Acupoints as state-dependent neuroimmune gateways: insights from stress-responsive neuroimmune circuits

Hi-Joon Park

Acupuncture and Herbal Medicine ›› 2026, Vol. 6 ›› Issue (2) : 258 -260.

PDF (316KB)
Acupuncture and Herbal Medicine ›› 2026, Vol. 6 ›› Issue (2) :258 -260. DOI: 10.1097/HM9.0000000000000197
Commentary
research-article
Acupoints as state-dependent neuroimmune gateways: insights from stress-responsive neuroimmune circuits
Author information +
History +
PDF (316KB)

Abstract

Cite this article

Download citation ▾
Hi-Joon Park. Acupoints as state-dependent neuroimmune gateways: insights from stress-responsive neuroimmune circuits. Acupuncture and Herbal Medicine, 2026, 6 (2) : 258-260 DOI:10.1097/HM9.0000000000000197

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Pondeljak N, Lugović—Mihić L. Stress—induced interaction of skin immune cells, hormones, and neurotransmitters. Clin Ther 2020; 42(5): 757-770.

[2]

Tian J, Cao Y, Li Y, et al. A sympathetic—eosinophil axis orchestrates psychological stress to exacerbate skin inflammation. Science 2026; 391(6791): 1269-1277.

[3]

Chae Y, Kim HY, Lee HJ, et al. The alteration of pain sensitivity at disease—specific acupuncture points in premenstrual syndrome. J Physiol Sci 2007; 57(2): 115-119.

[4]

Ben H, Li L, Rong PJ, et al. Observation of pain—sensitive points along the meridians in patients with gastric ulcer or gastritis. Evid Based Complement Alternat Med 2012; 2012: 130802.

[5]

Rong P, Li S, Ben H, et al. Peripheral and spinal mechanisms of acupoint sensitization phenomenon. Evid Based Complement Alternat Med 2013; 2013: 742195.

[6]

Tan Y, Wang C, Yin X, et al. Understanding acupoint sensitization: a narrative review on phenomena, potential mechanism, and clinical application. Evid Based Complement Alternat Med 2019; 2019: 6064358.

[7]

Cui X, Liu K, Gao X, et al. Advancing the understanding of acupoint sensitization and plasticity through cutaneous C—nociceptors. Front Neurosci 2022; 16: 822436.

[8]

Cui X, Zhang Z, Xi H, et al. Sympathetic—sensory coupling as a potential mechanism for acupoints sensitization. J Pain Res 2023; 16: 2997-3004.

[9]

Lim DH, Ryu Y, Hahm DH, et al. Acupuncture points can be identified as cutaneous neurogenic inflammatory spots. Sci Rep 2017; 7(1): 15214.

[10]

Fan Y, Kim DH, Gwak YS, et al. The role of substance P in acupuncture signal transduction and effects. Brain Behav Immun 2021; 91: 683-694.

[11]

Yi YJ, Kim DH, Chang S, et al. Electroacupuncture at neurogenic spots in referred pain areas attenuates hepatic damages in bile duct—ligated rats. Int J Mol Sci 2021; 22(4): 1974.

[12]

Liu S, Wang Z, Su Y, et al. Somatotopic organization and intensity dependence in driving distinct NPY—expressing sympathetic pathways by electroacupuncture. Neuron 2020; 108(3): 436-450.e7.

[13]

Liu S, Wang ZF, Su YS, et al. A neuroanatomical basis for electroacupuncture to drive the vagal—adrenal axis. Nature 2021; 598(7882): 641-645.

[14]

Dong S, Zhao L, Liu J, et al. Neuroanatomical organization of electroacupuncture in modulating gastric function in mice and humans. Neuron 2025; 113(19): 3243-3259.e11.

[15]

Oh JY, Bae SJ, Ji JY, et al. Peripheral mast cell derives the effects of acupuncture in Parkinson’s disease. Front Aging Neurosci 2024; 16: 1376756.

[16]

Oh JY, Lee H, Jang SY, et al. Central role of hypothalamic circuits for acupuncture’s anti—Parkinsonian effects. Adv Sci (Weinh) 2024; 11(43): e2403245.

PDF (316KB)

0

Accesses

0

Citation

Detail

Sections
Recommended

/