Carbon fiber reinforced polymers (CFRP) are recognized for their exceptional strength-to-weight ratio. They offer a viable and effective solution for strengthening and retrofitting masonry bridges, helping to extend their service life, improve structural performance, and meet modern safety and load requirements. Wrapping of CFRP around masonry elements can enhance their confinement and ductility. This flexibility plays a crucial role in preventing sudden brittle failure, allowing for controlled deformation, which is essential for blast resistance. Additionally, CFRP materials possess the ability to flex and absorb energy, which proves beneficial in containing and redistributing forces generated during an explosion, consequently reducing the risk of catastrophic failure. This study employed the coupled Eulerian–Lagrangian (CEL) technique available in the finite element software Abaqus/Explicit to simulate the blast loads. Various detonation scenarios were considered, taking into account factors such as location and their impacts on bridge structures. A detailed micro-model was developed using finite element software and accurate geometric data acquired from FARO laser scanning of the case study. The properties of masonry units and backfill were characterized using the Johnson-Holmquist II damage model and Mohr–Coulomb criteria. The Jones-Wilkins-Lee equation of state (EOS) was applied to replicate the behavior of trinitrotoluene (TNT). In accordance with the JH-II model, the researchers formulated a VUMAT code. The study examined the distinct damage mechanisms and overall structural responses of bridges. By evaluating the blast resistance of individual bridge models, the most critical scenarios were pinpointed. Carbon Fiber Reinforced Polymer (CFRP) was then utilized as a method to fortify bridges against blast loads. A comparison was made between the damage propagation before and after the reinforcement.