doi.org/10.1002/advs.201600248

[27] Santhi VA, Sakai N, Ahmad ED, et al. (2012) Occurance of bisphenol A in surface water, drinking water an plasma from Malaysia with exposure assessment from consumption of drinking water. Sci Total Environ 427-428: 332-8. https://www.sciencedirect.com/science/article/abs/pii/S0048969712005736

[28] Gusnawati G, Munira M, Rachmanto MR, et al. (2023) Analisis migrasi cemaran bisphenol-A (BPA) kemasan plastik polikarbonat (PC) pada produk air minum dalam kemasan galon di wilayah Kota Makassar. JambJChem 5: 46-52. https://doi.org/10.34312/jambchem.v5i1.19799%0A

[29] Hisa Faadhilah AT (2023) Review: pencemaran bisphenol A (BPA) dalam kemasan galon dan dampaknya bagi kesehatan. Farmaka 21: 223-9. https://doi.org/10.24198/farmaka.v21i2.46546

[30] Carwile JL, Luu HT, Bassett LS, et al. (2009) Polycarbonate bottle use and urinary bisphenol A concentrations. Environ Health Perspect 117: 1368-72. https://doi.org/10.1289/ehp.0900604

[31] Wisniewski P, Romano RM, Kizys MML, et al. (2015) Adult exposure to bisphenol A (BPA) in wistar rats reduces sperm quality with disruption of the hypothalamic-pituitary-testicular axis. Toxicology 329: 1-9. https://doi.org/10.1016/j.tox.2015.01.002

[32] Minguez-Alarcon L, Gaskins AJ, Chiu Y-H, et al. (2015) Urinary bisphenol A concentrations and in vitro fertilization outcomes among women from a fertility clinic. Hum Reprod 30: 2120-8. https://doi.org/10.1016/j.reprotox.2020.07.009

[33] Shen Y, Zheng Y, Jiang J, et al. (2015) Higher urinary bisphenol A concentration is associated with unexplained recurrent miscarriage risk: evidence from a case-control study in Eastern China. PLoS One 10: 1-9. https://doi.org/10.1371/journal.pone.0127886

[34] Ji M, Xia J, Di J, et al. (2019) Graphene-like boron nitride induced accelerated charge transfer for boosting the photocatalytic behavior of Bi₄O₅I₂ towards bisphenol a removal . RSC Adv 9: 4539-44. https://doi.org/10.1039/c8ra08984a

[35] Park JC, Lee MC, Yoon DS, et al. (2018) Effects of bisphenol A and its analogs bisphenol F and S on life parameters, antioxidant system, and response of defensome in the marine rotifer Brachionus Koreanus. Aquat Toxicol 199: 21-9. https://doi.org/10.1016/j.aquatox.2018.03.024

[36] Rees Clayton EM, Todd M, Dowd JB, et al. (2011) The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006. Environ Health Perspect 119: 390-6. https://doi.org/10.1289/ehp.1002883

[37] Regulation of the Minister of Industry Number 24/M-IND/PER/2/2010 concerning the Inclusion of Food Grade Logos and Recycling Codes on Plastic Food Packaging of 2010. Available from: https://peraturan.go.id/id/permenperin-no-24-m-ind-per-2-2010-tahun-2010

[38] Menteri Perindustrian Republik Indonesia. Peraturan Menteri Perindustrian Nomor 24/M-IND/PER/2/2010 Tahun 2010 tentang Pencantuman Logo Tara Pangan dan Kode Daur Ulang Pada Kemasan Pangan dari Plastik. 2010. Available from: https://peraturan.go.id/id/permenperin-no-24-m-ind-per-2-2010-tahun-2010