The “Top 50 High Impact Researches of Traditional Medicine” published in 2021
Xiao Li, Dong Xu, Jianfeng Tu, Bo Pang, Xiaohui Yan, Yuanlu Cui, Yuefei Wang, Cunzhi Liu, Yi Wang, Junhua Zhang
The “Top 50 High Impact Researches of Traditional Medicine” published in 2021
In recent years, significant progress has been achieved in both basic and clinical research within the field of traditional medicine, garnering increasing attention worldwide. To further promote a high-quality and international development of traditional medicine, the editorial board of Acupuncture and Herbal Medicine provided a collection of the “Top 50 High-impact Researches of Traditional Medicine” published in 2021 through objective indicators and a strict selection process. The findings of the selected articles have a significant academic influence and possess considerable academic value both nationally and internationally. The selected articles cover a wide range of topics, including clinical research, acupuncture, pharmacology, chemistry, biosynthesis, medicinal plant resources, and new formulation and drug delivery system research on traditional medicine. Therefore, this article outlines the selection process of the top 50 high-impact research articles, analyzes their research characteristics, and provides a brief summary of their new findings and perspectives in the field of traditional medicine.
Academic influence / Ethnopharmacology / High-impact research / Traditional medicine
[[1]] |
Hu K, Guan WJ, Bi Y, et al.Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: a multicenter, prospective, randomized controlled trial. Phytomedicine. 2021;85:153242.
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Liu J, Li DD, Dong W, et al.Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial. Signal Transduct Target Ther. 2021;6(1):329.
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Qu L, Liang X, Tian G, et al.Efficacy and safety of mulberry twig alkaloids tablet for the treatment of type 2 diabetes: a multicenter, randomized, double-blind, double-dummy, and parallel controlled clinical trial. Diabetes Care. 2021;44(6):1324-1333.
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Siu PM, Yu AP, Chin EC, et al.Effects of tai chi or conventional exercise on central obesity in middle-aged and older adults: a three-group randomized controlled trial. Ann Intern Med. 2021;174(8):1050-1057.
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Mao JJ, Liou KT, Baser RE, et al.Effectiveness of electroacupuncture or auricular acupuncture vs usual care for chronic musculoskeletal pain among cancer survivors: the peace randomized clinical trial. JAMA Oncol. 2021;7(5):720-727.
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Tu JF, Yang JW, Shi GX, et al.Efficacy of intensive acupuncture versus sham acupuncture in knee osteoarthritis: a randomized controlled trial. Arthritis Rheumatol. 2021;73(3):448-458.
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Sun Y, Liu Y, Liu B, et al.Efficacy of acupuncture for chronic prostatitis/chronic pelvic pain syndrome: a randomized trial. Ann Intern Med. 2021;174(10):1357-1366.
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Mawla I, Ichesco E, Zöllner HJ, et al.Greater somatosensory afference with acupuncture increases primary somatosensory connectivity and alleviates fibromyalgia pain via insular γ-aminobutyric acid: a randomized neuroimaging trial. Arthritis Rheumatol. 2021;73(7):1318-1328.
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Zhang B, Hu Y, Shi X, et al.Integrative effects and vagal mechanisms of transcutaneous electrical acustimulation on gastroesophageal motility in patients with gastroesophageal reflux disease. Am J Gastroenterol. 2021;116(7):1495-1505.
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Liu S, Wang Z, Su Y, et al.A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis. Nature. 2021;598(7882):641-645.
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Zheng X, Lin W, Jiang Y, et al.Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB). Autophagy. 2021;17(11):3833-3847.
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Ma Y, Cui G, Chen T, et al.Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza. Nat Commun. 2021;12:685.
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Rai A, Hirakawa H, Nakabayashi R, et al.Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis. Nat Commun. 2021;12:405.
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Wang P, Li C, Li X, et al.Complete biosynthesis of the potential medicine icaritin by engineered Saccharomyces cerevisiae and Escherichia coli. Sci Bull (Beijing). 2021;66:1906-1916.
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Xiao Y, Shao K, Zhou J, et al.Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases. Nat Commun. 2021;12:2828.
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Niu Z, Zhu F, Fan Y, et al.The chromosome-level reference genome assembly for Dendrobium officinale and its utility of functional genomics research and molecular breeding study. Acta Pharm Sin B. 2021;11(7):2080-2092.
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Liu H, Wang X, Wang G, et al.The nearly complete genome of Ginkgo biloba illuminates gymnosperm evolution. Nat Plants. 2021;7(6):748-756.
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Liu Y, Wang B, Shu S, et al.Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12(1):3276.
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Li C, Olave M, Hou Y, et al.Genome sequences reveal global dispersal routes and suggest convergent genetic adaptations in seahorse evolution. Nat Commun. 2021;12(1):1094.
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Zhang Y, Shen Q, Leng L, et al.Incipient diploidization of the medicinal plant Perilla within 10,000 years. Nat Commun. 2021;12(1):5508.
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Wu Z, Liu H, Zhan W, et al.The chromosome-scale reference genome of safflower(Carthamus tinctorius) provides insights into linoleic acid and flavonoid biosynthesis. Plant Biotechnol J. 2021;19(9):1725-1742.
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Nair MS, Huang Y, Fidock DA, et al.Artemisia annua L extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants. J Ethnopharmacol. 2021;274:114016.
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Zhao L, Liu H, Wang Y, et al.Multimodal identification by transcriptomics and multiscale bioassays of active components in Xuanfeibaidu formula to suppress macrophage-mediated immune response. Engineering (Beijing). 2023;20:63-76.
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Zhao J, Tian S, Lu D, et al.Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qingfei Paidu decoction in the treatment of COVID-19. Phytomedicine. 2021;85:153315.
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Hong Y, Sheng L, Zhong J, et al.Desulfovibrio vulgaris, a potent acetic acid-producing bacterium, attenuates nonalcoholic fatty liver disease in mice. Gut Microbes. 2021;13(1):1-20.
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Guo B, Zhao C, Zhang C, et al.Elucidation of the anti-inflammatory mechanism of Er Miao san by integrative approach of network pharmacology and experimental verification. Pharmacol Res. 2022;175:106000.
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Liu J, Wang H, Yang F, et al.Multi-level fingerprinting and cardiomyocyte protection evaluation for comparing polysaccharides from six panax herbal medicines. Carbohydr Polym. 2022;277:118867.
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Wang Y, Tong Q, Ma SR, et al.Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota. Signal Transduct Target Ther. 2021;6:77.
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Kubatka P, Kello M, Kajo K, et al.Rhus coriaria L.(Sumac) demonstrates oncostatic activity in the therapeutic and preventive model of breast carcinoma. Int J Mol Sci. 2020;22:183.
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Huang Q, Su H, Qi B, et al.A SIRT1 activator, ginsenoside Rc, promotes energy metabolism in cardiomyocytes and neurons. J Am Chem Soc. 2021;143:1416-1427.
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Zeng H, Wang L, Zhang J, et al.Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of Nrf2 activity: therapeutic efficacy of dihydrotanshinone-I. Acta Pharm Sin B. 2021;11:71-88.
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Zhao MM, Lu J, Li S, et al.Berberine is an insulin secretagogue targeting the Kcnh6 potassium channel. Nat Commun. 2021;12:5616.
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Lan T, Yu Y, Zhang J, et al.Cordycepin ameliorates nonalcoholic steatohepatitis by activation of the AMP-activated protein kinase signaling pathway. Hepatology. 2021;74:686-703.
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Li X, Ge J, Li Y, et al.Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease. Acta Pharm Sin B. 2021;11:3527-3541.
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Liu H, Zhan X, Xu G, et al. Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases. Pharmacol Res.1053;164:105384.
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Zhang S, Wang Y, Yu M, et al.Discovery of herbacetin as a novel SGK1 inhibitor to alleviate myocardial hypertrophy. Adv Sci. 2022;9:e2101485.
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Ye J, Zeng B, Zhong M, et al.Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling. Acta Pharm Sin B. 2021;11:112-126.
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Zheng X, Li W, Xu H, et al.Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/MTOR and AMPK/MTOR pathway. Acta Pharm Sin B. 2021;11:3465-3480.
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Huang Y, Yu SH, Zhen WX, et al.Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2. Theranostics. 2021;11:6891-6904.
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Chang Z, Qin W, Zheng H, et al.Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates. Nat Commun. 2021;12:1253.
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Yu H, Chai X, Geng WC, et al.Facile and label-free fluorescence strategy for evaluating the influence of bioactive ingredients on FMO3 activity via supramolecular host-guest reporter pair. Biosens Bioelectron. 2021;192:113488.
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Fang S, Dong L, Liu L, et al.HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine. Nucleic Acids Res. 2021;49:D1197-D1206.
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Lan JS, Liu L, Zeng RF, et al.Tumor-specific carrier-free nanodrugs with GSH depletion and enhanced ROS generation for endogenous synergistic anti-tumor by a chemotherapy-photodynamic therapy. Chem Eng J. 2021;407:127212.
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Yu L, Wang Z, Mo Z, et al.Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy. Acta Pharm Sin B. 2021;11(7):2004-2015.
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Chi J, Sun L, Cai L, et al.Chinese herb microneedle patch for wound healing. Bioact Mater. 2021;6(10):3507-3514.
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Ou Q, Zhang S, Fu C, et al.More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing. J Nanobiotechnology. 2021;19(1):1-12.
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He Y, Zhao W, Dong Z, et al.A biodegradable antibacterial alginate/carboxymethyl chitosan/Kangfuxin sponges for promoting blood coagulation and full-thickness wound healing. Int J Biol Macromol. 2021;167:182-192.
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